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Arimidex dosage during cycle

Arimidex (Anastrozole) is an aromatase inhibitor, an enzyme that converts testosterone to estradiol. When used with anabolic drugs, Anastrazole minimizes the side effects of estrogen.

Anastrazole controls the level of this female sex hormone, it also increases the levels of free testosterone. The drug is safe and well tolerated when correct doses are used.

  • Reduces estrogen levels
  • Increases the effectiveness of steroid hormones.
  • Promotes natural testosterone synthesis even with androgen steroids.
  • Prevents gynecomastia in men.

Pharmacodynamics

The non-steroidal active ingredient selectively blocks aromatase. In postmenopausal women, folliculin, androstenedione and aromatase promote estradiol synthesis.

With a decrease in the estradiol level, breast cancer is treated. The estradiol level is reduced by 80%. The drug has no progestogenic, estro or androgenic activity.

When the tablets are taken orally, the active substance is rapidly absorbed from the gastrointestinal tract. Its binding to plasma proteins will be 40%. Accumulation in the body does not occur. The maximum concentration in the blood will reach after 2 hours if the agent is taken on an empty stomach.

Dealkylation, hydroxylation, glucuronidation ensure the absorption of the drug by the liver. Urine and blood contain the main metabolic product, triazole. Excretion of drug metabolites is 3 days.

Benefits and harm

  • Anastrozole removes unnecessary fluid from the body.
  • It has a positive effect on blood cholesterol profile.
  • Increases libido in men.
  • Prevents arterial hypertension.
  • Decreases estrogen dependent inhibition of the pituitary-hypothalamus-testicles axis.
  • The remedy is popular for PCT during the recovery period.
  • The medicine helps well with hormone replacement therapy.

One should remember that estradiol is needed by the body for normal functioning. Therefore, it is important for an athlete to remember about biological role of estradiol and to keep it on the proper level.

 

The low estrogen levels may cause

  • Memory impairment
  • Mood changes
  • The problems with joints
  • Depression.
  • Decreased Libido.
  • The cholesterol level will rise.

 

How to take it right

The tablets are indicated for bodybuilders with experience after a cycle of anabolic steroids at maximum dosages. The medicine is used in two cases: before the cycle of anabolic steroids for prophylaxis with therapeutic doses, and after the cycle, to prevent the side effects of steroids.

The tablets should be taken on an empty stomach with a large volume of water. In this case, the active ingredient will quickly enter the bloodstream from the digestive system.

On the cycle, Anastrozole should be taken every other day during 2 weeks. The optimal dosage for good athletic performance does not exceed 250 mcg once every 2 days.  To reduce the estardiol level by half, a dose of 0.5-1 mg is recommended. For preventive measures in bodybuilding, 0.5 mg is enough every other day.

For gynecomastia 1 mg is used until the symptoms are eliminated, then 0.5 mg every other day. It is important to remember that not all anabolic steroids are aromatized. For example, in Anadrol, the transformation into estrogens is insignificant.

When using anabolic steroids with a short half-life, like Methandrostenolone, after 10 days, an analysis is made for the concentration of estradiol in the blood, Anastrozole is taken at 0.5 mg every other day. Then, after 10 days, estradiol is examined, the dose is adjusted.

When using anabolic steroids with long esters, for example, Sustanon, the dosage is 0.5 mg every other day. It is required to make a test for estradiol in 3 or 4 weeks after beginning of a cycle. The control analysis is carried out approximately in 10 or 14 days after you start taking Anastrozole. You should decrease the dosage if side effects are observed.

You should not combine Tamoxifen with Anastrozole. With such drug interactions, there is a mutual weakening of these drugs. It is forbidden to consume alcohol with Anastrozole, otherwise, with such compatibility, the pharmacological effect of the drug will not appear, undesirable consequences will appear.

 

Post cycle therapy

It is important to remember that drugs that inhibit aromatase are not used in post-cycle therapy, they are used during the cycle and after the use of anabolic steroids (before PCT).

 

During PCT, drugs that block estrogen receptors (Clomid, Tamoxifen) are taken after a cycle for 2-3 weeks. Tamoxifen requires 10-20 mg per day, or Clomid 25-50 mg per day is used. The dose is gradually reduced towards the last week.

 

Thanks to chorionic gonadotropin, testicular atrophy can be prevented. It is used for heavy cycles, the duration of which is more than 6 weeks. It is introduced on the last 4-5 weeks of the cycle and should be used until discontinuation of steroids. Then you need to switch to drugs that block estrogen receptors.

 

The use of Cabergloline is recommended during cycles with progestin drugs, due to which the prolactin level increases. The dosage is 0.25 mg every 4 days for the entire cycle.

 

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Clomid and nolvadex for pct

clomid nolvadex pct

Tamoxifen (Nolvadex) and Clomid for PCT

In this article we will try to figure out the difference between Tamoxifen and Clomid, as well as which one is better and more effective for PCT. There is a lot of disagreement on this topic and it often happens that opinions differ greatly. The correctness of the choice always ensures an effective recovery period after the cycle, and this is the most important thing on the PCT.

 

Clomiphene citrate, also known as Clomid, as well as Tamoxifen previously known as Nolvadex, belong to antiestrogenic drugs. They are almost identical in structure, and belong to the group of specific estrogen receptors modulators. Their effect is focused on blocking the hormone estrogen by intimate association with receptors. For men, both remedies prevent the feedback of estrogen hormones on the hypothalamus and cause the production of gonadoliberin. For some reason, almost all bodybuilders are sure that only Clomid is able to stimulate natural testosterone. But practice has shown that Tamoxifen does an excellent job with this task.

In the late 70s, serious research was carried out at the University of Ghent, located in Belgium, which confirmed the advantages of Nolvadex over Clomid – in terms of increasing the amount of its own hormone testosterone in the body. Scientists were interested in the result of taking drugs when they influence the functioning of the endocrine system. It was found that if you take Nolvadex for 10 days with a daily dosage of 20 mg, you can actually increase the presence of testosterone inside the serum by as much as 142%. For comparison, Clomid in this variant would need to be taken at 150 mg daily. If we consider the price of both drugs, then we will understand how profitable it is to take Nolvadex.

 

The difference of Clomid (clomiphene) and nolvadex (tamoxifen)

Clomid tends to affect estrogen receptors directly in the pituitary gland and ovaries. The drug has no effect on the amount of estrogen in the blood.

Nolvadex or Tamoxifen blocks all types of receptors. Experts call Clomid a selective blocker, while Nolvadex is indiscriminate one. In simple words, Nolvadex tends to bind to estrogen receptors located throughout the athlete’s body. Clomid effectively fights the inhibitory effect of estrogens on the normal functioning of the pituitary gland and hypothalamus. Nolvadex also allows you to restore natural testosterone in the shortest possible time.

It should be said about the disadvantages of Tamoxifen. It is quite toxic and can cause lack of appetite during the cycle, unpleasant nausea, and increases the risk of thrombosis. Since this modern drug increases the number of progesterone receptors, it is not recommended to use it along with progestogenic steroids, like Anapolone, various forms of Trenbolone and Nandrolones.

 

Conclusion

 

Why might Tamoxifen be a better choice than Clomid? There are a number of reasons for this, which we will provide below.

 

Tamoxifen can restore the required amount of the testosterone hormone in the athlete’s body, with  less critical effects on the pituitary gland than Clomid.

Tamoxifen reduces the amount of bad cholesterol, which is important for all athletes taking steroids.

Clomid has the ability to increase globulin levels, which is directly related to testosterone. This is bad for an athlete’s weight gain.

In terms of pricing, the cost advantage is again on the side of Tamoxifen, since Clomid is more expensive drug.

Common disadvantages

Both drugs have some drawbacks. When taken, they inhibit the normal functioning of the testicles, suppress the production of insulin-like growth factor, increase the level of globulin in the body (which bind sex hormones), and increases the concentration of estrogens by several times. And one more important point – you cannot take both drugs for too long

How and When to Take Nolvadex (Tamoxifen)

During a cycle of strong anabolic steroids, it is strongly recommended to use aromatase inhibitors. The most famous of them is probably Proviron, known to many athletes. It causes a slight increase of testosterone in the blood due to the inhibition of the undesirable of aromatization. Also it does not have a negative effect on the production of growth hormone.

At the final week and 2 more weeks after the cycle, it is necessary to take Tamoxifen as the main component of the PCT. If aromatase inhibitors are not used, one should start taking Nolvadex on the 2nd week of the cycle, and continue up to 2 – 3 weeks after the end of the cycle. In this case, 10 to 20 mg of the drug should be used daily.

There is no need to take aromatase inhibitors if non-aromatizable steroids are used. It is wise to introduce Tamoxifen exclusively at the end of the cycle.