How to use :sustanon250:?

List of recomendations of using Sustanon 250:

• Cycle length – 6 weeks (for longer cycles use HCG – Pregnyl)
• Normally you have to inject once a week. But if you are dissatisfied with the results, try to split it on two shots, if possible.
• start anti-estrogen (tamoxifen citrate) from week 2, 10mg/ED and stop 4 weeks after it (you can substitute tamoxifen with clomid on the week 3 after the cycle).
• Start using natural testosterone boosters like clomiphene citrate (clomid) 3 weeks after the cycle.
• For maximum efficiency use proteins and special diet
• For better results Try to stack it, let’s say with deca, 400 mg/week

Sustanon description

Sustanon (também conhecido como Omnadren) is a mixture of different testosterone esters. First developed and introduced by Organon as a means of hormone replacement therapy when there is insufficient secretion of endogenous testosterone. Currently, almost all of the mixture of testosterone  esters equated to Sustanon, a large number of drugs manufactured clandestinely.

Sustanon contains 4 forms of testosterone:

• 30mg Testosterone Propionate
• 60mg Testosterone Phenylpropionate
• 60mg Testosterone Isocaproate
• 100mg Testosterone Decanoate

Each form of testosterone, which is part of Sustanon has a different rate of absorption, which allows to maintain constant high level of anabolic hormones in the blood during the month. There is no need to perform frequent injections, for medical purposes Sustanon is injected only 1 time in three weeks. Some believe that Sustanon is a combined course in one bottle, but it is not true. Because every component of the drug converted in the body only in testosterone.

The peak of sustanon popularity was on 80es and 90es of the last century, this time there were written many articles about the benefits of the drug . However, remember that Sustanon is not designed as a drug to increase muscle mass, but its main advantage is the ease of use. Sustanon has a great value compared to separate esters of testosterone ( in equivalent amounts), whereas anabolic properties are not different from the isolated forms of testosterone , which makes its use in bodybuilding is not quite justified.

Sustanon effects

Sustanon works just like any other form of testosterone. This means that the main effects of sustanon are:

• Increased muscle mass ( an average of 6 kg per month)
• Anti catabolic effect
• Increased appetite
• Increased blood – increasing the number of red blood cells provides a better oxygen transport, due to which increases endurance
• Increased libido (at the time of taking sustanon)

!!!  Doping control: Time of detection of the drug is up to 3 months.

Sustanon – side effects

Like any other form of testosterone , Sustanon is converted into estrogens. For this reason, Sustanon cause side effects such as gynecomastia , edema, deposition of fat on the female type and the oppression of its own testosterone production. These side effects can be prevented, if applied antiestrogen – tamoxifen (nolvadex) or Clomiphene citrate (clomid).

As a result of reduced production of endogenous testosterone may develop a serious adverse effect of Sustanon is testicular atrophy. This side effect can be prevented if you do not do a course of Sustanon longer than 8 weeks and take antiestrogen . For longer courses require the use HCG (pregnyl, gonadotropin).

In the body, testosterone is converted into dihydrotestosterone, which causes the following side effects: hypertrophy of the prostate, baldness, acne and others. This so -called androgenic side effects of Sustanon.

Also, athletes often report fever and flu-like condition during the course of  Sustanon. Like most steroids, Soest increases the level of harmful cholesterol in the blood (prophylacts reception omega-3 throughout the course).

Sustanon stacks (courses with sustanon)

Sustanon can be combined with such drugs as:

• Nandolone decanoate (deca durabolin) – for a set of muscle mass.
• Winstrol – drying and relief.

The combination reduces the incidence of side effects and improve the effectiveness of the course.

Sustanon 250

In this article I want to talk about the drug called Sustanon – 250, which involves a lot of myths in the environment of ” chemistry “, so that the title of this article was not invented by accident. Those who uses it in his steroid courses, divided into two groups, those who were delighted with the results obtained and those who believe that this drug is a waste of money (plus intermediate forms of these polar opinions ). What exactly is a contradiction of opinions? Let’s try to understand.

History of Sustanon

Let us turn to the history of creation and production of anabolic androgenic steroids and drugs.

Androgens

History of androgen drugs begins with the experience of biologists and physicians to study the work of the endocrine glands. It happened in the early 20 th century, and the time it is known that if there were just a “barbarian” from the standpoint of modern rules of experimental method. Studying the function of sexual glands was carried out on animals in this way : experimental animal castrated and then recorded the changes in physiological processes , metabolism and behavior of the animal , then the same animal sewed his ” farm “(or donor ) in place or beginning to make him injections with an extract of sexual glands of animals and observed changes . This is a classic example of a scientific experiment on a guinea, also called Awawadesign, where in successive experiments measured the same parameters (eg, body weight, blood composition , etc. ) in the experimental , changing what is called independent variable – in this case the level of sexual hormones in the blood. Ie first examined healthy animal , and then it deforms, and again examined , treated and then examined again – in general, savagery, but began the modern science.

In general , as a result of these experiments have clarified the effects of sex hormones on the body , and many other interesting data. It was found that the male sex hormone influences not only the expression of secondary sexual characteristics and the development of sexual organs, but also has anabolic effects. Then the idea arose of testosterone to treat people suffering from a lack of body mass (various forms of malnutrition , starvation , etc.) , and of course the people who , due to various diseases or as a result , injuries testicles either absent or poorly functioning . Remember that testosterone in men is produced mainly in the testes ( small amounts of testosterone and other androgens are produced more adrenal cortex ).

The first mass trials of testosterone preparations were carried out on the liberation of the German concentration camps after World War II . Exhausted people are better gained weight and went to the amendment , if they stabbed testosterone.

Anabolic steroid

But testosterone but has also a strong anabolic androgenic effect – increases the body hair on the body, strengthens the libido , in addition , were found side effects of testosterone therapy – that draws the mouth among the ” chemists ” acne , and the suppression of endogenous testosterone production by the mechanism of feedback , Delay of water and salts in the body, gynecomastia (testosterone can be converted into estrogen – Female sex hormone , which inter alia facilitates the development of mammary glands ) , alopecia (interestingly, from testosterone throughout the body hair grow thicker, but at their head becomes smaller – run the hair from her head to the body 🙂 ), etc.

Then the doctors wanted to invent a drug on testosterone, that would have its anabolic qualities, but was the least androgenic – so there were various synthetic testosterone derivatives , which are called anabolic steroids. Scientists have created on the basis of testosterone , altering its formula , a lot of different drugs – nandrolone , methandrostenolone , boldenone and other anabolic steroids were used for the correction of underweight and under different conditions patologichekih be enhanced anabolic processes.

However, it soon became clear that the invention products have as little as androgen , respectively , and less anabolic effect . For some reason it worked out so that you can reduce the androgenic compounds only with his anabolichnostyu , but anabolichnost could reduce without prejudice to androgens ( eg, the drug Proviron ) . Therefore , synthetic derivatives of testosterone, although less contribute to the appearance androgenobuslovlennym side effects , have less anabolic effect than testosterone. And testosterone has been and remains the “king ” among anabolic means , despite its androgenistost 🙂 .

Testosterone esters

But the main problem with testosterone replacement therapy were frequent injections , and no side effects, because substitution therapy of patients had no other choice. A injections had to put every day . Because the body of a healthy male every day produced 10- 20mg of testosterone . The very same testosterone is rapidly metabolized by the body , ie quickly used and divided in the liver . So put a large dose of testosterone for future use without success.

They tried to take testosterone orally, but in a way he did not have any therapeutic effect . Then come up with methyltestosterone tablets – a substance obtained by adding to the formula of testosterone methyl group , which allowed the drug does not disintegrate during passage through the stomach and enters the bloodstream . In the body, methyl group is separated from testosterone, and he gets into the blood. All anything , but the connection got very toxic . From methyltestosterone for a couple of weeks, you can get ” jaundice “( on the basis of methandrostenolone methyltestosterone was developed , it became 100 times less androgenic than its predecessor , but remained the same as toxic ).

The next step in the development of steroid was esterification of testosterone. In order to increase the duration of the testosterone molecule began punching him in the ether ( the ether and other subtleties, you can read in the literature on organic chemistry ) . Getting in the body , the ether under the influence of specific enzymes begin to gradually disintegrate and eventually release a prisoner there testosterone.

Various esters have different half-life in the body, so the duration of the esters of testosterone is different . The most fast , thus obtained products is testosterone propionate – it has effect within 1-2 days , following on the duration of action is phenylpropionate and izokapronat they are about 2 weeks, and one of the ” LPs ” testosterone – a testosterone decanoate Which operates for 3-4 weeks. There are other drugs – testosterone enanthate , cypionate , undecanoate , etc.

When receiving esterified testosterone , has absolutely no value what you have . After the injection start “timer ” after which time the entire broadcast decompose releasing all contained therein testosterone . Ie There is no difference in whether you put yourself at a time 50mg or 150mg of testosterone propionate , all testosterone is released into the blood in 2-3 days. In addition, if you are using testosterone esters , it must be borne in mind that 100 mg testosterone decanoate , for example , does not contain 100mg of testosterone , and 100 – (weight attached ether ) mg of testosterone. And the longer the duration of action of the ether compound of testosterone , the more specific proportion of the ether in the compound, while the proportion of testosterone correspondingly less. Therefore, 100 mg testosterone propionate in more than 100 mg decanoate.

Birth Of sustanon

Thus , different preparations of testosterone obtained by esterification have different validity period. But concrete action in the body testosterone esters ? If you look at the recommended (therapeutic ) doses of drugs then get the following picture : propionate kolyat a day or two doses of 25- 50mg (which is obtained about 10-15 mg / day) , testosterone enanthate 200 mg once in the three weeks (also where A 10 mg / day ) . From this we can conclude that therapeutic doses of testosterone designed to artificially maintain the level of testosterone in the range of 10 mg per day.

What is the difference in what kind of drug use ? (Except of course the number of holes from the shots :)) And the difference is that esters decompose in the body about evenly – as soon as the drug enters the body it begins to produce testosterone in the blood at a speed of some ” design ” of the drug (depending on what the Air used ) and individual characteristics of metabolic person receiving the drug . The whole thing can be vividly imagined as a dropper (ether ) which drips equal amount of testosterone in the blood for a time. And , try a dropper rig it so that it dripped about 10mg of testosterone per day.

But what’s the catch ? And that testosterone itself in different ways to “play ” in the body – someone he quickly binds to globulin ( blood protein ) and becomes temporarily inactive, someone quickly destroyed by the liver, someone has long collected and due to lack of testosterone receptors become very high , etc. Therefore , each of testosterone preparations have their drawbacks – high-speed esters can rapidly raise the level of testosterone , but just as quickly , and ” evaporate “and the long-running esters too long developing its effect, so that the therapeutic effect after a couple of weeks after the injection.

But now , scientists got together and came up with a drug Sustanon ! They are ” collected ” him out of four testosterone esters ( in truth, propionate , decanoate , and so it is not esters , and salts derived from the reaction of testosterone and related substances, and dissolved in oil) – have taken testosterone propionate 30 mg, testosterone phenylpropionate 60 mg testosterone izokaproat 60 mg and testosterone decanoate 100 mg . (Thus was born Sustanon , Organon noble son)

Why is it all mixed? Here is what writes on this subject producer Of sustanon company Organon in its statement: ” Due to a combination of four different esters of testosterone action Of sustanon -250 is developed in a short time after injection and maintained for approximately 3 weeks . Sustanon -250 is generally well tolerated , and no negative impact on liver function .The latter is very important, because if the liver is damaged, the person in the blood becomes much testosterone- binding globulin and free testosterone , respectively, is small.

Reference :

In blood, testosterone and dihydrotestosterone binding proteins , mainly globulin. Binding globulin sex hormone produced in the liver and has a molecular mass of about 100 000 daltons . In cirrhosis, gipertiroze and hypogonadism in men the level of binding globulin sex hormone in the blood serum increased . The concentration of this globulin in the blood is the main factor determining the balance between androgens and estrogens. About 98 % of testosterone in the blood is associated with the globulins state , and the rest of his number (about 2%) is free, able to bind receptors of target tissues and have biological effects. Binding globulin sex hormone , has a greater affinity for testosterone than estrogen.

In the prepubertal period, the concentration of globulin , sex hormone binding is the same for boys and girls at puberty in males there is a significant reduction in its level , and for women the concentration of this globulin in the blood 2 times higher than its level in serum blood of men . It is known that the concentration of testosterone in men is 20 times higher than its level in women , but the level of free testosterone in men above 40 times . In men, testosterone is the rate of 6-7 mg per day , the concentration of blood 8,5-27 nmol / L in women – about 1 mg per day and the blood level of 0,6-1,9 nmol / liter. Destruction of testosterone under the influence of 17b- dehydrogenase occurs primarily in the liver , where its metabolites are associated with glucuronic and sulfuric acids and eksretiruyutsya with urine in the form of 17- ketosteroids , androsterone, which are represented , epiandrosteronom , etiocholanolone and DHEA . ( Endokrinologiya. MI Balabolkin .)

But back to To sustanon whose action can be represented in the form of four infusions …: ) , but better let’s another analogy . Imagine a large piece of ice ( Sustanon ) , who put on the floor near the stove ( metabolism rights ). As soon as you put it next to the stove , that his party , which is closer to the fire begins to melt faster than the portion that is farthest from the fire ( but it too will melt only much slower). Evolved in this water can be compared with testosterone released from various esters in the body when taking Of sustanon .

Let’s do a rough calculation , and must immediately be noted that all four broadcast begin to ” thaw ” in the body from the very beginning , only with different speeds.

Of course , given the calculations do not pretend to high accuracy , and based on the assumption that testosterone is released from the ether in a linear progression . But this is only calculation, a rough estimate .

And what do we still have ? Of all these figures and graphs can be seen that in the preparation Sustanon -250 ” automatic ” old trick of drug therapy , which lies in the fact that the first treatment of humans ” load ” the drug , and then transferred to a supporting dose (ski-slope approach – English . letters . ” ski slope “) . Ie if, for example , the same thing to try to do with methandrostenolone , it would look like this : the first three days the person drinks to 5 tablets (1 tab. = 5 mg ), following 11 days, 3 , and the remaining 7 , one tablet.

Testosterone and Sustanon

The above graph and table show the dose of testosterone, obtained athlete as a result of the release of testosterone molecules from its air ” attachment ” . Ie it ‘s like stabbing the same dose of free testosterone ( eg testosterone suspension ) . How does this look at testosterone levels in the body ?

To answer this question we must again make some calculations : a healthy male body every day, producing about 10 mg of testosterone, possibly the same used or deactivated ( destroyed in the liver and excreted in the urine ). Hence we can assume that the level of testosterone is given by

([ received testosterone ] + [ this level of testosterone ] – 10 )

received testosterone – testosterone produced in the human body or produced externally ( pills , injections )

present level of testosterone – testosterone levels existing at the time of receipt of the new dose.

10 mg – the amount of testosterone which, we assume every day is lost .

Ie to determine the level of testosterone in human blood after injection Of sustanon we add up the dose received yesterday and today and it takes 10 . In favor of that day is 10mg of testosterone is derived from the fact that it appears at least 20mg , then the testosterone levels resulting from the injection Sustanonom descend to 0 to 6- th day , and did not rise to above as the subsequent doses received from the depot be processed immediately.

So , using our formula , we obtain the schedule :
Here we see that under the influence of an injection Of sustanon -250, (for convenience we assume that a person does not produce its own testosterone ), testosterone levels gradually increases and reaches a maximum in the 14- th day , accounting for 76mg and then gradually decreased , apparently reaching 0 to 24- th day.

But in fact, determine the level of testosterone in the blood is not so simple . Much depends on the individual organism ( the number of androgens receptors , the presence of specific enzymes, the rate of metabolism in which testosterone and himself intervenes , and others). Therefore, given calculations are just estimation.

Sustanon medicine

The benefits of such a ” design ” Of sustanon obvious: patients often do not have to go to the injections (once pricked himself and walked for three weeks ) , and this is a significant advantage , because with frequent injections of oil solutions may have ” bumps ” at the injection site . They are formed due to accumulation of oil (” reservoir “) and because of scar tissue at the injection site zashramovyvayutsya , becoming thicker and thicker. The presence of cones , significantly reduces the effectiveness of injecting drugs , and brings little pleasure to the patient .

Another plus Of sustanon that when it is used simply to comply with dosing regimen – just think how much hassle to drink tablets of such a scheme, because the head swim , “When , how many tablets to drink? 5? 3? 1? “. But when taking hormonal drugs , with which are all androgens and anabolic steroids, it is important to observe the correct dosage regimen . For example, when hormone therapy is not recommended to ” make up ” missed medication , because This may cause an overdose and associated side effects. And the composition of the four esters has lowered the relative toxicity of each drug. In short, Sustanon and simplifies life for patients and doctors .

Sustanon and pitching

Ratio of strokes to To sustanon , as we have noted above , is twofold . Some people like it very much , but someone did not see him much use. Why are there such contradiction? Most likely , because many do not understand the mechanism of action Of sustanon , which was described above .

For example, consider a quote from the book Grundinga P. and M. Bachmann ” Anabolic steroids “, ” Sustanon inject more often than once a week , with the interval between injections can be up to 10 days . The dosage in bodybuilding and triathlon ranges from 250 mg every 14 days up to 1000 mg or more per day . Since such high doses should not be advised and, fortunately , in most cases they are not practiced , taking as a rule, 250 – 1000 mg per week . For the majority of enough doses of 500 mg per week , which is often reduced to only 250 mg Of sustanon a week, and combined with some oral steroids .

Typically , athletes inject Sustanon twice a week.

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