A new study published in the journal OncoImmunology revealed that Viagra in a combination with flu vaccine can be efficient in fighting metastatic cancer.
These two rather inexpensive and clinically approved drugs may become a solution of major obstacle in fighting cancer. If clinical trials confirm this discovery, Viagra + vaccine can solve the immunity problem, which occurs after operation.
Initially scientist developed Viagra to improve blood flow to cardiac muscle. However, it came into medical practice as a treatment for erectile dysfunction. Recent experiment showed that it can be a powerful tool against more dangerous diseases.
Moreover, the hidden properties of this “universal” drug continue to reveal themselves. For instance, several years ago scientists found out that sildenafil (the major agent of Viagra) can be antimicrobial.
Cómo funciona
Today we know that Viagra suppresses the activity of PDE-5 – enzyme, which regulates the blood flow into penis. It also controls the functioning of different immune cells. After operation for tumor removal numerous immune mechanisms become suppressed. Therefore, researchers suggested that by suppressing this enzyme they can restore the function of immune cells.
In this study a group of researchers tested different combinations of sildenafil and other drugs on mice with aggressive types of cancer. When cancer was at a stage of metastasis, scientists excised the tumor and injected high dosage of sildenafil combined with vaccine, which became a lure for immunity.
They discovered that without treatment the quantity of metastases increased from 40 to 150, which led to quick death of an animal. In case of treatment with Viagra, the quantity of metastases reduced to 11. Therefore, the blocking of PDE 5 stimulates activity of “killer cells” which are responsible for fighting cancer.
Now researchers are planning to conduct 1st stage of clinical trials with 24 volunteers from Ottawa hospital. In case of success, Viagra will become one of the most efficient tools against cancer.
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