Publicado em

Testosterone cypionate

Testosterone cypionate is a long-chained testosterone ester which comes in the form of oily solution. Its half-life is about 2 weeks. Due to the long half life its ability to cause water retention is more expressed than in other steroids.  Usually bodybuilders take it in muscle gaining combinations.

It performes the same functions as endogenous testosterone, which is responsible for major male traits  – libido, aggression and muscle growth. It affects anabolic receptors which leads to nitrogen retention in muscle cells and subsequently causing synthesis an accumulation of proteins. Besides it increases the level of IGF1, which is also an anabolic hormone.

Testosterone cypionate is an aromatizable steroid, therefore it can cause estrogen related side-effects – gynecomastia, water retention, decreased libido and testicular atrophy. However, one can prevent these adverse effects if the substance is taken correctly.

Effects and Side-effects of Testosterone Cypionate

This anabolic steroid significantly increases muscle mass, strength and endurance. However, due to water retentions the muscle mass may decline by 30% after the end of a cycle.

Besides, due to aromatization it is necessary to take aromatase inhibitors (:letrozole:, :anastrozole:) and estrogen blockers (:tamoxifen:, :clomiphene:). The antiestrogens will make your cycle safe. For more information about these compounds, see the article Terapia pós-ciclo

Like testosterone itself, Cypionate can cause androgenic side-effects which include acne, body hair growth, baldness (in case of genetic predisposition) etc. In order to prevent these side-effects one should take Propecia (:proscar:), which blocks the transformation of testosterone into dihydrotestosterone.

Dosagem e uso

Though Testosterone cypionate is a long acting steroid one should do a weekly injection in order to keep the high concentration of steroid in the blood.

The usual dosage for muscle gaining cycle is 250-500mg/week. It is not recommended to exceed the dosage of 800-1000mg/ week as it doesn’t provide further gains, while the risk of side-effects significantly increases.

If the length of your cycle exceeds 4 weeks, you should take gonadotropin at the dose 500 IU /week starting from the 3rd week.

Combinações

You can combine Testosterone Cypionate with :nandrolone: (200mg/week). The dosage of Cypionate is the same (200mg/week).

You can buy Testosterone Cypionate aqui.

Publicado em

Nandrolona

Nandrolone – (aka Nandrolone Decanoate, 19-nortestosterone, Deca etc.) is an anabolic steroid, which is naturally produced in human organism after heavy exercises or during pregnancy. It has high anabolic and low androgenic properties.

Its molecular structure lacks carbon in position 19, therefore it is similar to progestins. That is why its androgenic properties are low, as compared to testosterone.  However, progestin-like structure and its ability to bind to progesterone receptors entails certain side-effects.

Steroid characteristics

Anabolic properties – 150% (comparing with testosterone)

Androgenic properties – 30%

Transformation into estrogens – low

Liver toxicity – low

Available forms – injection

Duration of action – 2 weeks (half-life – 7 days)

Doping tests – detectable up to 1.5 year

Endogenous testosterone suppression – high (owing to progestin-like structure)

Efeitos

  • Increases muscle mass (one can get up to 8 kg of muscle mass during Nandrolone cycle
  • Strengthens bones (initially it was a cure for osteoporosis) and ligaments
  • Reduces joint pain
  • Increases endurance
  • Improves immunity (even in AIDS patients)
  • Improves the absorption of nutrients in intestine

Efeitos colaterais

Nandrolone belongs to safe steroids. Due to low androgenic properties acne, alopecia, prostate enlargement are extremely rare. Usually they occur when the recommended dose is exceeded many times.

Though Nandrolone can transform into estrogens without aromatase, the rate of this conversion is very low (5 times less than in testosterone) Therefore Nandrolone has no estrogen related side effects (e.g gynecomastia). They are possible only in case of overdose. All above said explains the popularity of this substance among athletes.

It may also cause headache, rhinitis, back pain, rash, high blood pressure, abdominal pain, irritability,  depression.

Progestin-related side effects

By attaching to progestin receptors in hypophysis, nandrolone increases prolactin production and inhibits gonadotropic hormones. Prolactin in its turn may decrease the endogenous testosterone production (thus decreases libido) and rarely may cause gynecomasia.

However, these side-effects can be easily prevented by using prolactin inhibitor – Cabaser (Cabergoline). This drug also greatly enhances sexual drive and improves the quality of orgasm (both in men and in women).

Besides it was recently discovered that Winstrol can act as antiprogestin agent, so one can combine Nandrolone and Winstrol together.

Dosagem e uso

This drug causes slow but steady growth of muscle mass. Unlike testosterone and similar agents, it doesn’t produce pullback phenomenon, so the gained muscles remains.

The usual dose is 200 mg/week, however you should start with lower dosage and gradually increase it. The length of Nandrolone cycle is 2 months; however, some bodybuilders use it up to 6 months.

During Nandrolone cycle it is obligatory to take testosterone in order to prevent unwanted effects of low testosterone and progestin.

Do injections once a week. Due to long activity (about 2 weeks) you don’t have to do frequent injections. However, if the dosage is high, it’s better to divide it into 2-3 injections.

The maximal dose is 600mg/week, but in this case the risk of side effects increases. Therefore, one can achieve better results doing two cycles at moderate doses with a break, rather than in one cycle at extreme doses.
In order to get maximal results one should take sports nutrition and follow a mass gaining diet.

PCT

If your cycle is longer than 2 months than chorionic gonadotropin is required. In case you didn’t use gonadotropin during your cycle, use it in the end, before (!) PCT.

You can prevent progestine side-effects by using bromocriptine (1.25mg 2 times a day), also starting from 2nd week and ending 2-3 weeks after the final injection.

However it’s better to take Cabaser instead of bromocriptine (0.25mg every 4th day during the course and 2-3 weeks after it).
You can also reduce prolactin production by taking Winstrol from the second week of your cycle.

In order to restore hypothalamus-pituitary-testicles axis you need to take Citrato de clomifeno (50-100 mg with a gradual decrease) starting from the last week of a cycle and ending 2-4 weeks after it. Tamoxifeno is bad option in this case, because it increases the number of progesterone receptors and thus, increases sensitivity.

Combinations with Nandrolone

Nandrolone makes a good combination with Testosterone, which helps to reduce the side effects of the former. It is highly advised to use testosterone with Nandrolone. The dosage of testosterone should exceed the Nandrolone doses approximately two times.

One can also combine it with Dianabol e.g. Dianabol  20-40mg/day , Nandrolone 200mg/week, however testosterone is also necessary in this cycle.

The best combination with Nandrolone :

Nandrolone 100-300mg/week

Enantato de testosterona / Cypionate / Sustanon  500mg/week

Cabaser (Cabergoline) – 1 tab/week

Aromatase inhibitors.

You can buy Nandrolone aqui

Publicado em

Clenbuterol – a drug for weight loss

In the beginning Clenbuterol (aka Clen) – was used as a cure for asthma. Nowadays it is a drug of choice among bodybuilders and other athletes owing to its fat-burning properties.

In cutting cycles it is usually stacked with Zaditor (Ketotifen) to quicken the weight loss. It does not belong to steroids, therefore women can use it without the hazard of androgenic adverse effects. Its half-life is about 35 hours

Como funciona

Clenbuterol has affinity to beta-2 adrenergic receptors in fat and muscle tissues. This binding initiate a chain of reactions, which causes buildup of cAMP. In its turn cAMP induces enzymes that initiate lipolysis in fat cells.

The effects of Clenbuterol

  • Increases the levels of noradrenaline and epinephrine, both of them are powerful lipolitic agents.
  • Enhances metabolism
  • Stalls lipoprotein lipase, thus blocking fat deposition.
  • Increases the production of thyroid hormones – which also act as fat burners.
  • By inhibiting ubiquitin-mediated proteolysis, Clenbuterol provides anticatabolic effect. Thus, it prevents destruction of muscles, which is important for athletes.
  • Activation of Crtc / Creb proteins causes anabolic effect
  • Enhances stamina and strength
  • Increases mental activity
  • Decreases appetite

Dosagem e uso

The common dosage for men is 120-140mcg/day. Women should take it at the dosage 80-100mcg/day.

The length of a cycle is two weeks. After that period the tolerance occurs and efficiency is reduced. Then you have to take a two-week break using Zaditor, and then repeat the cycle. If you don’t use Zaditor, you have to prolong the recovery period.

Note: For optimal results you should follow a weight-losing diet, take BCAA and cortisol blockers during your cycle.

Clenbuterol without Zaditor

(days : dosage)

1: 20μg (0.02mg)

2: 40μg (0.04mg)

3: 60μg (0.06mg)

4: 80μg (0.08mg)

5: 100μg (0.10mg)

6-12: 120μg (0.12mg)

13: 80μg (0.08mg)

14: 40μg (0.04mg)

Break (more than 2-week)

Gradually increase the dosage within the 1st week. Take it in the morning in order to avoid insomnia. When the dosage becomes higher, divide it into two portions and take them in the morning and after lunch.

Clenbuterol + Zaditor (Ketotifen)

Zaditor is an antiallergic drug, which restores the sensitivity of receptors to Clenbuterol. This happens owing to inhibition of phosphodiesterase – enzyme that regulates cAMP-dependent metabolism.

Therefore with the help of Zaditor, you can speed up the weight loss by 15% and prolong your cycle up to two months. Besides, Zaditor helps to reduce agitation, tremor and other side-effects.

(Days : dosage)

1: 20μg

2: 40μg

3: 60μg

4: 80μg

5: 100μg + 1mg Zaditor

6-27: 120μg + 2mg Zaditor

28: 80μg + 2mg Zaditor

29: 50μg  + 1-2mg Zaditor

30: 33-35μg + 1mg Zaditor

Break (2 weeks)

Note: Take Zaditor at night, Clenbuterol – in the morning.

Side effects (frequency)

  • Heart palpitation (60%) – you can eliminated it by beta-1-adrenoblockers (5 mg of Zebeta (Bisoprolol), or 50 mg of metoprolol in the morning).
  • Tremors (20%) – (you can remove the symptoms by Zaditor)
  • Sweating (10%)
  • Insomnia (7%) – (you can remove the symptoms by Zaditor)
  • Anxiety (6%) (you can remove the symptoms by Zaditor)
  • High blood pressure (6%) (you can remove the symptoms by 5 mg of Zebeta, or 50 mg of metoprolol in the morning.)
  • Diarrhea (5%) – usually occurs only during initial stage of drug administration
  • Nausea (3%)
  • In rare cases headache is possible, mostly due to high blood pressure.

As you can see most of the side effects can be removed by Zaditor and Zebeta (or metoprolol). Besides some side-effects are pronounced during initial stage of Clenbuterol intake. They may completely disappear in several days. Do not use alcohol during Clenbuterol cycle.
You can buy Clenbuterol aqui

Publicado em

Enantato de testosterona

Testosterone enanthate is a representative of testosterone esters. Probably this is one of the most favorite anabolic substances among bodybuilders. It has long period of action, which depends on metabolic rate and hormonal background of an athlete.

On average, it remains active for 2 weeks (its half-life is about 7 days). Usually athletes do a weekly injection to keep high concentration of the hormone in blood.

Steroid characteristics

Anabolic properties – 100%

Androgenic properties – 100%

Transformation into estrogens – Yes (aromatase inhibitors are required)

Suppression of hypothalamus-pituitary-testicles – Yes

Liver toxicity – No

Available forms – injection

Duration – 2 weeks

Doping test – detectable during 3 months

Efeitos

The major benefit of Testosterone enanthate usage is a rather fast gaining of muscular mass and strength. This is the reason of its popularity among bodybuilders and powerlifters.

Testosterone enanthate can also solve the joint problems in athletes who suffer from joint pain, however :decadurabolin: and HGH are more preferable for these issues.

It also induces the regenerative mechanisms, improves general well-being and increases endurance.

Efeitos colaterais

The major problem of testosterone enanthate usage is transformation into estrogen, which can cause estrogen related adverse effects: gynecomastia, water retention. However, with the invention of anti-estrogens this is not a problem anymore.

Note that aromatase inhibitors (e.g. :letrozole:) are taken during the cycle. Meanwhile estrogen blockers – after the cycle (when the action of steroid is over, therefore you need to check its half-life). As testosterone enanthate suppresses the axis of hypothalamus-pituitary-testes, estrogen blockers (e.g. :clomiphene:) are necessary to restore the production of endogenous testosterone.

In case of prolonged cycles, high doses or combinations, human chorionic gonadotropin is necessary to use starting from the 3rd week and ending in 2-3 weeks after the end of a cycle.

Testosterone enanthate can also cause androgenic side effects such as acne, high blood pressure, increased aggression, baldness etc. Women should avoid taking this substance due to high risks of virilization.

Dosagem e uso

The effect of this steroid is dosage dependent. The usual dosage is 250-500mg/week, which is injected once a week (or two times at regular intervals if the dose is high). Commonly the cycle lasts 2 -2.5 months. PCT begins in two-three weeks after the end of a cycle. For optimal results you should follow a mass–gaining diet including sports nutrition.

Testosterone enanthate is an aromatizable substance. So, in order to avoid estrogen-related adverse effects one should take aromatase inhibitors starting from the 2nd week of a cycle. This therapy must go on up to the one week after the end of a cycle.

In order to keep the gained muscle mass one should take cortisol blockers after the end of a cycle.

Combinações

For mass-gaining purposes this steroid is stacked with :anadrol:, :dianabol:, :decadurabolin: and :parabolan.

Example of stacking

Deca Durabolin 200-250mg/week

Testosterone enanthate 500mg/week.

Note: aromatase inhibitors are necessary in this cycle.

For cutting purposes Testosterone enanthate makes good combinations with :stanozolol: or :oxandrolone (moderate doses).

You can buy Testosterone enanthate aqui.

Publicado em

Halotestina (fluoximesterona)

Fluoxymesterone (Halotestin, Halotest) is an oral steroid with high androgenic and anabolic properties. Its major application is in increasing strength, muscular hardness and aggression, without increase of body weight. Therefore it is taken before competition by those who want to keep weight category (power athletes, fighters etc.). Halotestin has high liver toxicity.

Steroid characteristics

Anabolic properties – 1900% (comparing to testosterone)

Androgenic properties – 850%

Transformation into estrogens – No

Suppression of HPG axis – Yes

Liver toxicity – High

Available form – tabs

Duration – 6-9 hours

Doping test – detectable during two months

Pharmacological properties and effects

In medical practice Halotestine was used to treat hypogonadism and delayed puberty in men, as well as breast cancer in women. However, nowadays it is out of use. Fluoxymesterone is about 5 times stronger than methyltestosterone.

Halotestine is close relative of methyltestosterone. It is produced by altering testosterone molecule in 3 positions: a 17-alpha-methyl group, an 11-beta-hydroxy group, and a 9-fluoro group.

  • 17-alpha-methyl group prolongs the half-life of the substance by neutralizing the destructive effect of liver enzymes.
  • 11-beta-hydroxy group blocks enzymatic transformation of steroid into estrogen, thus preventing estrogen-related side-effects (gynecomastia, water retention etc.).
  • 9-fluoro group increases its androgenic properties by facilitating reduction of this steroid in 5a position, which leads to transformation into dihydrotestosterone.

By increasing the amount of red blood cells Halotestin improves endurance and performance – more erythrocytes deliver oxygen to muscles with higher efficiency. Fluoxymesterone also has fat-burning properties, though there are much safer substances for this issue, e.g. :winstrol:, :oxandrolone:.

Efeitos colaterais

Owing to high level of dihydrotestosterone, which is 8.5 times higher than in testosterone, the side-effects of Halotestin are similar to other androgenic steroids. They include hypertrophy of prostate, prostatic adenoma, hair loss (in case of genetic predisposition), growth of body hair, acne etc. Women should avoid using it due to high risks of virilization.

There may be cardiovascular problems – high blood pressure and increased cholesterol. Halotestin is toxic to the liver. In order to reduce above mentioned side-effects you should follow a healthy lifestyle: avoid taking alcohol or other liver unfriendly substances, include omega 3 fatty acids into your diet, keep your skin clean. In case of evident side-effect discontinue usage of Halotestin.

Dosagem e uso

The optimal daily dosage of Fluoxymesterone is 10mg. You should not exceed the maximal dosage of 20mg/day. Prolonged usage (more than 6weeks) may lead to sexual dysfunction.

We have to remind that Halotestin is not efficient in gaining mascle mass (growth of muscle tissue) even in combinations with other compounds. However it is very powerful substance in increasing strength and aggression. Therefore you should take it shortly before the competition.

You can buy Halotestin aqui.

Publicado em

IGF-1 – Insulin-like growth factor-1

Insulin-like growth factor-1 (also known as somatomedin С, IGF-1) is a peptide hormone, which is similar to insulin. It is the main intermediate of growth hormone activity. Therefore it is responsible for childhood growth and besides produces anabolic effect in adults, initiating muscular hyperplasia.

Its effects are identical to the effects of human growth hormone (HGH), however the latter doesn’t act independently. Today we know that HGH forces the liver to release IGF-1 into the blood, which in turn produces “growth hormone effects” – fat burning, growth of muscle fibers etc.

IGF-1 has different varieties: Mechanical Growth Factor (MGF), LR3, DES. IGF is taken parenterally (using syringe). 100 mcg of IGF-1 is equal to 16-25 IU of HGH.

IGF-1 LR3 and IGF-1 DES

There are several types of IGF-1: IGF-1 LR3 and IGF-1 DES. Since the natural molecule (70 amino-acids) has rather short half-life (about twenty minutes) its effects are short-term. Therefore scientists modified the molecule and created 2 stable peptides:  IGF-1 LR3 (83 amino-acid residues) and IGF-1 DES (67 amino-acid residues).

Both types have common effects with endogenous IGF-1, but different in strength and duration of action. IGF-1 LR3 is about 2 times stronger than endogenous IGF-1, its half-life is about 25 hours. It effectively prevents the uptake of glucose, thus making the organism burn fats as a source of energy.

IGF-1 DES lacks the first three amino-acid residues of natural sequence, therefore it does not bind to plasma proteins. It is about 10 times more active than natural analogue, its half-life is about 30 minutes. As for bodybuilding purposes, IGF-1 DES is more preferable, since it affects more receptors simultaneously, including those that were affected by lactic acid. Therefore it is more efficient in initiating muscular hyperplasia than IGF-1 LR3.

Though they are not yet clinically tested, there are reports about their application in bodybuilding and both types showed great results.

According to these reports IGF-1 LR3 injections were administered every day at the dose 50-150 μg. Desensitization occurs in 3-4 weeks.

Due to shorter half-life one can make IGF-1 DES injections (50-150μg) several times a day, preferably before and after training. The usual length of a cycle is four weeks.

Effects of Insulin-like growth factor-1

The main advantage of this substance is stimulation of muscular hyperplasia. This is especially important for aged athletes, as it is rather difficult to initiate muscular hyperplasia with age.

You can achieve optimal results by combining IGF-1 injections with special training: 10-12 sets per muscle group with 12-20 repetitions per set (with a minimum pause between sets). Follow a protein-and-carbohydrate rich diet during your cycle.

Besides IGF-1 has fat burning effect. In this aspect it is more efficient than synthetic :somatropin:. However, it has quite different mechanism of action, therefore one can expect synergistic effect in combination of IGF-1 with HGH.

Conclusions

The optimal dose of Insulin-like growth factor-1 is 100 μg per day. You can make local injections (to stimulate definite group of muscles) or systemic (to achieve fat burning effect). There are reports that daily injections are not necessary, the optimal solution is 2-4 injections per week (on training days).

While using this substance one should be very attentive to your body, since it can also stimulate the growth of different kinds of tumor.

IGF-1 has also beneficial effect on cardiovascular system and can restore heart muscle.

The effect of IGF-1 on female organism is not yet studied. However, it becomes a very promising substance for fat burning issues.

You can buy IGF-1 aqui.

Publicado em

Sustanon 250

Sustanon 250 is a mix of various testosterone esters, also known under such trade names as Sustamed, Tetrasterone, Sustager etc. In medical practice it was initially used as a hormonal replacement therapy in patients with insufficient testosterone production.

Sustanon formula includes 4 different testosterone esters:

Note that the storage of testosterone in bottles with rubber caps is strictly prohibited.

Each ester has its own rate of absorption and time of action. This combination allows you to keep high level of hormone for a very long time. Therefore there is no need to do frequent injections. For instance, for medical purposes patients take Sustanon once in every three weeks. Some bodybuilders regard Sustanon as a combination, however it is not so, as each ester eventually transforms into testosterone.

Effects of Sustanon

Sustanon has the same effects as testosterone itself.

Gaining of muscle mass (about 6kg/month)

Anticatabolic effect

Aumenta o apetite

Improves endurance by increasing the number of erythrocytes.

Increased libido (during Sustanon cycle)

Tempo de Detecção

Up to 3 months.

Efeitos colaterais

As well as testosterone, Sustanon is prone to aromatization. Therefore it can cause estrogen related side-effects – gynecomastia, water retention, suppression of testosterone production etc. You can prevent these side effects by using antiestrogens, preferably aromatase inhibitors. Selective Estrogen Receptors Modulators (SERMs), such as Tamoxifeno, are taken only during PCT.

Due to suppression of natural testosterone production such side-effect as testicular atrophy is possible. If your cycle doesn’t exceed eight weeks you can prevent it by taking anti-estrogens. In case of longer cycles you should take :gonadotropin:.

As testosterone is converted into dihydrotestosterone, Sustanon can cause androgenic side effects: hypertrophy of prostate, baldness, acne, virilization in women. Also, flu-like condition may accompany your cycle. Sustanon can increase the amount of bad cholesterol in the blood. However you can prevent it by taking Omega-3 fatty acids during your cycle.

Dosagem e uso

Usually bodybuilders take Sustanon for gaining muscle mass. Make sure you don’t have contraindication before taking it.

The cycle of Sustanon lasts 8-10 weeks. If your cycle is longer than 8 weeks the use of gonadotropin is necessary. Inject the substance once a week at the dosage of 250-500mg intramuscularly.

Take aromatase inhibitors (AI) starting from the second week of your cycle (usually 0.5 mg anastrozole every other day). You should stop taking AI in 1-2 weeks after the last injection.

In 3 weeks after the last injection start taking tamoxifen, which is a part of PCT. Testosterone boosters are also necessary within 3-4 weeks in order to restore the natural testosterone production.

In order to increase the effectiveness of your cycle take sports nutrition and follow a mass gaining diet.

Combinações

You can combine Sustanone with :nandrolone: – for a mass gaining cycle, or with :winstrol: – for a cutting cycle. Combination can reduce the frequency of side effects and improve the effectiveness of your cycle.

Publicado em

SARMs – Selective Androgen Receptor Modulators

SARMs – Selective Androgen Receptor Modulators

SARMs belong to a group of molecules that selectively bind to sex hormone receptors. By their action they are similar to SERMs -Selective Estrogen Receptor Modulators (e.g. :clomiphene: and :tamoxifen:) with the only difference that they bind to androgen receptors.

As SARMs are not steroids, they do not undergo conversion by steroid enzymes, therefore there are no undesirable side-effects. The initial aim of SARMs was to reduce the adverse effects of testosterone on prostate. But later scientists found out that they can increase muscle mass. Since that time bodybuilders started to test these compounds on themselves even before clinical trials.

In the following article it was shown that GTx-024 (ostarine, enobosarm) is well tolerated and produces a dosage dependent gain of muscle mass in elderly men and postmenopausal women.

For instance, according to the trials  3mg of Ostarine (orally) during 12 weeks increases lean muscle mass by 1.4kg and reduces body fat by 300 grams without any physical load. It is also effective to prevent muscle loss (due to excessive catabolism) in cancer patients.

Nowadays there are several types of SARMs which have already passed human trials and very soon will appear on the market. However none of them is actually selective. In general they have high anabolic properties. The ratio of anabolic to androgenic properties vary from 3:1 to 10:1 (comparing to testosterone, which is 1:1)

Almost all selective androgen receptor modulators are freely available in the form of tablets. One should also mention that they don’t have liver toxicity. SARMs  became an optimal option for females, due to minimal influence on libido, blood cholesterol, liver and so on.

The major representatives of SARMs

Ostarine (MK-2866, GTx-024, Enobosarm) – affects bones and muscles

BMS-564,929 – muscle tissue

:ligandrol: (Anablicum, LGD-4033) – similar to Ostarine

LGD-2226 – bones and muscles, the trials are stopped due to high toxicity

S-40503 (Andarin) – mostly bone tissue, treatment of osteoarthritis (the research is suspended)

S-23 – male contraceptive

YK-11 (Myostine, Myostan) inhibitor of myostatin (under development)

RAD140 (Radarine, Radium) anabolic effect, increases endurance and has a neuroprotective effect

Reversol (Reverol, edrophonium, Endorol, Stenabol or SR9009) increases endurance (due to the formation of new mitochondria), treatment of obesity, muscular hypertrophy. It binds to Rev-ErbA, which in its turn performs different regulatory functions in human organism.

:ibutamoren: – Nutrobal (MK-677) – stimulates growth hormone production.

AICAR – increases endurance

Publicado em

Masteron (Drostanolone Propionate)

Masteron (also Drostanolone, Drolban, Metormon, Permastril, Mastager, etc.) is an anabolic steroid which originates from dihydrotestosterone. It has high androgenic and moderate anabolic properties. Masteron is not an aromatizable steroid (i.e. there is no conversion into estrogen), moreover it acts as aromatase inhibitor.

Therefore there is no risk of estrogen related side-effects, such as gynecomastia and water retention. In clinical practice it was used as a cure for breast cancer in women, however, due to the high risks of virilization, it is practically out of use today.

Due to its anti-estrogenic properties and slight diuretic effect Masteron became popular among bodybuilders. They take it to keep muscle mass and strength during cuting cycles.

Drostanolone is of special interest among those athletes who want to improve muscular endurance before competition without gaining of excessive bodyweight. Moreover it increases strength and has apparent fat burning effect. For example Drostanolone cycle can reduce the amount of body fat by 5-7%.

All above mentioned features of Masteron make it attractive for athletes of all types of sports. This substance is also useful during weight losing diet. Its application maintains the muscle mass and reduces catabolism.

Side Effects of Masteron

As we said above Drostanolone is not aromatizable, therefore gynecomastia, water retention and high blood pressure do not occur. Nevertheless androgenic side-effects are possible: aggression, acne, alopecia, prostate hypertrophy and virilization in women. One should also mention that Masteron has low liver toxicity.

Dosagem e uso

The optimal dosage of Masteron is about 400-500mg/week. Higher doses do not produce further improvement of results, however the risk of side-effects may increase. As Drostanolone propionate has a short chain, you should take it three times a week (or EOD).

Combinações

Owing to high affinity to androgen receptors, it makes good combinations with such steroids as :winstrol: or :anavar:. They have less interaction with androgen receptors, therefore this stacking may produce synergistic effect during cutting cycle.

For a bulking cycle you can combine it with :testosterone-p:. However this combination suppresses natural testosterone production, so :gonadotropin: usage is required. Also bodybuilders combine Masteron with :trenbolone: or :boldenone:.

Publicado em

Primobolan

Primobolan (Methenolone) is an anabolic steroid, which originates from dihydrotestosterone. It has weak androgenic and moderate anabolic properties. This hormone is available in the form of tablets (Oral Primobolan), and injectable form (:primobolan:).

Injectable version of this substance (Primobolan Depot) is an Enanthate ester of Methenolone, which has prolonged action (about two weeks). It is regarded as one of the safest steroid. In medical practice it was successfully applied in treatment of underweight children, osteoporosis and sarcopenia. The major inconvenience is that its injection is rather painful.

A tablet version of Primobolan (Methenolone acetate) has shorter period of action (approximately five hours). Unlike other tablet steroids, Oral Primobolan has low liver toxicity. Nevertheless most bodybuilders prefer injectable version of Methenolone due to lower price and higher bioavailability of the hormone.

Characteristics

Anabolic properties – 88% of testosterone

Androgenic properties – 44% of testosterone

Transformation into estrogens – no

Liver toxicity – low

Available forms – tabs, injections

Half-life – 5-20 hours (tablets); 4-7 days (for injections)

Doping test – detectable during 100 days (tablets), or 6 months (injections)

Efeitos

Comparing to :decadurabolin: the anabolic effect of Methenolone is rather mild. Therefore most bodybuilders use it during cutting cycles, when the main goal is not to gain muscle mass but to preserve it.

Efeitos colaterais

As Primobolan is not an aromatizable steroid, there is no risk of estrogen-related side-effects (gynecomastia and water retention).

Methenolone may decrease the level of natural testosterone synthesis to a little degree. However this effect is much weaker than in Testosterone and Nandrolone. For instance, the cycle of Oral Primobolan at the dose of 40mg/day can suppress the levels of endogenous testosterone by 50%.

In case of long cycles or high doses, the usage of gonadotropin is necessary (in order to avoid testicular atrophy). Methenolone does not affect the level of bad cholesterol (LDL) and does not increase blood pressure.

Due to the low androgenic activity the cases of baldness are very rare. Despite high safety rating the following side-effects may occur: aggression, excitability, insomnia, increase of liver enzymes etc.

Dosagem e uso

Usually athletes take Primobolan for cutting cycles or to preserve muscles. Owing to mild action the length of a cycle should last up to eight weeks. However longer period may increase the risks of adverse effects.

The common doses of Oral Primolaban are 50-100mg/day. In 2-3 days after the end of a cycle you should start PCT. The usual dosage of injectable Primobolan (Depot) is 400mg/once a week. Post Cycle Therapy should begin in 3 weeks since last injection.

Consult your doctor before taking Primobolan, make sure you don’t have contraindications.

Primobolan Combinations

Because of mild anabolic effect, bodybuilders often stack it with other steroids. For muscle gains it is usually combined with :nandrolone: (probably the safest cycle), :testosterone-c:, :anadrol: or :methandrostenolone:. For cutting cycles it is combined with :winstrol:.

Do not introduce more than one steroid into your combination. Take both steroids at half-doses. This method will decrease the risks of side-effects and enhance efficiency of your cycle.