Brufen (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid that has been shown to be effective by inhibiting prostaglandin synthesis. In humans, ibuprofen reduces pain associated with inflammation, swelling, and fever. In addition, ibuprofen inversely inhibits platelet aggregation. Experimental evidence suggests that ibuprofen can competitively suppress the effect of low-dose aspirin (acetylsalicylic acid) on platelet aggregation when these drugs are used concomitantly.
Some pharmacodynamic studies show that when using single doses of ibuprofen 400 mg within 8 hours before or 30 minutes after using aspirin (acetylsalicylic acid) immediate release (81 mg), there was a decrease in the effect of aspirin (acetylsalicylic acid) on thromboxane formation or platelet aggregation. Although there is uncertainty about the extrapolation of these data to the clinical situation, it cannot be ruled out that regular long-term use of ibuprofen can reduce the cardioprotective effect of low doses of acetylsalicylic acid. With the occasional use of ibuprofen, such a clinically significant effect is considered unlikely.
Ibuprofen relieves pain, reduces inflammation, and lowers fever.
For oral administration. The minimum effective dose should be used for the short period necessary to relieve pain (no more than 5 days) or fever symptoms (3 days). If you need to use the drug for more than 5 days (if the symptoms persist), you should consult a doctor.
The drug is prescribed for adults and children weighing more than 20 kg (from about 6 years old).
How to take
Usually used at the rate of 20 to 30 mg / kg of body weight per day. Do not exceed a dose of 30 mg / kg body weight per day.
Children weighing from 20 to 30 kg (from 6 to 11 years old) – 200 mg (1 tablet), a repeated dose, if necessary, after 6 hours, but in any case, do not use more than 600 mg (3 tablets) per day.
Adults and children weighing more than 30 kg apply 200-400 mg (1-2 tablets) every
4-6 hours if necessary. The tablets must be taken with water. Do not use more than 1200 mg (6 tablets) in 24 hours.
Elderly patients do not need special dosing.
Patients with mild to moderate renal and hepatic impairment do not require dose adjustment.