EPO - Erythropoietin generic (Kina)
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Erythropoietin (EPO) is a major hormone involved in the regulation of red blood cell production. The isolation and production of this hormone is very beneficial for medical purposes. This hormone can cure various forms of anemia, effectively stimulating production of red blood cells. The effectiveness of EPO quickly replaced the previous less effective types of drugs, for example, Anadrol.
Recombinant EPO is a purified single chain of a polypeptide hormone containing 165 amino-acids. The drug is made from animal cells, into which the human erythropoietin gene is introduced. The biological activity of recombinant EPO does not differ from human normal erythropoietin.
Erythropoietin in sports
Many athletes use EPO because it is responsible for the production of erythrocytes. Probably everyone heard of the so-called “blood doping”. This procedure involves removing blood in order to store it and then replace it. Athletes add stored blood to the body right before the competition (by this time restores the lost amount of blood). Therefore, they have a much larger number of red blood cells, thus getting noticeable increase in endurance.
Epo side effects
However, the procedure involving blood doping is very risky, since you can get infection due to improper blood storing. Some of the risks are mitigated by EPO, nevertheless, you should be very careful with dosing since increased red blood cell counts can be very dangerous. If erythropoietin is used incorrectly, the concentration of erythrocytes can reach extreme level, which leads to high blood viscosity. As a result, heart attack or stroke may happen.
Due to increase in the number of red blood cells, blood pressure can rise, followed by headaches. Moreover, symptoms similar to flu may appear. Irritation at the spot of injection is also possible. In case of strong manifestation of sides, you should stop using the drug.
Erythropoietin can be administered subcutaneously or intravenously. Each of these routes of administration has different effects. During intravenous administration, the peak levels is reached very quickly. The half-life is also short, about 4-5 hours. When injected subcutaneously, the hormone levels raise to a maximum of 12 to 18 hours. The half-life is also much longer, about a day. For clinical use starting doses range from 15 to 50 units per kilogram of body weight, three times a week. At this dosage, an athlete weighing 70 kg will receive a maximum of 4000 units in one injection. You should stop using Erythropoietin several days or a week before the competition in order to pass through doping control.
In order to avoid blood clotting, take aspirin (after meal) and avoid dehydration