GHRP-2

La description

Buy GHRP-2 (Growth Hormone Releasing Peptide-2) is a stimulant for the short-term but intense release of endogenous growth hormone .

GHRP-2 is an oligopeptide containing 6 amino acids linked by amide bonds. Possessing a small molecular weight, this peptide has the ability to penetrate through the mucous membrane into the vessels of the oral cavity and enter the circulatory system bypassing the gastrointestinal tract. The ability of GHRP-2 to stimulate the release of STH increases its level by 7-15 times, it also showed higher efficiency indicators compared to GHRP-6, which is proved by scientific research of the Italian University of Turin in 1997, as well as research by Brazilian scientists in 2012.

MECHANISM OF ACTION

GHRP-2 is a member of a group of oligopeptides that interact with the seven-coil receptors of the pituitary gland and hypothalamus, and this peptide also actively affects ghrelin receptors, which suggests the launch of a cascade of ghrelin-mediated reactions associated with increased appetite, improved myocardial function, reduced inflammatory responses, and immunomodulatory effects.

GHRP-2, like the rest of this group of peptides, was obtained from met-enkephalin (one of the neuropeptides produced in corticotropic cells of the pituitary gland and possessing opioid properties), but neither GHRP-2 itself nor drugs from its group have opioid properties. Despite the fact that there is no structural homology between GHRP-2 and somatoliberin (a natural polypeptide synthesized in the arcuate and ventromedial centers of the hypothalamus responsible for the release of GH), clinical testing of this peptide has shown a stimulating GH release similar to somatoliberin on the pituitary gland.

GHRP-2, having a small size, excellently penetrates mucous membranes with a well-developed vascular network (oral and nasal cavity), which makes it possible to effectively use this class of peptides by several methods of administration that are more convenient for the user, which is proved by scientific studies published in 1995 in journal Endocrinology and Metabolism. Also, the results of clinical trials, which appeared in the same journal in 1997, show the same activity of GHRP-2 in individuals of different ages (children, adults and the elderly), so the relevance of using GHRP-2 is not lost with aging.

EFFECTS

1. Significant release of growth hormone (increase in concentration by 7-15 times)

2. Increased appetite (due to the action similar to ghrelin)

3. Reduction of adipose tissue and increase in muscle (due to stimulation of growth hormone)

4. Stabilize cholesterol

5. Increases bone density

6. Rejuvenation of the skin (due to the stimulation of STH, which entails increased collagen synthesis)

7. Protective effect on the liver

8. Immunomodulatory properties, which entails, among other things, the weakening of inflammatory reactions (ghrelin effect)
9. Improving the function of the heart muscle (ghrelin effect)

GHRP-2 administration

Several different studies with GHRP-2 showed a direct relationship between the peptide dose and the effect of the release of GH, therefore, the recommendation for calculating the effective dosage of the peptide is 1-2 μg per 1 kg of body weight with a frequency of taking 3 times a day (that is, a person weighing 100 kg should inject 100-200 μg of GHRP-2 three times a day). As a rule, the intake occurs before meals, after physical activity and immediately before bedtime. Some athletes took 1000 mcg of GHRP-2 per day without any side effects. However, it should be taken into account that the dose-effect relationship begins to decrease at doses above 200 μg, at the same time the production of glucocorticoids and prolactin increases.

GHRP-2 combinations

It seems to be an effective way to increase the effectiveness of GHRP-2 by taking other drugs that stimulate the production of GH, such as modified (tetrasubstituted) sermorelin or CJC 1295 DAC. The use of several peptides to stimulate growth hormone allows potentiation (enhancement) of their effect. For example GHRP-2 100-150 mcg three times a day + CJC 1295 DAC 1000 mcg twice a week for 5-7 weeks.

Also, in order to achieve a synergistic effect, it is possible to use other stimulants of GH, such as GABA, glutamine, nicotinic acid + vitamin B6, in certain cases insulin (if there is enough knowledge and experience of its use, and there is also a goal of maximum mass gain, even to the detriment of its quality).

GHRP-2 optimum combination

GHRP-2 100-150 mcg three times a day + CJC 1295 DAC 1000 mcg twice a week + MGF PEG 200 mcg to the target muscle group after training.