Pregnyl (HCG)

Beskrivelse

HCG er ikke et anabole / androgene steroid, men et naturlig proteinhormon som utvikler seg i morkaken til en gravid kvinne. HCG dannes i morkaken umiddelbart etter nidasjon. Det har luteiniserende egenskaper siden det er ganske luteiniserende hormonet LH i fremre hypofysen. I løpet av de første 6-8 ukene av svangerskapet gir det dannede HCG mulighet for fortsatt produksjon av østrogener og gestagener i de gule kroppene (corpi luteum). Senere produserer morkaken selv disse to hormonene.

Hvordan det fungerer

HCG is manufactured from the urine of pregnant women since it is exereted in unchanged form from the blood via the woman`s urine, passing through the kidneys. The commercially available HCG is sold as a dry substance and can be used both in men and women. In women injectable HCG allows for owlation since it influences the last stages of the development of the ovum, thus stimulating ovulation. It also helps produce estrogens and yellow bodies. The fact that exogenous HCG has characteristics almost identical to those of the luteinizing hormone (LH) which, as mentioned, is produced in the hypophysis, makes HCG so very interesting for athletes. In a man the luteinizing hormone stimulates the Leydig`s cells in the testes this in turn stimulates production of androgenic hormones (testosterone). For this reason athletes use injectable HCG to increase the testosterone production. HCG is often used in combination with anabolic/androgenic steroids during or after treatment. As mentioned, oral and injectable steroids cause a negative feedback after a certain level and duration of usage. A signal is sent to the hypothalamohypophysial testicular axis since the steroids give the hypothalamus an incorrect signal. The hypothalamus, in turn, signals the hypophysis to reduce or stop the production of FSH (follicle stimulating hormone) and of LH. Thus, the testosterone production decreases since the testosterone-producing Leydig`s cells in the testes, due to decreased LH, are no longer sufficiently stimulated. Since the body usually needs a certain amount of time to get its testosterone production going again, the athlete, after discontinuing steroid compounds, experiences a difficult transition phase which often goes hand in hand with a considerable loss in both strength and muscle mass. Administering HCG directly after steroid treatment helps to reduce this condition because HCG increases the testosterone production in the testes very quickly and reliably. In the event of testicular atrophy caused by megadoses and very long periods of usage, HCG also helps to quickly bring the testes back to their original condition (size). Since occasional injections of HCG during steroid intake can avoid a testicular atrophy, many athletes use HCG for two to three weeks in the middle of their steroid treatment. It is often observed that during this time the athlete makes his best progress with respect to gains in both strength and muscle mass. The reasons for this is clear. On the one hand, by taking HCG the athlete`s own testosterone level immediately jumps up and, on the other hand, a large concentration of anabolic substances in the blood is induced by the steroids. Many bodybuilders, powerlifters, and weightlifters report a lower sex drive at the end of a difficult workout cycle, immediately before or after a competition, and especially toward the end of a steroid treatment. Athletes who have often taken steroids in the past usually accept this fact since they know that it is a temporary condition. Those, however who are on the juice all year round, who might suffer psychological consequences or who would perhaps risk the breakup of a relationship because of this should consider this drawback when taking HCG in regular intervals. A reduced libido and spermatogenesis due to steroids in most cases, can be successfully cured by treatment with HCG.

De fleste idrettsutøvere bruker imidlertid HCG på slutten av behandlingen for å unngå en "krasj", det vil si for å oppnå best mulig overgang til "naturlig trening." En forutsetning er imidlertid at steroidinntaket eller doseringen reduseres sakte og jevnt før du tar HCG. Selv om HCG forårsaker en rask og betydelig økning av det endogene plasmatestosteronnivået, er det dessverre ikke et perfekt middel for å forhindre tap av styrke og masse på slutten av en steroidbehandling. Idrettsutøveren vil bare oppleve en forsinket omjustering, som ofte har blitt observert. Selv om HCG stimulerer endogen testosteronproduksjon, hjelper det ikke å gjenopprette den normale hypotalamus / hypofyse testikkelaksen. Hypothalamus og hypofysen er fortsatt i en ildfast tilstand etter langvarig steroidbruk, og forblir slik mens HCG brukes, fordi det endogene testosteron produsert som et resultat av det eksogene HCG undertrykker den endogene LH-produksjonen. Når HCG er avviklet, må utøveren fortsatt gjennomgå en omjusteringsperiode. Dette er bare forsinket av HCG-bruken. Av denne grunn tar erfarne idrettsutøvere ofte Clomid og Clenbuterol etter HCG-inntak, eller de begynner umiddelbart en annen steroidbehandling. Noen tar HCG bare for å få av "steroider" i minst to til tre uker. Mange kroppsbyggere er dessverre fremdeles av den oppfatning at HCG hjelper dem med å bli hardere mens de forbereder seg på en fullføring ved å bryte ned subkutant fett slik at fordypninger og vaskularitet blir bedre utsatt. HCG-pakningsvedlegget sier tydelig at HCG ikke har noen kjent effekt av fettmobilisering, appetitt eller sultfølelse eller kroppsfettfordeling. HCG har ikke vist seg å være effektiv tilleggsbehandling ved behandling av fedme, det øker ikke fett tap utover det som skyldes kaloribegrensning.

Doser

Idrettsutøveren bør innrette en HCG-ampulle (5000 IE) hver 5. dag. Siden testosteronnivået, som forklart, forblir betydelig forhøyet i flere dager, er det unødvendig å injisere HCG mer enn en gang hver 5. dag. Den relative dosen er etter idrettsutøverens skjønn og bør bestemmes basert på varigheten av hans forrige steroidinntak og styrken til de forskjellige steroidforbindelsene. Idrettsutøvere som tar steroider i mer enn tre måneder og idrettsutøvere som først og fremst bruker sterkt androgene steroider som Anadrol, Sustanon, Cypionate, Dianabol (D-bol), etc., bør ta en relativt høy dose. Den effektive dosen for idrettsutøvere er vanligvis 2000-5000 IE per injeksjon og bør, som allerede nevnt, injiseres hver 5. dag. HCG bør bare tas i 4 uker. Hvis HCG tas av mannlige idrettsutøvere over mange uker og i høye doser, er det mulig at testiklene reagerer dårlig på et senere HCG-inntak og en frigjøring av kroppens egen LH. Dette kan resultere i en permanent utilstrekkelig kjønnsfunksjon. Sykluser på HCG bør holdes nede til rundt 3 uker om gangen med en av-syklus på minst en måned i mellom. For eksempel kan man bruke HCG i 2 eller 3 uker midt i en syklus, og i 2 eller 3 uker på slutten av en syklus. Det har blitt spekulert i at langvarig bruk av HCG permanent kan undertrykke kroppens egen produksjon av gonadotropiner. Dette er grunnen til at korte sykluser er den beste måten å gå.

Bivirkninger

HCG can in part cause side effects similar to those of injectable testosterone. A higher testosterone production also goes hand in hand with an elevated estrogen level which could result in gynecomastia. This could manifest itself in a temporary growth of breasts or reinforce already existing breast growth in men. Farsighted athletes thus combine HCG with an antiestrogen. Male athletes also report more frequent erections and an inereased sexual desire. In high doses it can cause acne vulgaris and the storing of minerals and water. The last point must especially be observed since the water retention which is possible through the use of HCG could give the muscle system a puffy and watery appearance. Athletes who have already increased their endogenous testosterone level by taking Clomid and intend subsequently to take HCG could experience considerable water retention and distinct feminization symptoms (gynecomastia, tendency toward fat deposits on the hips). This is due to the fact that high testosterone leads to a high conversion rate to estrogens. In very young athletes HCG, like anabolic steroids, can cause an early stunting of growth since it prematurely closes the epiphysial growth plates. Mood swings and high blood pressure can also be attributed to the intake of HCG. HCG is also suitable as “over bridge” doping before a competition with doping controls. HCG`s form of administration is also unusual. The substance choriongonadotropin is a white powdery freeze-dried substance which is usually used as a compress. Based on the low structural stability of this compress it can easily fall apart, thus giving the impression of a reduced volume. This is, however, insignificant since there is neither a loss in effect nor a loss of substance. Each package, for each HCG ampule, includes another ampule with an injection solution containing isotonic sodium chloride. This liquid, after both ampules have been opened in a sterile manner, is injected into the HCG ampule and mixed with the dried substance. The solution is then ready for use and should be injected intramuscularly. If only part of the substance is injected the residual solution should be stored in the refrigerator. It is not necessary to store the unmixed HCG in the refrigerator however, it should be kept out of light and below a temperature of 25&deg C. HCG is a relatively expensive compound. Pregnyl costs approx.$36 -45 for 3 ampules of 5000 I.U. each and the relative solution ampules. The other compounds have a similar price and are $12 -15 for 5000 I.U. The 5000 I.U. ampules are the most economic and, in our opinion, also the most sensible for bodybuilders, powerlifters and weightlifters. There are currently only a few fakes of HCG. Since the dry substance of HCG is somewhat similar to the dry substance of Somatropin often “cheap” HCG is sold as “expensive” HGH on the black market.