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This substance is used in medicine to treat bronchial asthma. In recent years, this product has been widely used in sport, especially in fitness and bodybuilding due its far-burning abilities. This is the reason it is used by athletes for dropping weight and making definition. Clenbuterol cycles often include thyroid hormones and ketotifen to make fat-burning process much faster. Clen is different from anabolic steroids by nature. It belongs to the group of medicines called adrenomimetics. They produce their physiological effect by stimulating beta-two-adrenergic receptors. This produces activation effect on the sympathetic nervous system and triggers lipolysis.
Effects of clenbuterol
- Clen burns fat and make definition on muscles
- Increases power and endurance
- It increases metabolism and rises body temperature
- It suppresses appetite
- Clen activates psychic processes
- This product has anti-catabolic action
- And also good anabolic action
Practice shows that irreversible side effects are almost completely absent. Low incidence of side effects and a wide range of positive effects makes it one of the best fat burners in bodybuilding.
Some authors like famous Russian bodybuilder Yuri Bombela argue that in large doses this substance can have catabolic, i.e.muscle cells destroying effects, but this is not true, due to the absence of any physiological or empirical justification.
Cycle: weight reduction or cutting
In males the advised dosage of this product for cutting and burning mass is from 120 to 140 mcg every day. For females, the common amount of clenbuterol for definition and cutting weight is from 80 to 100 mcg daily. The cycle of clenbuterol possesses its own unique points that must be controlled with respective attention in order to not to experience negative side effects.
Normally, you should use it for two weeks. This is a time after what the receptors develop addition. It is also called receptor tolerance and thus the effectiveness of the product decreases. In order to parry this you need to take a two week pause and use ketotifen. Without ketotifen the break is notably less effective. Then you need to do one more two-week cycle without ketotifen, off-time after second part should be much longer.
The need for a pause has been scientifically proven in 90es. Desensitization of beta-adrenergic receptors develops due to phosphorylation of them and through other biochemical modifications at the level of secondary messengers (kinases, G-proteins, etc.). It takes several days to update these structures.
The time length and effectiveness of the clen cycle, as mentioned, can be improved by adding of ketotifen. Sometimes, to avoid adaptation of the receptors, a switch scheme is recommended — you are two days on and two days off, but this program is less effective.
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