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Finasteride for bodybuilding

In this article we’ll discuss the role of finasteride in bodybuilding

Our body produces an enzyme called 5 – alpha – reductase. This enzyme converts Testosterone into the most powerful physiological androgen, Dihydrotestosterone. When this enzyme in normal quantities, then everything is fine, but when too much 5-alpha-reductase is produced, then steroid user begins to face such “unpleasant little things” as: baldness, increased hair growth, oily skin , excessive sweating (which smells like a real goat), acne, hyper-expressed libido and the most unpleasant thing – prostatic hypertrophy.

Finasteride is a specific, competitive inhibitor of 5 – alpha – reductase. When entering the blood plasma, it extremely quickly binds to this enzyme in the same way as Testosterone does, only in this case the conversion to DHT no longer occurs.

Actually, in the human body there are 2 types of 5 – alpha – reductase. The first is located mainly in the skin of the body and is dominant in the part of the head where hair grows. The second type is found in the tissues of the genital organs, the prostate.

So, Finasteride primarily has an affinity with the type 5 – alpha – reductase, which predominates in the genitals and the prostate gland. As for the type due to which AAS users are actively bald, then Proscar also interacts with him, but to a lesser extent.

Nevertheless, the competent use of Finasteride is really the only salvation for those whose conversion to Dihydrotestosterone exceeds reasonable limits. Therefore, this substance will at least partially stop losing hair on your head and slow down the growth of the prostate.

But first of all, you need to understand in the case of taking which specific AAS , it generally makes sense to take Finasteride. And there are actually quite a few of them, but they (with the exception of two) are the sales leaders:

  • Testosteron
  • Methandrostenolone
  • Nandrolon
  • Methyltestosterone
  • Fluoxymesterone (Halotest)

As everyone knows, if specifically, you weren’t happy to be born a pure mesomorph, then in relation to Bodybuilding and Powerlifting, any cycle without Testosterone is the road to nowhere (except perhaps the last 14-10 days of drying, when you decided to achieve direct peak dryness and muscle hardness).

With regards to Methandrostenolone, then you can do without it absolutely calmly, but for some reason most do not want to do without it. Nandrolone turns into Dihydronandrolone – a substance that is completely inert in activity both in muscles and in peripheral tissues (the same scalp and prostate), but then Dihydronandrolone can lead to a sharp disruption of neuro-muscular conduction, which on the one hand means a lack of growth muscles and strength (strength can finally fall), and on the other hand, it can provoke problems with erection. So here Finasteride is in the subject.

Methyltestosterone and Fluoxymesterone are the very exceptions discussed above. In general, it is completely pointless to suppress their androgenic side, because thanks to it they have the main effects, moreover, without conversion to DHT, they have strong androgenic activity. So there is only one piece of advice – to avoid.

The list of steroids that do not turn into DHT at all, or the degree of their conversion is scanty so much that it can be safely neglected. They do not possess noticeable androgenic activity by themselves:

  • Methenolone (Primobolan),
  • Boldenone,
  • Oxandrolone,
  • Oral Turinabol.

And finally, there is a list of steroids against which Finasteride is powerless and useless:

  • Trenbolone,
  • Oxymetholone,
  • Stanozolol,
  • Drostanolone,
  • Mesterolone (Proviron).

This article does not indicate specific schemes and doses for Finasteride, because firstly the article is not about this, and secondly, the plan should be selected individually for the person based on the results of blood tests and dosages of the AAS themselves.

Important:

Due to the ability of type II 5-alpha reductase inhibitors to suppress the conversion of testosterone to dihydrotestosterone, finasteride preparations can cause abnormalities in the development of the external genital organs in a male fetus if they are prescribed to pregnant women.

Women going to become pregnant or are pregnant should avoid contact with crushed or disintegrated finasteride tablets due to the potential for finasteride to enter the body and the subsequent potential risk to the male fetus. A small amount of finasteride has been detected in semen. In this regard, women who can potentially become pregnant or are pregnant should avoid contact with the sperm of patients taking finasteride.

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Fat burners in sports

Fat burners are very popular in modern world. In this article we’ll talk about different types of fat burners and how they work.

Fighting excess weight is an actual problem for many people and every second visitor of the gym has the motivation “I want to lose weight”.

Sports fat burners for women and men

Strictly speaking, the name “fat burner” is incorrect. None of the approved drugs directly breaks down fat deposits.

The process of breaking down fats – lipolysis – is quite complex, and we will not describe it in detail. In short, excess body fat is processed by the body in conditions of a lack of energy from food. That is, a calorie deficit.

This means that in order to lose weight, you must spend more energy than you receive or eat less calories than you spend. From these two principles, in general, you can see how sports fat burners work – either increase energy expenditure, or block hunger or the absorption of nutrients.

Types of sports fat burners:

thermogenics

appetite suppressants

calorie blockers (fats or carbohydrates)

lipotropics

Thermogenics

Thermogenics are substances that increase body temperature, thereby increasing calorie expenditure. If you decide to purchase the occasional sports fat burner, there are likely to have nervous system stimulants such as caffeine, yohimbine, and synephrine.

Koffein is perhaps the most familiar CNS stimulant: it is found in coffee, cocoa, tea, Coca-Cola, mate, guarana. It stimulates the release of adrenaline, which means an increase in blood pressure and body temperature. Caffeine increases endurance, allows you to concentrate on the training process and the desired result.

Yohimbine is considered the “light version” of caffeine. In terms of the mechanisms of influence on the human body, it is similar to caffeine, but initially it was used as an aphrodisiac and a remedy for erectile dysfunction. In addition, it has a mild antidepressant effect, that is, improves mood.

Synephrine is isolated from bitter oranges – oranges. But it is also found in other types of citrus fruits. Sports nutrition manufacturers present synephrine as a safe and non-toxic alternative to ephedrine, a CNS stimulant banned in most countries.

Since the mechanism of all thermogenics is approximately the same, then the side effects from them are similar. These are tachycardia, increased blood pressure, sweating, heartburn and other digestive problems, excessive agitation and anxiety. Thermogenics should not be taken in the afternoon to avoid insomnia.

In addition, tolerance develops to stimulants of the nervous system over time, it is necessary to increase the dosage, which may cause side effects. Together with physical activity, it is simply harmful to the body, especially to the heart. And with an increase in tolerance the fat burning effect decreases.

Appetite suppressants

Appetite suppressants – anorectics – act on the hunger and satiety center, allowing you to feel full from less food. Therefore you do not suffer from hunger in between meals. The most effective drug is Sibutramine, which is used to treat obesity. At one time, fluoxetine was used to suppress appetite by athletes, which, strictly speaking, belongs to antidepressants.

But both of them are prescription drugs in many countries. Other anorectics, similar in action to amphetamine, like itself, are prohibited from circulation.

It is also worth mentioning here that the line between tegmogenics and appetite suppressants is rather blurred – the center of hunger is strongly associated with serotonin and adrenaline. So, caffeine also suppresses appetite to some extent, and fluoxetine has a mild stimulating effect. This means that the side effects of anorectics will be similar to the side effects of CNS stimulants – high blood pressure, excessive nervous excitement, anxiety and insomnia, tremors and tachycardia. The danger and harm of these fat burners also lies in the fact that often people who take these drugs for a long period of time without a doctor’s supervision, eating behavior is disturbed, which leads to serious gastrointestinal diseases, insomnia and general anxiety.

Thus, appetite suppressants are not really sports fat burners for weight loss, but rather medical ones. They are used to treat obesity and strictly under the supervision of a physician.

Calorie blockers

Calorie blockers interfere with the absorption of fats and carbohydrates in the digestive tract, respectively. The enzymes lipase and amylase lose the ability to break down food and are simply removed from the body. The most popular drugs are Xenical and Metformin.

They are effective for weight loss, however they may cause stomach upset. In addition, the intake of nutrient blockers leads to a state of hunger, which interferes with an effective training process.

These drugs are taken with virtually harmless medical supervision to minimize the harm from this type of fat burner.

Fat burners effective under stress
Lipotropics are substances that stimulate the processes of fat breakdown at the cellular level. They facilitate the release of fats from deposits and transport them to the site of breakdown during exercise.

Lipotropics

Omega-3, although its fat burning effect is not the most popular among athletes. For weight loss, its ability to regulate metabolism and reduce insulin sensitivity is important.
Linoleic acid is another fatty acid involved in energy metabolism and the breakdown of body fat. Although its effectiveness is often questioned, linoleic acid can often be found in fat burning complexes.

Choline or Vitamin B4. Participates in the synthesis of acetylcholine – a neurotransmitter, ensures the functioning of the nervous system, the permeability of neurons and the required speed of nerve impulses, which is important for intense sports.

Betaine is a vitamin-like substance derived from choline. Promotes the breakdown of fats, and also increases muscle endurance. Reduces the risk of sharp pain in the liver, which appear during cardio training.

Melatonin is a sleep-regulating hormone. Its effect on weight loss is indirect, the main effect of melatonin is to normalize the rhythms of the body. Meanwhile, trainers and sports nutritionists agree that both healthy sleep and the stability of sleep and wakefulness are important for losing weight, so you should try the “sleep hormone”.

L-carnitine is perhaps the most effective sports fat burner. It accelerates the transport of fatty acids to the site of their breakdown during exercise. In addition, it has a pronounced anabolic effect, which has a beneficial effect on muscle mass. It also improves endurance and stress tolerance. L-carnitine is considered a sports fat burner for girls, as it is effective in such “typically female” sports as dancing, running and aerobics.

All lipotropics are safe fat burners, since side effects appear when the dosage is significantly exceeded. When used normally, they cause blood pressure and heart problems, fever, irritation and insomnia. Most of them have a positive effect on other human organs and systems.

The disadvantage of lipotropics is that they are effective only in combination with sports. That is, it will not work if you do nothing.

Other Slimming Drugs

Diuretics can be considered as slimming products, however, the weight loss occurs at the expense of water. And their danger is in dehydration of the body and high load on the kidneys. So these are not fat burners at all.

So what’s the best sports fat burner?

If we talk about the effectiveness and minimization of harm from side effects, then we would recommend the fat burner L-Carnitine. It not only helps you lose weight, but it also strengthens your joints, improves the functioning of the nervous system, and generally invigorates you for training. As a sports fat burner and general health supplement, L-Carnitine is equally suitable for women and men.

We would also like to remind you that for effective weight loss, it is worth paying great attention to a balanced diet and physical activity: a combination of aerobic training and strength training. A high-quality and durable result can be achieved by combined approach.

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Thymosin (TB 500) – a wonder drug for wound healing

You can buy TB-500 (Thymosin) here

TB-500 (Thymosin) is a synthetic version of a naturally occurring peptide hormone found in all types of cells. The usage of TB-500  accelerates wound healing, and exhibits a multidirectional protective effect. Recent studies have shown that Thymosin has some effect on athletic performance. For the first time Thymosin was found in thymus.

In medical practice TB-500 accelerates wound healing, and is used for restoration of myocardium after infarction, and for treatment of different types of ischemia.

As a doping it was initially used for racing horses and later on for athletes of different kind of sports. For long time it was considered undetectable in doping tests, however nowadays it is detectable by liquid chromatography.

Effects

Thymosin speeds up recovery of all types of  muscles (including heart), ligaments, joints and skin. Actually it has beneficial effect on all the tissues.

Reduces inflammation

Promotes the formation of new blood vessels in all tissues, which improves their nutrition.

Has protective effect on nervous system.

Increases production of luteinizing hormone, and testosterone accordingly.

Increases the sensitivity of tissues for insulin, which is beneficial in case of diabetes.

Improves joint mobility and elasticity of ligament

Regenerates heart muscle and reduces the risk of heart attack

Unlike popular misconception TB-500 has no significant effect on muscle growth and strength.

Thymosin Cycle

Thymosin Beta 4 cannot be taken orally, since stomach acid easily destroy it, therefore it should be injected into the muscle or under the skin. Its major application is for treatment of injuries, and as cardioprotector.

Loading phase: dose 2-6 mg a week, split into two injections (2-3 mg each: Monday, Thursday). The length of the loading phase is 4 weeks.

Supporting phase: 2-4 mg a week, split into 2 injections. Duration 4-8 weeks.

Alternative scheme: 10 mg for the 1st week (1-2 mg daily), then 5 mg a week (optimally split into two injections) for 5 weeks and a maintenance dose of 10 mg per month (2 mg every 6 days ) is optimal and effective in the opinion of many US athletes using the TB500. In total, we get 18 vials of 2 mg for the first 6 weeks + 5 vials of 2 mg for 4 weeks to maintain the results.

 

Preparation and storage of the solution

 

Cool the bottle to room temperature and introduce the required volume of water for injection (which should flow down the wall of the bottle), then stir with rotating movements (do not shake), or put it in the refrigerator for a while. It is better to use saline solution, which allows it to be frozen.

In the refrigerator, the solution remains stable for about 8 days, in the frozen state – up to a month.

Nebenwirkungen

According to different studies there are no toxic or serious side effects even at a dose of 1260 mg.

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Testicular atrophy, prevention and treatment

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Testicular atrophy, is a condition in which the male testes shrink significantly. In case of testicular atrophy, the function of testes almost completely disappears, that is, the production of testosterone and sperm is sharply reduced. The resulting conditions are called “Androgenic deficiency” and “Male infertility”, respectively. Testicular atrophy is irreversible. The volume of an atrophied testicle is usually 6 cubic centimeters or less. The average volume of a healthy, undamaged testicle in men is 17-18 cubic centimeters. There are reversible states of damaged testicles – hypotrophy with partial loss of function.

Taking steroid hormones can stop the natural testosterone production. This happens due to the reverse mechanism, when the hypothalamus recognizes over-abundancy of sex hormones (including androgens, progestins and estrogens) and stops producing of gonadotropic hormone. It normally stimulates Leydig cells in the testes to produce testosterone. The lack of gonadotropic hormone causes testes stop functioning and shrink.

HPTA hypothalamus-pituitary-testes axis: The hypothalamus produces gonadotropic hormone, which promotes testosterone production in the testes. Testosterone, in turn, suppresses the activity of the hypothalamus and the pituitary gland to some extent.

Signs of testicular atrophy / hypotrophy

Decreased testosterone production, which is accompanied by worsening of general well-being, decreased performance, mood, desire and willingness to exercise, decreased libido, impaired potency, muscle loss, feminization and other signs of testosterone deficiency.

Decrease in semen volume, sperm quantity and quality.

Leydig cells make up only about 5% of the testicle mass. Therefore, palpation analysis of testicular size is not a reliable method for assessing the loss of Leydig cells, since the volume can change very slightly (only 5%) with almost complete suppression of function. The loss of spermatogenesis cells is more noticeable on examination and palpation; from the loss of these cells, the volume of the testicles is significantly reduced.

Treatment and prevention of Testicular atrophy

Testicular atrophy can develop into primary hypogonadism, which does not respond to treatment, but it can be successfully prevented. For this, HCG (human chorionic gonadotropin) is used, which is available under the trade names Pregnyl, Profazi, Horagon, etc. 4 weeks of HCG cycle is enough to prevent the development of testicular atrophy. The use of gonadotropin during a long cycle (longer than 6 weeks) is recommended by many experts. Already existing testicular atrophy is treated only symptomatically. Testosterone replacement therapy is used to replenish the lack of testosterone.

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Creatine for bodybuilding

Creatine is a natural molecule found in muscles and is required for energy metabolism and movement. The human body contains about 100-140 g of this substance, which serves as an energy source for muscular contraction. The daily consumption of creatine under normal conditions is approximately 2 g. It can be synthesized by the body independently from glycine, arginine and methionine, which are natural protein components.

In humans, enzymes involved in its synthesis are localized in the liver, pancreas, and kidneys. It can be produced in any of these organs, and then transported by the blood to the muscles. Approximately 95% of the total creatine is in skeletal muscles.

With increasing physical activity, the consumption of creatine also increases. Its supply must be replenished through diet or through the body’s own natural production. The immediate source of energy for the contraction of skeletal muscle is a molecule called ATP.

When ATP releases energy for muscle contractions, the phosphate group is cleaved off and a new molecule called ADP  is formed. This process is reversible with creatine phosphate. Creatine combines with phosphate in the cell to form phosphocreatine.

Effects of creatine

Increased strength

In bodybuilding, during high-intensity exercise, the need for ATP in working muscles increases significantly – hundreds of times higher than at rest. Depleted stores of ATP and phosphocreatine must be continually replenished in order for muscle contractions to continue at peak levels of frequency and strength. Thus, by taking creatine, you can increase the amount of ATP and accordingly muscle strength.

Increased muscle mass

Recent experiments prove that creatine monohydrate is able to increase the repetition maximum in the bench press by 10 kg after a week of intake, and improve sprint ability. The increase in strength allows you to achieve the maximum growth-stimulating effect on the muscles. However, it should be noted that taking creatine does not always have this effect due to individual sensitivity of the body to creatine.

Muscle quality

Creatine monohydrate binds to water as it is absorbed into muscle cells. As more creatine is stored, more water is drawn into the muscle cell. This explains the hydrating effect of creatine on muscle cells, which are approximately 75 percent water. Bodybuilders notice that a well-hydrated muscle looks fuller, rounder, and more pumped outwardly.

When muscle cells increase in volume due to overhydration, protein synthesis is increased and protein breakdown is minimized (this can also increase glycogen synthesis).

Increased secretion of anabolic hormones

Research shows that creatine can increase the secretion of endogenous anabolic hormones in response to exercise. These hormones are represented by growth hormone and testosterone. Moreover, the level of growth hormone increases only 2 hours after taking creatine. Such a delay may indicate that the release of growth hormone does not depend on creatine itself, but is of an indirect nature and arises as a result of a cellular response. Also it increases the secretion of insulin-like growth factor by 15% compared to the placebo group. The formation of myostatin is significantly suppressed. Creatine also increases the level of dihydrotestosterone.

Lactic acid buffer

There is evidence that creatine also works as a lactic acid buffer. During intense anaerobic workouts, the muscles secrete lactic acid, this substance is partly responsible for the burning sensation that occurs when the muscle is working to failure. In recent studies it was shown that creatine can inhibit lactic acid secretion and action and improve recovery time after short-term intense exercise (for example, strength training).

Other positive effects of creatine

  • Supplementation with creatine has a positive effect on reducing total plasma cholesterol, triglycerides and very low density lipoproteins (protection of the cardiovascular system);
  • It may have anti-inflammatory effects in acute inflammation, local irritation, and chronic conditions of inflammation;
  • Creatine / phosphocreatine system has a protective effect on the central nervous system during ischemia and in hypoxic conditions;
  • Creatine supplementation is used to treat diseases that cause muscle wasting, creatine depletion, and neuromuscular disorders;
  • Creatine is being investigated for potential in inhibiting the growth of certain types of tumors in mammals. Some studies suggest that creatine may have some anti-cancer activity;
  • Supplementation with creatine has a positive effect on the athletic performance of vegetarians;
  • In chronic heart failure, cardiac creatine levels decrease; Supplementation with creatine in such symptomatic patients increases the amount of energy-rich phosphocreatine in skeletal muscle and therefore performance in terms of strength and endurance. In fifty patients who underwent heart valve replacement surgery, creatine supplementation reduced arrhythmias by 75%.

Who needs creatine?

  1. Creatine for athletes

Creatine is good for short-term athletic performance, for example, in sprinting, cycling, strength sports and, of course, in bodybuilding. Creatine is suitable for sports that require jumping, speeding up. Team sports such as basketball, football, hockey, as well as martial arts, tennis, athletics and sprint running are also characterized by short explosive muscle contractions followed by short rest or recovery periods.

Apparently, creatine helps maintain a high level of rapid energy supply to the body. It also prevents the build-up of plasma ammonium ions, which would otherwise slow down physical activity.

 

  1. Creatine for gaining muscle mass

Supplementing your diet with creatine can help an athlete train harder for a longer period of time. In turn, the increased intensity of muscle training generates faster muscle growth and strength. Creatine allows weightlifters to achieve an increase in muscle mass of 2 or more kg.

Many athletes taking creatine have noted an increase in water retention within muscle cells. This increases the volume of the cell and muscle tone, as a result the muscles are better trained. A strength sports athlete weighing 75 kg can increase his weight by 2-4 kg.

After stopping taking creatine, weight gain decreases again due to the increased excretion of water. However, due to better performance during training, some of the real gain in muscles remains.

  1. Creatine for vegetarians

Since vegetarians do not consume meat, which is the main source of creatine, therefore it is especially recommended. And here there is a problem not only of sports achievements in bodybuilding, but also of health.

  1. Creatine for weight loss

Creatine improves training results, strength, recovery rate, speed, and, as a result, accelerates the loss of fat.

 

Creatine and children

It is better to postpone the use of creatine until the end of puberty. The thing is that that the long-term effects of creatine are still not well understood. In other words, if long-term side effects of creatine exist, then younger athletes who use it in their practice will be more susceptible to these adverse reactions than adults. Thus, creatine can only be used safely after puberty.

Creatine and the elderly

Muscle creatine levels decline with age, partly explaining the decreased strength and predisposition to fatigue seen in older adults. Creatine intake can stop these unwanted age-related changes. This view is supported by improvements in health and strength in people over 50 who used creatine. It is also important that the effectiveness of creatine supplementation increases with age.

Oddly enough, after the age of 70, the effectiveness of creatine begins to drop dramatically. This may be due to decrease in endogenous anabolic hormones, and reduction in the number of muscle fibers, which are the main consumers of creatine.

However, as it can be easily avoided through regular exercise. An active lifestyle will maintain high levels of anabolic hormones and prevent the loss of muscle fibers.

Additionally, creatine prevents the development of certain mental and neurodegenerative diseases of the elderly, reduces the risk of coronary heart disease, and improves DNA methylation.

However, you should remember that creatine in rare cases can slightly increase blood pressure, therefore you should monitor your blood pressure when taking creatine.

Creatine and girls

According to different studies the effect of creatine in women is less prominent than in men. This difference is explained by higher testosterone levels in men.

Thus, creatine can be recommended for women, especially when losing weight. It will increase the intensity of your workouts, and, therefore, accelerate the process of breaking down fat. In addition, creatine will preserve muscle mass, which begins to be actively lost during fasting. Therefore, creatine is useful not only for gaining muscle mass, but also for the formation of a beautiful female figure.

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Beste Bulking Sarms

Each of Selective Androgen Receptor Modulators (SARMs) has unique properties. Here we’ll discuss most popular ones and their benefits:

Ostarine (MK-2866) optimal for novices

Ostarine is an incredibly dynamic SARM which can prevent loss of muscles. It is good for those who suffer from lack of calories during drying cycles, as they can burn fat without reduction of muscle mass.

Due to its properties, ostarine is often used in medical practice for treatment of muscle loss in patients. However, athletes mainly use it for boosting strength and stamina and for prevention of muscle loss.

Usually ostarine cycle lasts for 8 weeks. The dose varies from 10 mg to 25 mg, and it’s better not to exceed it since it may suppress HPTA.

Radarine (RAD-140) – possibly one of the most powerful SARMs

Radarin, aka RAD-140, is rather new drug, but it gained popularity for fast results with low sides. It is mainly used for increasing muscle mass and strength, and is suitable for cutting and bulking cycles.

It can provide huge increase in strength, which can help you to overcome yourself. It also boosts energy thus you can do workouts for much longer.

Ligandrol (LDD-4033) – perfect for bulking

Ligandrol is mostly taken for bulking and is preferred for its long half-life, which is about 1-1,5 days, therefore you can take it only once a day. It is also famous for low sides and as a powerful fat burner.

 

Cardarin (GW501516) perfect for cutting

 

Cardarine is used for increasing endurance and as a fat burner. It also reduces bad cholesterol in the blood. In medicine it is used to protect cerebral blood vessels from damage and stress, as well as to fight obesity.

 

Best SARM cycles for Cutting

MK-2866 Ostarine 20 mg / day along with Cardarine 10 mg / day for 2.5 months. This combo is perfect for keeping muscle mass, fat-burning, and endurance.

MK-2866 Ostarine 20 mg / day along with LGD-4033 Ligandrol 10 mg / day for two months. This combo can help you to increase muscle volume and to avoid of muscle loss.

SARM cycles for bulking

LGD-4033 Ligandrol 10 mg / day along with RAD140 10 mg for 2 months cycle. It provides fast bulking, with very low sides.

S23 10 mg, RAD-140 10 mg and Ibutamoren 20 mg / daily for an 2 months cycle. It can help you to gain mass extremely fast. Ibutamoren also boosts Growth Hormone levels which has additional benfits.

Best SARM cycles for cutting

LGD-4033 Ligandrol 10 mg in combo with GW501516 cardarin 10 mg daily for an 2 months cycle. This combo is powerful fatburner and also reduces water retention, besides it lowers bad cholesterol in the body.

Best SARM cycles for strength

RAD140 – 10 mg and S23 at 10 mg / day for 2 months cycle. This combo is perfect for muscle gaining and can be incredibly beneficial for power and strength.

YK-11 10 mg and LGD-4033 10 mg for 2 months. This combo is exceptional for increasing pure strength and muscle mass with low sides.

 

In order these SARMs to work effectively, one should train properly and combine the cycles with healthy habits and lifestyles. Also do not forget to eat proteins every day, especially after workout.

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Arimidex-Dosierung während des Zyklus

Arimidex (Anastrozole) is an aromatase inhibitor, an enzyme that converts testosterone to estradiol. When used with anabolic drugs, Anastrazole minimizes the side effects of estrogen.

Anastrazole controls the level of this female sex hormone, it also increases the levels of free testosterone. The drug is safe and well tolerated when correct doses are used.

  • Reduces estrogen levels
  • Increases the effectiveness of steroid hormones.
  • Promotes natural testosterone synthesis even with androgen steroids.
  • Prevents gynecomastia in men.

Pharmacodynamics

The non-steroidal active ingredient selectively blocks aromatase. In postmenopausal women, folliculin, androstenedione and aromatase promote estradiol synthesis.

With a decrease in the estradiol level, breast cancer is treated. The estradiol level is reduced by 80%. The drug has no progestogenic, estro or androgenic activity.

When the tablets are taken orally, the active substance is rapidly absorbed from the gastrointestinal tract. Its binding to plasma proteins will be 40%. Accumulation in the body does not occur. The maximum concentration in the blood will reach after 2 hours if the agent is taken on an empty stomach.

Dealkylation, hydroxylation, glucuronidation ensure the absorption of the drug by the liver. Urine and blood contain the main metabolic product, triazole. Excretion of drug metabolites is 3 days.

Benefits and harm

  • Anastrozole removes unnecessary fluid from the body.
  • It has a positive effect on blood cholesterol profile.
  • Increases libido in men.
  • Prevents arterial hypertension.
  • Decreases estrogen dependent inhibition of the pituitary-hypothalamus-testicles axis.
  • The remedy is popular for PCT during the recovery period.
  • The medicine helps well with hormone replacement therapy.

One should remember that estradiol is needed by the body for normal functioning. Therefore, it is important for an athlete to remember about biological role of estradiol and to keep it on the proper level.

 

The low estrogen levels may cause

  • Memory impairment
  • Mood changes
  • The problems with joints
  • Depression.
  • Decreased Libido.
  • The cholesterol level will rise.

 

How to take it right

The tablets are indicated for bodybuilders with experience after a cycle of anabolic steroids at maximum dosages. The medicine is used in two cases: before the cycle of anabolic steroids for prophylaxis with therapeutic doses, and after the cycle, to prevent the side effects of steroids.

The tablets should be taken on an empty stomach with a large volume of water. In this case, the active ingredient will quickly enter the bloodstream from the digestive system.

On the cycle, Anastrozole should be taken every other day during 2 weeks. The optimal dosage for good athletic performance does not exceed 250 mcg once every 2 days.  To reduce the estardiol level by half, a dose of 0.5-1 mg is recommended. For preventive measures in bodybuilding, 0.5 mg is enough every other day.

For gynecomastia 1 mg is used until the symptoms are eliminated, then 0.5 mg every other day. It is important to remember that not all anabolic steroids are aromatized. For example, in Anadrol, the transformation into estrogens is insignificant.

When using anabolic steroids with a short half-life, like Methandrostenolone, after 10 days, an analysis is made for the concentration of estradiol in the blood, Anastrozole is taken at 0.5 mg every other day. Then, after 10 days, estradiol is examined, the dose is adjusted.

When using anabolic steroids with long esters, for example, Sustanon, the dosage is 0.5 mg every other day. It is required to make a test for estradiol in 3 or 4 weeks after beginning of a cycle. The control analysis is carried out approximately in 10 or 14 days after you start taking Anastrozole. You should decrease the dosage if side effects are observed.

You should not combine Tamoxifen with Anastrozole. With such drug interactions, there is a mutual weakening of these drugs. It is forbidden to consume alcohol with Anastrozole, otherwise, with such compatibility, the pharmacological effect of the drug will not appear, undesirable consequences will appear.

 

Post-Cycle-Therapie

It is important to remember that drugs that inhibit aromatase are not used in post-cycle therapy, they are used during the cycle and after the use of anabolic steroids (before PCT).

 

During PCT, drugs that block estrogen receptors (Clomid, Tamoxifen) are taken after a cycle for 2-3 weeks. Tamoxifen requires 10-20 mg per day, or Clomid 25-50 mg per day is used. The dose is gradually reduced towards the last week.

 

Thanks to chorionic gonadotropin, testicular atrophy can be prevented. It is used for heavy cycles, the duration of which is more than 6 weeks. It is introduced on the last 4-5 weeks of the cycle and should be used until discontinuation of steroids. Then you need to switch to drugs that block estrogen receptors.

 

The use of Cabergloline is recommended during cycles with progestin drugs, due to which the prolactin level increases. The dosage is 0.25 mg every 4 days for the entire cycle.