In MOST cases the difference between cheaper and more expensive
manufacturers is not the substance itself (we are not talking about kitchen or basement “laboratories”) but oils used – big pharmaceutical giants certainly make it not painful, no irritation, etc. Sometimes (rarely) quality problems occur with top underground laboratories like with deceased British Dragon or even with small legal manufacturers like Balkan. This is not system, this is not often but such problems are unbelievable with Organon or Schering. So, double price normally means insurance against problems and convenience of usage, but not duplicate effect. And some UG labs are tempted to underdose the most expensive products, so reputation of particular laboratory should be studied before use, in the past we had some brands removed because of that.
Pharm grade (pharmaceutical giants) vs underground laboratories (UG labs)
March 3rd, 2013Wjat is the difference between Human Grade and Vet Grade
January 30th, 2013
Article taken from http://www.steroidology.com/forum/anabolic-steroid-forum/76253-difference-between-human-grade-vet-grade.html
I had a discussion about this with someone recently and I realize that there is probably a lot of others out there that don’t realize what the difference between human grade and vet grade really means.
For most people, they really don’t care about the difference between the two. They figure, “well if it is good enough for animals, it must be good enough for humans!” IE, if it doesn’t seem to kill animals, then it won’t kill me!
First off, Human grade is “pharmaceutical Grade”. Pharmaceutical grade is defined as: Pharmaceutical Grade – meets pharmaceutical standards. There are several criteria by which pharmaceutical grade is judged. The product must be in excess of 99% purity with no binders, filters, dyes, or unknown substances.
Standards are regulated by a number of organizations including the FDA in the US. But there are different standards for Veterinary and pharmaceutical products within and outside of the United states. For example, in the supplement industry, the quality standards differ for both production and formulation of drugs and supplements. In example of r ALA, the american and european standard is 99% purity, where in other places it is as low as 90%. Beyond that, the production standards can be quite different. The highest quality for standards of production, packaging and compounding comes from the United States Pharmacopeia specifications (USP). USP standards have long been respected and trusted within the scientific and manufacturing community.
The standards of production for animals and humans are definitely different. One of the main examples is the purity standards for the compound and the contaminent level. For human pharmaceutical grade, the standards are so high as to limit the amount of any contaminent in the compound. For animals, it is much lower, meaning that there can be found contaminants that would never meet the Human standards. It is much cheaper to produce a veterinary grade product. An easy example of this would be in the holding tanks for the solutions. A veterinary grade solution could be held in an aluminum tank, where aluminum could leach off into the solution. A human grade solution would be required to be held in a glass lined tank to prevent metal contamination. Now, of course the metal contaminent would be in relatively low levels, but with frequent human use of this solution, aluminum levels could continue to build up in the system over time causing a whole host of health problems. Aluminum poisoning has been linked to Dementia in humans as well as hair loss. (1). Citric acid and fluoride allow aluminum to pass the blood brain barrier, and both are readily ingested by humans on a continual basis.
That is just one example of a contaminent that can easily be found in a veterinary grade product.
It goes beyond the tanks as well. Oftentimes, a facility is producing multiple veterinary drugs and cross contamination can occur as well, such that the components of one drug is found in small amounts in another via equipment transfer. The human grade products and especially USP have very strict controls on the sterility of the equipment used to manufacture drugs so that this will not occur.
The bottom line is that one should pay attention to whether or not a compound is Human grade or vet grade. The best indication of whether or not a compound is of high quality is if it is labeled “USP” beyond that, one should look for the country of origin, and the intended use of the product, be it for animals or humans.
For products like B12, I would not buy anything that was not intended for humans. B12 is made in bulk and the aluminum vs glass tanks is a very real concern. Research-Ology.com B12 is absolutely human grade and even though it is more expensive than vet grade, I would pay it. It isn’t worth alzheimers disease. The CEMlabs products are all USP grade. Research-Ology.com products are all human pharmaceutical grade with a minimum of 99% purity. The DMSO that cemproducts is bringing on is USP grade, and there is only one place to get it. If you use DMSO, you would be a fool to use anything else than USP grade. Other DMSO is intended for use as an industrial solvent, so there are absolutely no restrictions governing quality control at all! For something that is permeating your skin and going right into your system, you owe it to yourself to get the highest quality stuff you can.
For steroids, I would be cautious, but considering what exactly goes into the process, I wouldn’t worry TOO much unless you are cycling more than a couple of times a year. Most steroids consist of an oil, BA and/or BB (which is a sterilizer) and then the steroidal compound itself. In that case, you would most likely only need be concerned with the quality of the steroidal componenet and possibly the oil. If you make it yourself, then you have even greater control.
Article comments:
Originally Posted by LeanMeOut
Research-Ology.com B12 is absolutely human grade
I’m sure the research-ologies B12 is good and safe, but it is not human grade as it is not subject to oversight by the respective regulating body, the FDA.
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Very good info, makes me rethink the QV products that are readily available to me. I don’t cycle more than 1-2 times a year so I should be fine
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Where do we put UG labs, In the middle or some where else?
…and with UG labs, I would think you’d have to seperate them into at least two categories; 1 – real UG labs, and 2 – basement or kitchen set ups.
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The thing about any UG lab is that UG labs aren’t subject to oversight, documentation standards, etc. So, you just don’t _know_ how good and clean their product is. And just because batch #1 from an UG lab is good doesn’t mean that batch #2 will be the same.
A few months ago I suggested that it was possible for an UG lab to produce a clean, sterile product that some might call ‘human grade.’ In response, I was told that human grade means pharmaceutical grade. So be it; I have corrected my understood definition of ‘human grade’.
Buying medications with credit card. Buying steroids with VISA. Pharmacy lobby conspiracy
October 23rd, 2012We already discussed that since 2007 VISA and MasterCard strictly prohibit selling steroids through their systems and they watch that well using spies and sophisticated computerized technologies. Do not trust when someone like steroid.com and its affiliates try to sell you “legal steroids” and other bullcrap like that, believe me, if they had really dealt with steroids they would be quickly caught, fined and jailed. Such companies cheat customers and sell merely vitamins and food supplements under steroid-like brand names.
Ok, let’s forget about steroids. Pharmaceutical industry is multi, multi, multibillion business in the world and particularly in US. And greed of big manufacturers is really without limits. Why do you think they do “treatment”, often lifelong instead of “curing” patient? Because their cash inflows are also lifelong in that case. Small legal manufacturers used to have their own share of the market as well as non-US manufacturers and even underground manufacturers, which often had much lower prices comparing to big companies. But just as I mentioned, greed of pharmaceutical giants is incredible. They want to have it all, to have YOU all.
Because of this, every year it became more and more difficult to sell ANY medications over the Internet, because ALL payment systems are being targeted by US authorities, but roots of the problem are mostly US pharmaceutical giants.
However, this September-October (2012) really amazing and wonderful thing happened. US pharmacy lobby pressed on VISA and MC, so it seems that now even EU-based companies of LEGAL medications cannot use credit cards without FDA approval (despite FDA is US, not EU authority), so now you can buy with your card only FDA-approved drugs, not listed in DEA Schedules and only from US FDA-approved pharmacy. This could be funny if it had not be too sad. Although this seems very unfair, but that lobby has a power to execute such a decision. Now they have most of US market and gonna have big share of online markets in other regions.
Why in the modern world of global economy all most popular global payment systems are located just in one country? If there were something like Visa in EU or Asia and accepted worldwide, there would be no possibility of such pressure. I have no other answer but conspiracy theory like New World Order, masons, etc. And I have nothing against pure American citizens because they suffer in first turn overpaying for simple meds now because there is really no fair competition on the market anymore.
HGH/IGF/MGF+steroid cycle
October 23rd, 2012Very powerful and very expensive peptide/steroid cycle that provides decent lean muscle mass gains along with
substantial fat-burning effect, which means you are getting not only muscles but also relief.
PEG-MGF (pegylated Mechano Growth Factor)
IGF-1 LongR3 (Insulin-like growth factor)
HGH (Human Growth Hormone)
Anavar (Oxandrolone)
Primobolan Depot (Methenolone enanthate)
6-7 a.m. HGH 4-5 IU / ED (if doing EOD then 8-10 IU)
~ 1 p.m. HGH 4-5 IU / ED (if doing EOD then 8-10 IU)
Anavar 25-40 mg/ED – at morning
AFTER WORKOUT – IGF-1 – 20-40 mcg every morning
Primobolan Depot 600-700 mg/ week (one-two weekly injections)
HGH – we believe that EOD shots are more effective comparing to ED shots
In case of pain and other sides – DECREASE DOSAGE.
L-thyroxine (Levothyroxine Sodium,T4)
September 15th, 2012Levothyroxine sodium
is an excellent fat burner since your metabolism is greatly increased while being on it. You can afford to be a little sloppier on pre-contest dieting since it will still burn fat when you are taking in a lot of calories since your metabolism is going haywire. It’s biological activity is 4-5 times less than liothyronine T3 if comparing mg to mg, however, hormonal levels remain more stable and price is also much lower. And there are some other unique advantages, which makes it very competitive with T3 such as appetite suppression, less need of sleep and increasing of physical durability (stamina), so question “which one is better” depends on your goals.Clinical pharmacology book by Goodman says: “Liothyronine is less desirable for chronic replacement therapy due to the requirement for more frequent dosing (plasma t1/2 = 0.75 days), higher cost, and transient elevations of serum T3 concentrations above the normal range. In addition, organs that express the type 2 deiodinase use the locally generated T3 in addition to plasma T3, and hence there is theoretical concern that these organs will not maintain physiological intracellular T3 levels in the absence of plasma T4″Levothyroxine is widely used by bodybuilders and fitness addicts on pre-competition cycle in order to get relief, also used by overweighed people to reduce weight. It increases metabolism and produces general stimulating effects. However, this substance should be used wisely.
Dosage and Administration in fitness and bodybuilding
It is recommended that levothyroxine be taken with an empty stomach approximately half an hour to an hour before meals to maximize its absorption. It is also recommended that the patient take the tablet with one glass of water to ease swallowing as well as to help the tablet dissolve for absorption. Dosages vary according the age groups and the individual condition of the patient, body weight and compliance to the medication and diet. Maximum dosage may reach 400 mcg per day but that is rare. Monitoring of the patients condition and adjustment of the dosage is periodical and necessaryMost people need to be careful to start with a low dosage, about 25 mcgs. per day and increase by about one tab of 25 mcgs every 3-5 days.
On days that you take multiple tabs, divide the tabs evenly across the day (i.e. 100 mcgs. would be 4 doses of 25 mcgs. spread evenly across the day.) Don’t take for more than 5-7 weeks at a time to keep the thyroid functioning properly. After doing a cycle of this drug, make sure you go 4 weeks (better 8 weeks or more) before doing it again as to allow normal thyroid functioning to return.
Cycle 1: classic
Start with 25 mcg / day of T4 and increase by 25.
Do 25 mgs of Metoprolol at the morning (this is beta-blockader, which eliminates heart overload and heartbeating). If heart rate at the afternoon is more than 70 beats/min, take 25 mgs more.
Increase daily dosage of T4 to 150-300 mcg / ED split on 3-4 equal parts. The last one should be consumed before 6 p.m. At high dosages you can increase Metapronol to 100 mg / ED (two times by 50 mg), but in fact metapronol dosage should be found individually keeping heart rate between 60 to 70 beats / min. If heart rate is more than 80 – increase metapronol by 25 mg, if below 60 – decrease by 25 mg.
Watch your blood pressure, it should not be higher than 140/100 mm Hg. Art. Metoprolol reduces blood pressure, too.
Length of treatment should be 4-7 weeks. Do not quit suddenly, smoothly decrease T4 dosage starting 2 weeks before the end of cycle, this will help to restart your thyroid.
In case of diarrhea – use loperamid.
Minimal gap between cycles – 4 weeks
Cycle 2: clenbuterol + L-thyroxin + yohimbine
When taken with clenbuterol, this is the single best fat-burning combination that is available today (with the possible exception of DNP). It also helps to make steroids more effective since it is such a good aid for protein synthesis.
This powerful combo is used in some ready-made fat-burners, however, you can save a lot of money if acquire every of these substances separately. High effectiveness of the cycle is supported by the ability of T4 (or T3) not only increase metabolism and launch fat-burn) but also increase response of the receptors responsible for clenbuterol and yohimbine.
Let’s consider ONE UNIT of this stack like following:
Clenbuterol – 40 mcg +
L-Thyroxine – 25 mcg +
Youhimbine – 5 mg (you can acquire it in sport nutrition shops. If you can’t find it – just disregard)
Recommended cycle:
Day 1-3: 1 unit
Day 4-6: 1,5 units
Day 7-9: 1 unit at the morning and 1 unit afternoon
Day 10-12: 1,5 unit
Day 13-15: 1 unit
Day 16-19: 0,5 units.
Day 20-21: 0, 25 units
Take 30 mins before breakfast with water.
After the cycle make 3 weeks rest before the new one.
In case of fever use 1-2 mg of ketotifin afternoon. For heart protection do beta-blockaders like metapronol 100 mg split on two times/day
Tricky ways of usage
Human body produces 90-110 mcg of l-thyroxine daily. For fat-burn it does not make sense to take just replacement dosages because your thyroid simply decreases production in response and you’ll come to what you started with – the same T3/T4 levels in your body. Thus you have to consume dosages, which are higher than natural. But it’s possible to cheat the gland. If you take 12-25 mcg once every three days it will not affect endogenous T4 production thus making aggregated level higher (!)
I.e. in order to encourage metabolism, optimal dosage is not replacement dosage, but a dosage, which can increase general hormone levels without affecting endogenous thyroid production! Replacement dosage may help only to the people with low thyroid production, but why take more risking toxic effects while you can use much lower dosages?
For instance, normal production is 100 mcg/daily. Patient has 80 mcg/ daily. If he takes 100 mcg / daily he’ll get back to normal, but natural thyroid production will be shut down. However, if he does 25mcg every three days, his body will still produce this very same 80 mcg thus making around 90 mcg in total. Got the idea? Anyway you should discuss this with your GP. For bodybuilding you can use the same scheme – either toy with high dosages or make just minor “tuning” with 25 mcg every three days.
This is safe way of usage, but, of course, effect is incomparable to 150-300 mcg/day. It’s advisable only for relatively small fat-burn.
Medical usage
This medicine is a hormone replacement usually given to patients with thyroid problems, specifically, hypothyroidism. It is also given to people who have goiter or an enlarged thyroid gland.
Precautions and side effects
There are also foods and other substances that can interfere with absorption of thyroxine replacement. Avoid taking calcium and iron supplements within 4 hours of the medication and avoid taking soy products within 3 hours of the medication as these can reduce absorption of the medication. Other substances that reduce absorption are aluminium and magnesium containing antacids, simethicone or sucralfate, Cholestyramine, colestipol, Kayexalate. Other substances cause other adverse effects that may be severe. Ketamine may cause hypertension and tachycardia and Tricyclic and tetracyclic antidepressants increase its toxicity.On the other hand Lithium causes hyperthyroidism by affecting iodine metabolism of the thyroid itself and thus inhibits Synthetic levothyroxine as well. Synthetic levothyroxine may have adverse side effects like: palpitations, nervousness, headache, difficulty sleeping, insomnia, swelling of the legs and ankles, weight loss and/or increased appetite. Allergies to the medicine are unlikely, but if the patient develops a severe reaction to this drug such as difficulty breathing, shortness of breath or swelling of the face and tongue it is imperative that the patient immediately seek medical attention. Acute overdose may cause fever, hypoglycemia, heart failure, coma and unrecognized adrenal insufficiency. Acute massive overdose may be life-threatening; treatment should be symptomatic and supportive. Massive overdose may be a require beta-blockers for increased sympathomimetic activity. The side effects of overdosing appear 6 hours to 11 days after ingestion.
Prolonged use of high dosages in theory may lead to serious problems with thyroid and suppression of endogenous hormone production (fortunately, studies shows only 20% down after 3 weeks of usage). However, when used properly at recommended dosages, thyroid function restores after 3-4 weeks
Levothyroxin has adrenalin-like effects including increased heart rate and nervousness, which could be avoided by using beta-blockaders
Advantages
- Extremely powerful fat-burner in combination with clenbuterol
- Increased stamina
- Lower sides comparing to T3
- You can buy Levothyroxine T4 here
Where can I buy steroids with VISA
September 13th, 2012VISA and MasterCard STRICTLY PROHIBITS selling steroids with credit card, full stop. Actually this ban is for all controlled substances from DEA Schedule list. They have such policy since 2007 due to US government pressure. Personally, I used to know a couple of sites who overruled this even after the ban by cheating VISA somehow, but they don’t sustain for a long.
So if you see any “steroid” site, who offers you credit card as a payment method – know that this is a scam with 99.99% guarantee (exeptions are so rare and their lifetime is so short that you have virtually no chance to find one). For instance, steroid.com and it’s affiliates sells cheap vitamins / food supplements under steroid-like brand names and substantial prices. Of course, they are not absolutely useless, but you can buy the same vitamins in the nearby pharmacy twenty times cheaper. So don’t let to fool you,and don’t buy such tricks as “legal steroids” or “buy steroids with VISA”. And check every supplier at review sites.
Long R3 IGF-1 (Insulin-like Growth Factor)
August 25th, 2012IGF-1 is the abbreviation for Insulin-Like Growth Factor 1. This is a naturally occurred long-chain polypeptide protein hormone and not a dangerous steroid. IGF-1 has molecular structure, which is quite similar to insulin. IGF-1 plays a vital role in childhood growth, especially bones and stimulates anabolic effects (muscle growth) in adults. IGF-1 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the body
Long R3 IGF-1 is a more potent version of IGF-1. It’s chemically altered to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min.
There are 70 inter-connected amino acids that make up a single chain of IGF-1. This hormone is produced when the liver is stimulated by human growth hormone (HGH). When levels of HGH rise in the blood, the liver responds by producing more IGF-1. These higher “bursts” spur growth and regeneration by the body’s cells, especially in muscle cells. Increases in IGF-1 levels have shown positive effects on increases in muscle strength, size, and efficiency. When you do not have enough IGF-1 in your body, whether caused by disease, malnutrition or a hormone imbalance, your growth can be stunted.
The primary purpose of IGF-1 is to stimulate cell growth. Every cell in the human body can be affected by IGF-1, but cells in muscle, cartilage, bone, liver, kidney, skin tissue, lungs, and nerves tend to be most positively affected.
Products which increase IGF-1 can help improve muscularity and healing and recovery times. IGF-1 can also stimulate a decrease in body fat, an increase in lean muscle mass, improved skin tone and restful sleep. IGF-1 has also been documented to increase the rate and extent of muscle repair after injuries or strains. Not only do muscles recover more quickly, they also tend to return stronger and healthier than ever when levels of IGF-1 in the bloodstream are at their highest.
IGF-1 also has a positive affect in the aging process. It can prevent age-related degeneration of muscles, skin tissue and bones. Because IGF-1 levels tend to level off and fall rapidly when the liver is not stimulated by HGH production, these benefits are greatest when consistently high HGH levels are maintained.
Combined with other supplements and monitored responsibly, IGF-1 can be beneficial for those individuals who suffer from stunted growth or growth hormone deficiencies as well as those individuals who strive to be in the best physical shape possible. Athletes, bodybuilders and physical competitors around the world are learning all about the benefits of IGF-1 and implementing the growth hormone into their daily regimented workouts. Whether you are an athlete yourself, or you prefer to workout more than a few times a week, IGF-1 can be beneficial for you. Even if you aren’t an athlete at all, but are looking to get as healthy and fit as possible for your own reasons, IGF-1 can be beneficial for you.
IGF-1 dosages and length of cycle
IGF-1 novices will be able to use a smaller dose than a more advanced user. For your first IGF-1 cycle, you need to remember that less is more, meaning that you don’t have to use a lot to get great results. This is not like testosterone where you need big doses for big muscles. For your first or second cycle with IGF-1, you will use 50mcg per injection day, 3 days per week (or 20-25 mcg daily), and split into two daily injections. For LONG R3 IGF-1 you can inject less frequent. for advanced users dosages may grow but never exceed 120 mcg daily.
The same is true for the length of cycle. IGF-1 effectiveness falls rapidly after prolonged use. Some users report 40 days, some 60 days, but our advice is to limit IGF-1 cycle for 4-5 weeks to get maximum effect then take rest. Some advanced users may do 50 days but only if they know what they’re doing. Too much IGF-1 will result in deregulation of IGF-1 receptors on the surface of muscle cells. This will jeopardize any gains from the injected IGF-1 since very little receptors means very little response! Time gap between cycles should be 20-40 days.
IGF-1 is also best taken either subcutaneously (preferably) or IM, having more direct effects on the body when injected. It’s also recommended to be taken during the morning/evening only (novice) or after work out only (novice) or morning/evening plus after weight training sessions (advanced user). So advanced user makes from two to four injections daily.
IGF-1 usage
Assuming that we use the lyophilized form (dry powder) of Long R3 IGF-1, equivalent to a 1000 mcg vial, it is best prepared by using 1ml or 2ml of acetic acid. Let the acetic acid seep into the vile after removing the vacuum from the container. Then, let the mixture in the vial sit for a while. Put it in the fridge where the IGF-1 mixture can dissolve without accidentally knocking the vial or shaking its contents. Then afterwards, it’s all about diluting your Long R3 IGF-1 in NaCl or bacteriostatic water before intra-muscular or subcutaneous entry.
In most cases you have 1mg (1000mcg) bottle of substance, with 1 ml of pre-made acid. Since we want to use 25mcg for our injection, you need to use an insulin syringe (29 gauge 50 IU for easier measuring) and withdraw to the 2.5 tick mark on the syringe. Yes, that is a very, very small amount to withdraw which is why we recommend the 1/2cc or even 30 IU syringes. Now using acetic acid can be very painful, and it is almost impossible to inject such a small amount so you will now use bacteriostatic water or NaCL water to add more volume to the syringe. This will also help reduce the pain of the acid injection. After you withdraw your small 2.5 IU on the slin pin, just finish filling the syringe with the water.
But what to do if IGF-1 comes in powder and there’s no acid supplied (generic brands)?
That’s not easy subject to answer 
If you dissolve in bacteriostatic water lifetime will be too short. Some users claim it’s just 2-3 days under +4C, so in this case you have to dissolve TOO small dosages, which is very difficult. However, in special acid solution it lives up to 4 weeks. Put 4 ml solution into 1 mg IGF-1. 1 mg = 1000mcg
How to prepare acid solution? You need bacteriostatic water, acetic acid, syringe 10 ml, and filter 0.22 mm or better 0.11mm
Take 1 ml 99% acetic acid then 7ml sterile water, shake well then leak out 7 ml out of total 8ml. Add 7ml of water AGAIN, so finally we receive 1,5% acetic acid solution.
Preferably put filter onto the syringe and put 4 ml of solution into 1mg IGF1 vial.
Insulin syringe has 40 IU for 1 ml (when measuring insulin and IGF). Thus 4 ml of solution contains 250 mcg per ml.
1000mcg/4mL: 31 mcg per 5 IU
40 IU = 250 mcg
20 IU = 125 mcg
10 IU = 62,5 mcg
So, if your dosage is 30 mcg utilize 5 IU, if dosage is 25 mcg, utilize ~4.5 IU
It’s not advisable to freeze liquid but if there’s no other way – do it no more than 1 time
Stacking IGF-1
The IGF-1 that’s produced from the use of fast acting Nandrolone or Trenbolone is nothing significant when you compare to the amount that’s contained in a single 10mcg Long R3 injection. Having said that, it’s safe to inject exogenous IGF-1 while taking either one of these compounds.
IGF-1 and Human Growth Hormone?
Long R3 IGF-1 can directly stimulate muscle growth when compared to human growth hormone (HGH). This is because HGH indirectly results in growth and repair by first inducing IGF-1 release in the liver. If you don’t have to worry about IGF-1 release in the liver (because your directly injecting the IGF-1), new growth will be optimized.
Usage of IGF-1 brings more faster results than HGH because HGH acts indirectly and process is slower.
If stacking with HGH after workout you can do for example like this: 5 IU HGH then 50 mcg IGF after 20 minutes (or smaller dosages if you make more frequent injections).
Is there a benefit to using both of these substances together?
“Many research studies have shown that GH and IGF-1 act synergistically to augment the effect of either hormone taken individually. So, the greatest results will take place when effective dosages of both hormones are injected. Usually 10-20mcg of IGF-1 (post workout) and 4-8 IU HGH EOD (with breakfast and at 1 p.m.) is the ideal stack for optimal results and minimal side effects.
Medical usage
Tissue build up is one of the main features of IGF-1, so I’d say it’s of greater value. IGF-1 can genetically change muscular and cellular counts within the body; it can also enhance the body’s ability to regenerate damaged tissue. In fact, IGF-1 is now under intensive research for its potential to repair tissue in burn patients, and for its regenerative effects on AIDS patients suffering from muscular wasting. Immediate effects are, of course, impossible to observe since it takes a respectable amount of time to see any visible changes in muscular repair.
There’s no known lethal risk of administering IGF-1 to diabetic patients. In fact, IGF-1 can reduce the body’s need for insulin, and according to one short study, it can reduce insulin dependence of the body by as high as 45%. This may bring very promising results if we are allowed to study this matter further. If anyone experiences any uncomfortable side effects, stop it’s usage and see if the side effect disappear.
Side effects of IGF-1
IGF-1 is commonly known to cause feelings of fatigue. Some people feel very tired quickly when using this compound. It can, however, be looked at in a more positive light since more sleep means better growth. Other side effects include muscular stiffness, headaches, occasional nausea, and some also claim that it’s sometimes responsible for hypoglycemia or low blood sugar.
You can purchase Long R3 IGF-1 (Insulin-like Growth Factor) here.
Cytomel (liothyronine sodium, triiodtironine, T3)
June 17th, 2012There are three related thyroid hormones responsible for metabolism – tricodide-thyronine (L-T3), L-thyroxine (L-T4) and thyrotrophic hormone responsible for launching T4 production. Most of natural T3 is not produced directly by your thyroid gland, but rather is converted from the T4 thyroid hormone. Cytomel is a synthetically manufactured liothyronine sodium (T3) which resembles the natural T3 hormone .
Cytomel (Liothyronine Sodium, L-T3) has proven to be 4-5 times more biologically active and to take effect more quickly than levothyroxine T4. T3 has a faster onset of action as well as a shorter biological half-life, probably due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
In school medicine Cytomel (Liothyronine Sodium) is used to treat thyroid insufficiency (hypothyroidism). Among other secondary symptoms are obesity, metabolic disorders, and fatigue.
T3 is not dangerous – it will temporarily shut down your natural thyroid function which can produce a lag after supplementation unless you taper correctly – it will eat muscle though, unless you are taking anavar , winny or primo while taking it. It is a great stack with clen.
Cytomel T3 in bodybuilding and fitness
Natural T3 is a regulator of the oxidative metabolism in cell’s mitochondria. Thus higher T3 level means an increase in overall metabolic activity – your body spends more energy and burns more fat because of this. In low dosages, especially if taken along with steroids, it can even serve for certain muscle growth – due to increased metabolism. However, in high dosages it shifts towards catabolism and burns fat along with muscles.
Bodybuilders take advantage of these characteristics and stimulate their metabolism by taking Cytomel (Liothyronine Sodium), which causes a faster conversion of carbohydrates, proteins, and fats. Bodybuilders, of course, are especially interested in an increased lipolysis, which means increased fat burning. Competing body builders, in particular, use Cytomel (Liothyronine Sodium) during the weeks before a championship since it helps to maintain an extremely low fat content, without necessitating a hunger diet. Athletes who use low dosages of Cytomel (Liothyronine Sodium) report that by the simultaneous intake of steroids, the steroids become more effective, most likely as the result of the faster conversion of protein.
Cytomel (Liothyronine Sodium), is a good replacement for proviron on pre-competition cycles, especally for females. The over stimulated thyroid burns calories like a blast furnace. Those who combine T3 and clenbuterol receive synergetic effect especially because of better regulation of beta 2 receptors in fat tissue, which clen tends to deregulate. As a result these two compounds burn an enormous amount of fat.
Proper high-protein diet is important, taking non-bulking steroids like winstrol or primo is desirable while taking T3, otherwise athlete may lose too much muscle, especially while dieting.
A good stack for max results during minimal time might be Insulin, T3, AAS like primo or winstrol and HGH.
Female usage
Cytomel (Liothyronine Sodium) is also popular among female body builders. Since women generally have slower metabolisms than men, it is extremely difficult for them to obtain the right form for a competition given present standards. A drastic reduction of food and calories below the 1000 calorie/day mark can often be avoided by taking Cytomel (Liothyronine Sodium). Women, no doubt, are more prone to side effects than men but usually get along well with 50 mcg/day. A short-term intake of Cytomel (Liothyronine Sodium) in a reasonable dosage is certainly healthier than an extreme hunger diet.
Cytomel Side Effects
T3 also increases growth hormone (HGH) production, which is not bad by itself but may lead to even bigger muscle burn along with fat because HGH is also a strongly lipolytic compound, and this is another mechanism by which T3 may exert its effects. In case of T3+HGH standalone stack this may be a problem, but using some anabolic steroids is going to help with this.
Possible side effects are: trembling of hands, nausea, headaches, high perspiration, and increased heartbeat. These negative side effects can often be eliminated by temporarily reducing the daily dosage.
Dosage and Usage of Cytomel T3
As for the dosage, one should be very careful since Cytomel (Liothyronine Sodium) is a very strong and highly effective thyroid hormone. It is extremely important that one begins with a low dosage, increasing it slowly and evenly over the course of several days. Most athletes begin by taking one 25-mcg tablet per day and increasing this dosage every three to four days by one additional tablet. A dose higher than 100-mcg/ day is not necessary and not advisable. It is not recommended that the daily dose be taken all at once but broken down into three smaller individual doses so that they become more effective.
It is also important that Cytomel (Liothyronine Sodium) not be taken for more than six or max eight weeks. At least two months of abstinence from the drug needs to follow. Those who take high dosages of Cytomel (Liothyronine Sodium) over a long period of time are at risk of developing a chronic thyroid insufficiency. As a consequence, the athlete might be forced to take thyroid medication for the rest of his life.
There are some opinions that using cytomel is absolutely safe for a long time and it’s easy to restore thyroid production afterwards.
-I quote – The horror stories of people on permanent thyroid replacement just aren’t true. …people recovering their thyroid hormone relatively quickly (within months, at most) after going off of several YEARS (!) of thyroid replacement therapy. …we can safely spend an athletic career using Cytomel 9-10 months out of the year, and just taking those few months off to normalize ourselves. Is this aggressive? Yes. Is this unsafe? NO. – end of quote-
Maybe that’s true. But maybe not. So in this 50/50 situation we would advice to stay on “cowardly” side and use T3 with all precautions until the opposite will be scientifically proven.
It is also important that the dosage is reduced slowly and evenly by taking fewer tablets and not be ended abruptly.
Those who plan to take Cytomel (Liothyronine Sodium) should first consult a physician in order to be sure that no thyroid hyperfunction exists. If you have never used T3 before, it is suggested that you lessen your constant time and increase your ramp up period to determine your reaction to t3 before heavy use.
Some people wait until your thyroid shuts down in a cutting cycle (as it will when on DNP , heavy ECA , clen – anything that raises the body temp high), however, it should just be part of the whole cycle, not just replacement therapy on the end when you are on low endogenous T3.
When it’s used in a bulking cycle to help absorb all the protein – never go over 50mcg / ED, better even do 25mcg / ED. For cutting cycles dosage might be higher.
T4 may also be used to good effect with the same way but of course the dosages are different – the ratio of t4:t3 is about 4:1 or 4.5:1 so 100mcg of t3=about 400-450mcg of t4
Common approach is to increase T3 from zero to full dosage during the fists 4-7 days and then decrease at the same rate at the end. However, thyroid shuts down rather quickly, so, in order to restart the gland after the cycle it’s better to lengthen “decrease” period, for instance you spend 5% of time of increasing dosage then 40-50% of time on max throttle then remaining time on slow and even decrease of the dosage over the weeks. With this you may come to the end of cycle with warming up thyroid and smoothly finish using of tabs.
For instance, here’s an example of 3 weeks cycle and .25 tabs
4 days= 1, 1.5, 2, 3 tabs
7 days= 4 tabs
10 days = 3, 3, 2, 2, 2, 1, 1, 1, .5, .5 tabs
Testogel (Androgel) [Testosterone sachets]
June 14th, 2012Testogel (androgel, testosterone sachets) by Bayer Schering comes in boxes containing 10 or 30 sachets 5 g each (50 mg of testosterone inside), totally 500-1500 mg of active substance.
Testogel is used for treatment of low testosterone levels in men in easy and convenient way by replacing natural hormone. Such decease is called hypogonadism and it may have a serious negative impact on the quality of men’s life (especially elderly men) and are commonly associated with a decrease in libido, lean body mass and bone density, as well as an increase in visceral fat, and disturbances in well-being and mood. Transdermal 1% hydroalcoholic Testogel restores testosterone levels to normal range and had a statistically proven, significant positive effect on lean body mass and body composition.
Dosage and usage
Cutaneous use only. Testogel contains native testosterone in a clear and colorless formulation which is absorbed by the skin within a few minutes after the morning application to the upper arms, shoulders and abdomen, without leaving any residue. The testosterone passes from the gel through the skin and follows into the bloodstream at a steady rate. The recommended dose is 5 g of gel (i.e. 50 mg of testosterone) applied once daily approximately the same time to maintain steady level. The serum testosterone concentration remains very reliably within the normal range for 24 hours after application.
Even if toying with higher dosages, you should not aply more than 10 g per day. “More” is not always “better”. The adjustment should be achieved by 2.5 g of gel steps. The gel should be administered by the patient himself, onto clean, dry, healthy skin. Allow drying for at least 3–5 minutes before dressing. Do not shower for at least six hours after applying Testogel to make it fully utilized by the body.
Testogel helps to control the symptoms of your condition, but does not cure it. Therefore, you must use Testogel every day throughout the life. In general, testosterone-replacement therapy is indicated for all men over 40, starting from the small dosage and increasing with the age. However, one should do it only in accordance with doctor’s advice basing on proper tests. Some people may have sufficient endogenous testosterone levels for longer period of time, some others may still want to have a child, so use any medications including Testogel wisely.
Stacking
Hey, this is not for bodybuilding. No stacking, standalone usage is just fine for testosterone-replacement therapy.
Side effect and PCT
This is testosterone and androgen-related side effects might be an issue in theory. However, due to weak action most of these effects are possible to neglect. However, prolonged use of testosterone containing products may result in aromatization process and thus estrogen-related sides such as growing breast and conversion to DHT reslting in destroying of hair follicles. Both of these processes are coming even naturally, that’s why many elderly men lost their hair and have “bitchy tits” without using any testosterone. Possible answer to that might be using low-dosages of propecia (finasteride) and tamoxifen citrate.
It may lead to increasing hematocrit levels, which is not bad thing for stamina but dangerous because of increased blood viscosity, especially for elderly men.
Another possible and very important side is decreased sperm count, which may affect fertility.
There are also some others, do not get frightened, this is just minor possibility, most of people do not experience anything of it.
Possible local side effects: erythema, acne, dry skin.
Possible systemic side effects: prostatic disorders, gynecomastia, mastalgia, dizziness, hyper- and paresthesia, amnesia, mood disorders, hypertension, diarrhea, alopecia, polycythemia, increased serum lipids.
Other known adverse drug reactions of treatments containing testosterone are: prostatic changes and progression of sub-clinical prostatic cancer, urinary obstruction, pruritus, arterial vasodilatation, nausea, cholestatic jaundice, changes in liver function tests, increased libido, nervousness, myalgia and, during high dose prolonged treatment, electrolyte changes, oligospermia and priapism.
Doping control
Athletes should note that the active substance, testosterone, may produce a positive reaction in antidoping tests.
Indications
Testosterone treatment for confirmed male hypogonadism.
Not advisable to use in the sport, especially bodybuilding because it’s too weak component, better use injectable testosterones like sustanon with more effect for the same money.
Contraindications
Cases of known or suspected cancer of the prostate or breast, known hypersensitivity to testosterone or to any other constituent of the gel, skin conditions prohibiting the topical application of medication.
Planning to have a children (usage must be ceased some months before it and proper PCT like clomiphene citrate used)
Testogel must not be used by children under the age of 18 years because it may destroy natural hormone production and woman due to high risk of androgen related side effects, especially masculinisation (virilization).
Special warnings and precautions
Exclusion of risk of pre-existing prostatic cancer, monitoring of the prostate gland and breast. Regular monitoring of serum calcium concentrations is recommended in cancer patients at risk of hypercalcemia (and associated hypercalciuria), due to bone metastases. Testogel may cause edema with or without congestive cardiac failure in patients suffering from severe cardiac, hepatic or renal insufficiency. In this case, treatment must be stopped immediately. Testogel should be used with caution in patients with ischemic heart disease. Testosterone may cause a rise in blood pressure and should be used with caution in patients with hypertension. Beside laboratory tests of the testosterone concentrations in patients on long-term androgen treatment the following laboratory parameters should be checked periodically: hemoglobin, hematocrit (to detect polycythemia), liver function tests. Testogel should be used with caution in patients with epilepsy and migraine as these conditions may be aggravated.
Testogel may quicken the growth of existing prostatic tumours and benign prostatic hyperplasia (enlargement of the prostate gland). It may also increase the risk of breast cancer in males. Before treatment, your doctor should conduct tests to check that you do not have existing prostate or breast cancer.
If you use Testogel over long periods of time, you may develop an abnormal increase in the number of red blood cells in the blood (polycythaemia) and thus increase blood viscosity. Take aspirin to treat this side effect, stronger oral anticoagulants are not needed unless prescribed by a doctor.
Testogel is not indicated for use in children and has not been evaluated clinically in males under 18 years of age. Pregnant women must avoid any contact with Testogel application sites. This product may have adverse virilizing effects on the fetus. Testogel is no treatment for male impotence or sterility. For further details refer to the package insert or contact your local Bayer HealthCare Pharmaceuticals organization.
You should leave a gap of 6 hours between applying Testogel and having intimate physical contact to prevent passing of the testosterone to the female. You should also wear clothing such as a T-shirt to cover the gel application area and/or have a shower or bath beforehand. You should also follow these precautions before coming into close contact with children. If a woman or child does come into contact with Testogel, thoroughly wash the area of skin exposed to the gel with soap and water.
Female usage of testogel
Not advisable due to the risk of masculinisation (virilization).
Storage
Keep Testogel in a cool dry place where the temperature stays below 25°C. Do not store it or any other medicine in the bathroom, near a sink, or on a window-sill. Do not leave it in the car. Heat and dampness can destroy some medicines.
Pharmacologically inactive ingredients
Carbomer 980, isopropyl myristate, ethanol 96%, sodium hydroxide, purified water.
Nebido [Testosterone undecanoate injectable]
June 12th, 2012Low testosterone levels should be confirmed by two separate blood testosterone measurements and include following symptoms, which Nebido intends to cure: impotence, infertility, low sex drive, tiredness, depressive moods, bone loss caused by low hormone levels. In general, mild testosterone replacement therapy is advisable for men over 40, for men over 65 it’s vitally important since endogenous production becomes critically low.
Testosterone Undecanoate may also be used for other conditions as determined by your doctor.
Dosage and usage – medical and bodybuilding
According to the manufacturer, common Nebido dosage is single 1000 mg injection made every 10-14 weeks, i.e. ~4 times a year. Unfortunately, many physicians follow that claim and schedule. I do not pretend to be smarter than these doctors, however, there are no independent studies, proven this. Furthermore, bodybuilding is completely different story. Taking into consideration that half-life time of testosterone undecanoate is 21 day, in bodybuilding monthly, bi-weekly (or even weekly?) injections are advisable to maintain testosterone level stable. I’m not saying that it’s absolutely necessary to inject bi-weekly, but in general it’s much better than taking it once every 6 or even 12 weeks as stated by manufacturer. Disregarding of what ester you use – frequent injections is the best way to keep your test levels stable. Longer half life just means that you can do it less frequent comparing, for instance, to sustanon (3 shots / week) or enanthate (2 shots / week). Dosages in bodybuilding should be much higher than medical dosages, something like 1000 mg monthly, and this is one more point to use more frequent injections than stated by manufacturer. We do not advice higher dosages of nebido, if you need more effect, just use different testosterone forms.
But if this is a medical issue, take Testosterone Undecanoate only as directed. Discuss the point above with your GP, but final decision is up to him. Do not take more of it and do not take it more often than your doctor prescribed. To do so may increase the chance of side effects.
Nebido is intended strictly for intramuscular injection (preferably into the buttock). Special care should be taken to avoid injection into a blood vessel The testosterone is gradually released all the time from the reservoir into the bloodstream and remains effective for a very long time.
Stacking
In bodybuilding stack just as regular testosterone undecanoate (andriol / restandol) – with other safe dugs like anavar, primobolan, etc. Stacking with stronger drugs like deca will just negate it’s very-low-side-effects advantage.
Benefits of using Nebido
Testosterone replacement therapy can produce profound physical and/or mental changes in patients with low testosterone. The benefits of testosterone replacement on physical and sexual function, energy levels, fat and muscle mass, blood lipids and bone density in men with low testosterone are well accepted. Thus, one should observe following effects with Nebido:
Increased sexual interest generally appears after 3 weeks and levels off at 6 weeks
Increases in erections and sexual satisfaction occur within 6 months
Improvements in quality of life are clear within 3-4 weeks and continue for some time
Improvement in depression or mood is noted after 3-6 weeks and reaches a maximum after 18-30 weeks
Beneficial effects on blood lipids appear after 4 weeks and reach a maximum after 6-12 months
Improvements in blood glucose levels become evident after 3-12 months
Changes in body composition and muscle strength occur within 12-16 weeks and stabilize at 6-12 months
Improvements in bone density show after 6 months and continue for at least 3 years
Minor changes in prostate size and a slight increase in the level of prostate-specific antigen occur with treatment, leveling off after 12 months. Any further increases may be related to normal aging rather than testosterone treatment.
Source: Onset of effects of testosterone treatment and time span until maximum effects are achieved. Saad F, Aversa A, Isidori AM, et al. Eur J Endocrinol 2011;165(5):675-685.
Detection time
Nebido might lead to positive results in drug tests. Detection time is longer comparing to oral forms, unfortunately, there is no sufficient information on this subject.
Nebido (testosterone undecanoate) side effects and PCT
Treatment with high doses of testosterone preparations commonly stops or reduces sperm production, although this returns to normal after treatment ceases. High-dosed or long-term administration of testosterone occasionally increases the occurrences of water retention.
Nebido is testosterone ether and androgen-related side effects might be an issue in theory. However, due to mild action these effects are so weak that Nebido could be considered as very safe drug unless the dosage is too high.
However, if you observe any estrogen-related side effects such as breast growth or female-pattern fat deposits start using tamoxifen. If you are toying with high dosages clomiphen might be necessary after the cycle.
If you are diabetic, it may be necessary to adjust your insulin.
Female usage
Medical usage of Nebido is contraindicated for women and certainly must not be used in pregnant or breast-feeding women. Some exclusions are transsexual females.
Unfortunately, we cannot provide any reliable information on this subject in bodybuilding so far. Oral testosterone undecanoate is the only form of testosterone, which could be used by females without serious side effects at daily dosage of 120-240 mg, it well combines with anavar (oxandrolone) and, sometimes, primobolan. However, with injectable form of testosterone undecanoate situation is different because more testosterone is delivered into the system (and less wasted) comparing to oral form, so on our opinion, if used by females dosage should be lower than with andriol.
Contraindications
Nebido is not intended for use in women. Nebido is not for use in children and adolescents.
Do not use Nebido:
if you have ever had androgen-dependent cancer or suspected cancer of the prostate or of the breast
if you have or have ever had a liver tumour
Prior to testosterone initiation, all patients must undergo a detailed examination in order to exclude a risk of pre-existing prostatic cancer. Careful and regular monitoring of the prostate gland and breast must be performed (the same is true for any testosterone treatment).
Tell your doctor if you have or have ever had: epilepsy, heart, kidney or liver problems, migraine, temporary interruptions in your breathing during sleep (apnoea), as these may get worse;
cancer, as the level of calcium in your blood may need to be tested regularly;
blood clotting problems;
If you are suffering from severe heart, liver or kidney disease, treatment with Nebido may cause severe complications in the form of water retention in your body sometimes accompanied by (congestive) heart failure.
Nebido Storage
Keep out of the reach of children.
Store away from heat and direct light at room temperature.
Keep the medicine from freezing.
Do not keep outdated medicine or medicine no longer needed.