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PCT - Post-Cycle-Therapie

Die Post-Cycle-Therapie ist eine Kombination von Medikamenten, die zur Verringerung der Nebenwirkungen von Steroiden eingesetzt werden. PCT ist ein Muss bei hohen Dosen, Langzeitzyklen oder Steroidkombinationen.

 

PCT-Effekte

  • Stellt den hormonellen Hintergrund wieder her
  • Erhält die gewonnene Muskelmasse
  • Verhindert Gynäkomastie
  • Verhindert die Atrophie der Hoden
  • Reduziert andere Nebenwirkungen

Hauptbestandteile der Post-Cycle-Therapie

OmatRomatase-Hemmer (Létrоzоlе, Аnаstrоzоlе usw.) - Sie werden während des Zyklus eingenommen, um östrogenbedingte Nebenwirkungen leicht aromatisierbarer Steroide (osterestosterоne, Sustаnone, МethannDrostenolon und so weiter).

Blocker des Östrogenrezeptors (Tamoxifen, Clomifen) - Sie werden nach dem Zyklus 2-3 Wochen lang eingenommen, um die natürliche Testosteronproduktion wiederherzustellen. Ihre Verwendung ist ein Kern von PCT, daher sollten Sie es nach dem Zyklus jeder Komplexität nehmen.

Chinesischer Gönner - Verhindert die Atrophie der Hoden. Normalerweise begleitet es schwere Zyklen, die länger als sechs Wochen dauern. Sie sollten in der 2-4. Woche eines Zyklus mit der Einnahme beginnen und fortfahren, bis Ihr Steroid vorbei ist, und dann mit der Einnahme von Östrogenrezeptorblockern beginnen.

Kabergolin (Déstinéx) ist eine Hemmung der Prolactinproduktion. Es begleitet die Zyklen mit Steroiden, die den Prolaktinspiegel erhöhen (Nāndrôlone, Тrénbоlone). Die übliche Dosierung beträgt 0,25 mg alle 4 Tage während Ihres Zyklus.

Itidditiоnаl cоmpоnеnts

Testen Sie einen Booster Stellen Sie die Hormonspiegel Ihres Körpers wieder her. Ihre Verwendung beginnt am Ende der Steroidaufnahme und dauert noch 2-3 Wochen (verringern Sie die Dosierung allmählich).

Hepato-schützende Substanzen - Verringerung der hepatotoxischen Wirkung einiger Steroide. Beginnen Sie mit der Einnahme in der 2. Woche eines Zyklus und fahren Sie drei weitere Wochen nach dem Ende eines Zyklus fort.

Оmеgа-3-Fettsäuren Normalisieren Sie den Chlesterolspiegel und verhindern Sie so Herz-Kreislauf-Probleme. Sie sollten sie während Ihres Zyklus und zwei weitere Wochen danach einnehmen.

Wachstumshormon und andere Peptide kann Ihnen helfen, die gewonnene Muskelmasse zu halten, auch Angstzustände, Depressionen und kardiovaskuläre Nebenwirkungen von Steroiden zu reduzieren.

Cortisоl blöken - Diese Medikamente unterdrücken den Katabolismus und helfen, die Muskeln vor Zerstörung zu bewahren. Nehmen Sie sie am Ende Ihres Zyklus und fahren Sie noch 3 Wochen fort. Es gibt jedoch keine hochwirksamen Medikamente in dieser Gruppe.

Beachten Sie, dass Prоviron nicht die optimale Substanz für PCT ist. Alle oben genannten Substanzen sind miteinander kompatibel.

Beispiele für die Post-Cycle-Therapie

Es gibt verschiedene PCT-Schemata, jedoch sind einige Merkmale gemeinsam. Beachten Sie, dass Östrogenblocker nur nach Beendigung der Steroidwirkung eingenommen werden. Die Dauer der PCT kann zwischen zwei und fünf Wochen variieren, was von der Hypophysenunterdrückung abhängt.

Clomifen (Tage - Dosierung).

3-150 / 12-100 / 15-50 / 15-25 - für einen sehr schweren Zyklus.

15-100 / 15-50 / 15-25 schwerer Zyklus.

30-50 / 15-25 - mittlerer Zyklus.

15-50 / 15-25 / 15-25 (alle zwei Tage) - Lichtzyklus.

15-50 / 15-25 – Оxаndrоlоnе, Méthāndrоstеnolone, Méthénólоne, StаnоzоlolТuranabol

Тоrеmifеne (Tage - tun)

3-120 / 12-60 / 15-30 / 15-15 - für einen sehr schweren Zyklus.

15-60 / 15-30 / 15-15 - schwerer Zyklus.

30-30 / 15-15 - mittlerer Zyklus.

15-30 / 15-15 / 15-15 (alle zwei Tage) - Lichtzyklus.

15-30 / 15-15 - andxandrolon, Мethandrostenolon, henethenolon, Stаnоzоlоl, оrāl Тurinabol.

Таmоxifen (Tagesdosis) - NEHMEN SIE ES NICHT NACH Nandrolon und Bolrenbolon Fahrräder!!!

3-80 / 12-40 / 15-20 / 15-10 - für ein sehr schweres Fahrrad.

15-40 / 15-20 / 15-10 - schwerer Zyklus.

30-20 / 15-10 - mittlerer Zyklus.

15-20 / 15-10 / 15-10 (alle zwei Tage) - leichtes Eis.

15-20 / 15-10 - andxandrolon, Мethandrostenolon, Мethenolon, Stаnоzоlоl, orales Тurinаbоl.

Andere Komponenten:

Cаbergolin (Dostinex) zur Verringerung des Proteinspiegels nach Nondrólóné- und Resinból-Zyklen (0,25 mg einmal alle vier Tage, während 1,5 Monaten).

Außerdem: Vitamin E - 200-400 IE pro Tag im 1. Monat der PCT, Zink - 50 mg / Tag.

PCT von Dr. Мiсhаеl Sсаlly

1-20 Tage: 10 HCG-Injektionen von 2000 IE, jeden zweiten Tag vor dem Schlafengehen.

1-30 Tage: Medium (Cliphencitrat), 50 mg, 2-mal täglich.

1-45 Tag: Nolvadex (Tamoxifencitrat), 20 mg, 2-mal täglich.

Dies ist das effizienteste Schema. Die Behandlung beginnt nach dem Ende eines Zyklus. Wenn Sie jedoch während Ihres Zyklus HCG eingenommen haben, ist die Verabreichung von HCG nicht erforderlich, da die Funktion der Hoden normal sein sollte.

Alternative Version von PCT

Die P ost Cycle-Therapie beginnt, wenn die Wirkung des Steroids abgeschlossen ist. Daher müssen Sie auf seine Halbwertszeit achten.

Leichte PCT (1 oder 2 Medikamente).

Amoxifen 20 Tage - 20 mg + 15 Tage - 10 mg

IfLomifen 20 Tage - 50 mg + 15 Tage - 25 mg

Starke PCT (1 oder 2 Medikamente).

Amoxifen 20 Tage - 30 mg + 15 Tage - 20 mg + 10 Tage - 10 mg

IfLomifen 20 Tage - 100 mg + 15 Tage - 50 mg + 10 Tage - 25 mg

Sehr starkes PCT (alle Medikamente).

Oxamoxifen - 20 Tage - 30 mg.

OmLomifen - 20 Tage - 100 mg. + 15 Tage - 50 mg + 10 Tage - 25 mg.

Hinweis: Verwenden Sie kein oxamoxifen, wenn Ihr Zyklus Prolaktin-induzierende Substanzen enthält.

Beispiel eines Zyklus mit PCT

Beachten Sie, dass Aromatasehemmer nicht nur Gynäkomastie verhindern, sondern auch die Testosteronkonzentration erhöhen. Dies geschieht aufgrund der Blockierung der Testosteronumwandlung in Östrogen.

Gonadotropin bewahrt die Empfindlichkeit der Hoden gegenüber endogenen gonadotropen Hormonen, was eine viel schnellere Erholung nach dem Zyklus ermöglicht.

Tamoxifen ist ein Schlüsselelement der Post-Zyklus-Therapie. Es initiiert die Sekretion von endogenem Testosteron, indem es die Östrogenrezeptoren in der Hypophyse blockiert, jedoch sind mlоmiphéné und Тorémifen besser bevorzugt.

Wachstumshormon und Peptide sind gut für die Unterdrückung von Katabolismus.

Beispiel eines Progestin-Zyklus

Einige Steroide wie Deca, bolrenbolon können den Prolaktinspiegel erhöhen, was zu einer verminderten Libido, Wasserretention und Prolaktin-induzierter Gynäkomastie führt. Cabergolin kann diese Nebenwirkungen vollständig verhindern.

Sie können Clomid anstelle von Tamoxifen oder einem sichereren Medikament - Toremifen - verwenden.

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Anastrozol Bodybuilding

Anastrozole is an aromatase inhibitor. In simple terms, it blocks functioning of aromatase enzyme, which is responsible for converting testosterone to estradiol. The drug is used during cycle with aromatizable anabolic steroids to reduce the negative effects of estrogen on the body.

Initially we should discuss the positive and negative effects of estrogen on the male body. Estrogens play an important role in various functions of the male and female body. The general health of the athlete and his results depend on these very functions.

Positive Effects of Estrogens:

  • play an important role in the immune system;
  • necessary in the nutrition of bone tissue;
  • have a positive effect on cholesterol levels;
  • necessary for the production of growth hormone (GH) and insulin-like growth factor (IGF);
  • play an important role in maintaining the “fluid balance” in the body at the proper level;
  • help to absorb glucose;
  • support sex drive.

Negative aspects of increased estrogen levels:

  • retain fluid in the body, swelling;
  • fatigue and increased muscle blockage during training;
  • acne that has not been previously observed;
  • the risk of prostate cancer increases;
  • blood clotting increases;
  • the risk of cardiovascular disease increases;
  • the risk of hypertension (high blood pressure) increases;
  • the risk of stroke increases;
  • cause gynecomastia (swelling and itching in the nipple area, breast enlargement);
  • decreased sexual desire;
  • female obesity;
  • extra sweating;
  • possible sleep disturbances;
  • can provoke hair loss;
  • possible disturbances in the work of the gastrointestinal tract.

 

With the help of aromatase inhibitors, the level of estrogens is controlled. The competent use of anastrozole allows not only to counteract aromatization, but also to simultaneously increase the level of free testosterone. If you follow the dosage regimen, the agent will be perfectly tolerated by the body, without any negative effects.

The drug Anastrozole was invented at the end of the last century, its original purpose – the treatment of breast cancer. The effectiveness of the drug in this area has been proven, this contributed to its popularity in sports when using anabolic steroids by athletes.

Anastrozole in bodybuilding is used when the athlete begins to use anabolic steroids, which prone to aromatization, such as testosterone and danabol. This steroids may cause gynecomastia. In simple terms, this is the growth of the mammary gland. That is why many athletes take anastrozole during steroid cycles.

It suppresses the enzyme, interfering with the destruction of testosterone and the production of estrogen. The main effect of anastrozole is:

  • prevention of fluid retention;
  • suppression of the production of female hormones;
  • stimulation of natural testosterone production;
  • prevention of testicular atrophy;
  • increased libido in men;
  • prevention of gynecomastia;
  • improving muscle tone;
  • an increase in the level of anabolic hormones in the blood;
  • prevention of hypertension.

To avoid serious side effects on the testosterone and danabol cycle, anastrozole should be used immediately. It is easier to prevent the development of serious diseases than to cure them.

Possible side effects of anastrozole

Any medicine has both positive effect and negative one. Problems can arise if the athlete exceeds the recommended dose or takes the drug for too long. For the normal functioning of the male body, estrogens are necessary. If you take anastrozole for a long time and uncontrollably on the cycle of anabolic steroids, the level of this hormone can reach critically low levels.

This can cause a number of side effects:

  • memory impairment,
  • apathy, drowsiness,
  • fatigue;
  • frequent mood swings up to depression;
  • violation of oxygen metabolism in tissues;
  • deterioration of blood clotting;
  • violation of the functionality of nerve cells;
  •  joint pain;
  • decreased bone strength (osteoporosis);
  • headache, dizziness;
  • decreased libido;
  • low sperm motility;
  • increase in blood cholesterol levels;
  • anemia, thromboembolism, thrombophlebitis;
  • skin rashes and itching;
  • thinning hair, baldness;
  • lack of appetite while gaining weight;
  • liver disease.

All this suggests that anastrozole in bodybuilding should be used with caution, blood counts should be monitored, and the recommendations of professionals should be followed.

How to use anastrozole on the cycle of anabolic steroids?

If you don’t use aromatizable steroids, then you probably won’t need the drug. And if you do steroid cycle with testosterone, then you cannot do without anastrozole.

It can be used even before the cycle of anabolic steroids in case your level of aromatization is increased, as can be seen from the analyzes. You do not need to take this drug at random. Anastrozole is also used during PCT to reduce the level of aromatization, if this occurs and is monitored by tests for Estradiol.

Anastrozole can be taken at any time of the day, but the maximum effect can be achieved when taken on an empty stomach. If you drink a medicine with plenty of water, it will be absorbed faster and penetrate into the bloodstream. When using testosterone, anastrozole is taken both on different days and every day, it all depends on your level of aromatization, which proceeds differently for everyone due to individual characteristics, as well as depending on the dosage of testosterone and its ester.

You should take Anastrozole during the whole period of steroid action. For example, when using testosterone propionate, anastrozole must be taken up to the fifth day after the last injection. And after long estered testosterones (enanthate, decanoate, cypionate, sustanon, etc.), anastrozole has to be taken for the third week after the last injection, and sometimes longer.

If you take steroids with a short half-life (methandrostenolone), then start taking anastrozole with a lower dosage and frequency (0.5 mg three times a week or every other day). After 15-20 days of administration, the blood test should be repeated.

When using testosterone propionate, for example, 100 mg. / every other day, the dosage of anastrozole can be 0.5 mg every other day, or every day 0.5 mg, or 1 mg every day, and the last intake of anastrozole should be on the fifth day after the last injections.

If you are using long-ester steroids, then start taking anastrozole few days after the first injection, and after two to three weeks check with the aim of adjusting the dosage, and the subsequent recheck should be done at least once a month.

It is important to carefully monitor your body in order to timely determine the imbalances in the hormonal background and timely prevent the occurrence of side effects, changing the frequency of taking accompanying drugs, up to their cancellation.

 

During post-cycle therapy, anastrozole is not used if the level of aromatization is not rises above the permissible values. It is not permissible to replace anastrozole with tamoxifen, since they have mutually exclusive effect.

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Bodybuilder Insulin

Insulin in bodybuilding

Why is insulin needed and how does it work?

Insulin is a peptide hormone, formed in the beta cells of the islets of Langerhans of the pancreas. It has a multifaceted effect on metabolism in almost all tissues. The main action of insulin is to lower the concentration of glucose in the blood. In bodybuilding, insulin is used due to its pronounced anabolic effect.

Insulin increases the permeability of plasma membranes for glucose, activates key glycolysis enzymes, stimulates the formation of glycogen from glucose in the liver and muscles, and enhances the synthesis of fats and proteins. In addition, insulin inhibits the activity of enzymes that break down glycogen and fats. That is, in addition to the anabolic effect, insulin also has an anti-catabolic effect.

The transport of glucose in two types of tissues depends to the greatest extent on insulin: muscle tissue and adipose tissue – this is the so-called. insulin-dependent tissues.

Insulin effects

  • increased absorption of glucose and other substances by cells;
  • activation of key glycolysis enzymes;
  • an increase in the intensity of glycogen synthesis – insulin accelerates the storage of glucose by liver and muscle cells by polymerizing it into glycogen;
  • a decrease in the intensity of gluconeogenesis – the formation of glucose in the liver from various substances of a non-carbohydrate nature (proteins and fats) decreases.

Anabolic action of insulin

  • enhances the absorption of amino acids by cells (especially leucine and valine);
  • enhances the transport of potassium ions into the cell, as well as magnesium and phosphate;
  • enhances DNA replication and protein biosynthesis;
  • enhances the synthesis of fatty acids and their subsequent esterification – in adipose tissue and in the liver, insulin promotes the conversion of glucose into triglycerides; with a lack of insulin, the opposite occurs – the mobilization of fats.

Insulin anti-catabolic action

  • inhibits protein hydrolysis – reduces protein degradation;
  • reduces lipolysis – reduces the flow of fatty acids into the blood.

The Dangers of Using Insulin

Perhaps the main factor in insulin’s bad reputation is the risk of hypoglycemia. On any forum, you can find messages of a warning nature, as if even a slight excess of the dose of insulin could be fatal. However, scientific and practical evidence suggests otherwise: the lowest lethal dose of insulin is 100 U, that is, a full insulin syringe. Many people survive even after 3000 IU doses! But in the event of a serious insulin overdose, there is no time to call an ambulance in a clear consciousness. Depending on the degree of overdose, it takes from several minutes to several hours to the development of a coma, so even lethal doses of insulin do not cause death if the timely flow of glucose into the blood begins.

What insulin is used in bodybuilding

In bodybuilding, short-acting and ultra-short-acting insulin should be used:

Short-acting insulin

Short insulin begins to act when injected subcutaneously after 30 minutes (therefore, it is administered 30-40 minutes before meals), the peak of action occurs after 2 hours, disappears from the body after 5-6 hours.

The best choice:

  • Humulin Regular
  • Actrapid HM

Ultra-short-acting insulin

Ultra-short insulin begins to act in 0-15 minutes, peak in 2 hours, disappear from the body in 3-4 hours. It is more physiological and can be administered immediately before a meal (5-10 minutes) or immediately after a meal.

The best choice:

  • Insulin aspart (NovoRapid Penfill, NovoRapid FlexPen).
  • Insulin lispro (Humalog)
  • Insulin glulisine (Apidra) are all semi-synthetic analogs of human insulin.

Advantages and Disadvantages of Insulin

Benefits:

  • Low cost of the cycle
  • Availability – the drug can be purchased freely at the pharmacy
  • High quality – counterfeits are practically excluded, unlike steroids
  • Lack of toxicity, low frequency of side effects, almost complete absence of the consequences of the course
  • Pronounced anabolic effect
  • Can be combined with anabolic steroids and other drugs
  • Lack of androgenic effects
  • Insulin DOES NOT have a toxic effect on the liver or kidneys, and also DOES NOT CAUSE sexual dysfunction.

Disadvantages:

  • Complex reception scheme
  • Significant fat gain
  • Hypoglycemia

Nebenwirkungen

Hypoglycemia or a decrease in the concentration of glucose in the blood, which entails all other manifestations. Hypoglycemia can be easily prevented, read about it in the main article – Hypoglycemia.

Itching in the area of ​​the injection

Allergy – extremely rare

Decreased endogenous insulin secretion – occurs only with very long courses with high doses of insulin

A decrease in endogenous insulin secretion occurs only during exogenous use of insulin (duration of action of short-acting or ultra-short-acting insulin). Insulin, unlike other endocrine hormones, is not regulated by the hypothalamic-pituitary system and does not have a feedback principle. The only stimulators of insulin synthesis are the level of glycemia and food intake (through the mechanism of the secretin cascade). Therefore, even a very long-term use of insulin does not change its secretion, after its withdrawal. But this is not a positive quality of the use of this hormone, since the risk of developing hypoglycemic conditions is very high !! To stop hypoglycemia, it is necessary to use fast carbohydrates, and since short or ultrashort insulin is used, all fast carbohydrates entering the bloodstream are carried away in the process of lipogenesis in adipose tissue. Excessive use of insulin, its “overdose” leads to an increase in fat reserves. As an anabolic hormone, it is weak, but hypoglycemia leads to the release of growth hormone, which has an anabolic effect.

 

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Clomid und Nolvadex für pct

clomid nolvadex pct

Tamoxifen (Nolvadex) and Clomid for PCT

In this article we will try to figure out the difference between Tamoxifen and Clomid, as well as which one is better and more effective for PCT. There is a lot of disagreement on this topic and it often happens that opinions differ greatly. The correctness of the choice always ensures an effective recovery period after the cycle, and this is the most important thing on the PCT.

 

Clomiphene citrate, also known as Clomid, as well as Tamoxifen previously known as Nolvadex, belong to antiestrogenic drugs. They are almost identical in structure, and belong to the group of specific estrogen receptors modulators. Their effect is focused on blocking the hormone estrogen by intimate association with receptors. For men, both remedies prevent the feedback of estrogen hormones on the hypothalamus and cause the production of gonadoliberin. For some reason, almost all bodybuilders are sure that only Clomid is able to stimulate natural testosterone. But practice has shown that Tamoxifen does an excellent job with this task.

In the late 70s, serious research was carried out at the University of Ghent, located in Belgium, which confirmed the advantages of Nolvadex over Clomid – in terms of increasing the amount of its own hormone testosterone in the body. Scientists were interested in the result of taking drugs when they influence the functioning of the endocrine system. It was found that if you take Nolvadex for 10 days with a daily dosage of 20 mg, you can actually increase the presence of testosterone inside the serum by as much as 142%. For comparison, Clomid in this variant would need to be taken at 150 mg daily. If we consider the price of both drugs, then we will understand how profitable it is to take Nolvadex.

 

The difference of Clomid (clomiphene) and nolvadex (tamoxifen)

Clomid tends to affect estrogen receptors directly in the pituitary gland and ovaries. The drug has no effect on the amount of estrogen in the blood.

Nolvadex or Tamoxifen blocks all types of receptors. Experts call Clomid a selective blocker, while Nolvadex is indiscriminate one. In simple words, Nolvadex tends to bind to estrogen receptors located throughout the athlete’s body. Clomid effectively fights the inhibitory effect of estrogens on the normal functioning of the pituitary gland and hypothalamus. Nolvadex also allows you to restore natural testosterone in the shortest possible time.

It should be said about the disadvantages of Tamoxifen. It is quite toxic and can cause lack of appetite during the cycle, unpleasant nausea, and increases the risk of thrombosis. Since this modern drug increases the number of progesterone receptors, it is not recommended to use it along with progestogenic steroids, like Anapolone, various forms of Trenbolone and Nandrolones.

 

Fazit

 

Why might Tamoxifen be a better choice than Clomid? There are a number of reasons for this, which we will provide below.

 

Tamoxifen can restore the required amount of the testosterone hormone in the athlete’s body, with  less critical effects on the pituitary gland than Clomid.

Tamoxifen reduces the amount of bad cholesterol, which is important for all athletes taking steroids.

Clomid has the ability to increase globulin levels, which is directly related to testosterone. This is bad for an athlete’s weight gain.

In terms of pricing, the cost advantage is again on the side of Tamoxifen, since Clomid is more expensive drug.

Common disadvantages

Both drugs have some drawbacks. When taken, they inhibit the normal functioning of the testicles, suppress the production of insulin-like growth factor, increase the level of globulin in the body (which bind sex hormones), and increases the concentration of estrogens by several times. And one more important point – you cannot take both drugs for too long

How and When to Take Nolvadex (Tamoxifen)

During a cycle of strong anabolic steroids, it is strongly recommended to use aromatase inhibitors. The most famous of them is probably Proviron, known to many athletes. It causes a slight increase of testosterone in the blood due to the inhibition of the undesirable of aromatization. Also it does not have a negative effect on the production of growth hormone.

At the final week and 2 more weeks after the cycle, it is necessary to take Tamoxifen as the main component of the PCT. If aromatase inhibitors are not used, one should start taking Nolvadex on the 2nd week of the cycle, and continue up to 2 – 3 weeks after the end of the cycle. In this case, 10 to 20 mg of the drug should be used daily.

There is no need to take aromatase inhibitors if non-aromatizable steroids are used. It is wise to introduce Tamoxifen exclusively at the end of the cycle.