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The Inner Symphony: Balancing Estrogen and Androgens in Women

The conversation about female hormones often focuses solely on estrogen and progesterone. However, this overlooks a crucial player: androgens, often labeled “male hormones.” In reality, women naturally produce androgens like testosterone, and the delicate balance between these and estrogen is fundamental to a woman’s health, vitality, and well-being.

Estrogen is the maestro of the female reproductive system, regulating the menstrual cycle, supporting pregnancy, and maintaining bone density, skin health, and cardiovascular function. It promotes the development of female secondary sex characteristics and is essential for lubricating tissues and a stable mood.

Androgens, produced in the ovaries and adrenal glands, are not antagonists to this process but vital contributors. In healthy amounts, they provide the essential building blocks for estrogen production and are responsible for:

  • Energy and Vitality: Supporting muscle strength, stamina, and overall motivation.

  • Libido: Playing a primary role in fueling sex drive and sexual responsiveness.

  • Bone Health: Contributing to the maintenance of strong, dense bones.

  • Mood Regulation: Influencing a sense of well-being and confidence.

The goal is not to eliminate androgens but to maintain their harmonious balance with estrogen. When this balance is disrupted, symptoms can arise.

  • Androgen Excess: A relative excess of androgens, often seen in conditions like Polycystic Ovary Syndrome (PCOS), can lead to symptoms such as acne, hirsutism (unwanted hair growth), hair thinning on the scalp, and irregular periods.

  • Androgen Deficiency: Conversely, low levels can contribute to a persistent lack of energy (fatigue), reduced muscle mass, a diminished sense of well-being, and a notably low libido.

  • Estrogen Dominance: This state, where estrogen is high relative to progesterone (and sometimes androgens), can cause weight gain, mood swings, bloating, and heavy periods.

This hormonal interplay is a finely tuned symphony, not a battle between opposites. Factors like stress, diet, exercise, and age can all influence this delicate equilibrium. Understanding that both estrogen and androgens are essential, complementary forces highlights the importance of a holistic approach to female health—one that seeks not to eliminate but to harmonize.

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The Delicate Dance: Understanding Estrogen and Androgen Balance in Men

When we think about hormones in men, testosterone often takes center stage. However, its often-overlooked partner, estrogen, plays an equally critical role in a complex and delicate hormonal dance. Contrary to popular belief, estrogen is not just a “female hormone”; it is essential for male health, and its balance with testosterone (an androgen) is crucial for overall well-being.

Testosterone is the primary driver of male characteristics, such as muscle mass, bone density, libido, and facial hair. But a significant portion of a man’s testosterone is naturally converted into estrogen, specifically estradiol, through a process called aromatization. This is not a flaw—it’s a vital biological function.

The key to optimal health is not maximizing testosterone and minimizing estrogen, but rather maintaining a precise balance between the two. This equilibrium supports:

  • Healthy Bone Density: Estrogen is the primary hormone responsible for closing bone growth plates and maintaining bone strength throughout a man’s life. Low estrogen levels can lead to osteoporosis and increased fracture risk.

  • Brain Function: Estrogen supports cognitive function, memory, and a positive mood. Imbalances have been linked to fatigue, irritability, and “brain fog.”

  • Cardiovascular Health: Estrogen contributes to healthy cholesterol metabolism and supports the flexibility of blood vessels.

  • Libido and Sexual Function: Both hormones are essential for a healthy sex drive. While testosterone fuels desire, estrogen helps regulate it and is necessary for achieving normal erections.

An imbalance, where either hormone is too high or too low relative to the other, can lead to issues. For example, excessively high estrogen coupled with low testosterone can contribute to weight gain, gynecomastia (development of breast tissue), and water retention. Conversely, low estrogen can weaken bones and disrupt metabolic health.

Ultimately, male hormonal health is a symphony, not a solo performance. The intricate interplay between estrogen and androgens like testosterone is fundamental to everything from physical strength and vitality to mental clarity and longevity. Acknowledging and supporting this balance is a cornerstone of truly holistic health for men.

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Anabolic Steroids: Enhancing Muscle Mass and Physical Form

Anabolic-androgenic steroids (AAS) are synthetic substances modeled after the primary male sex hormone, testosterone. Their primary function is to promote the growth of skeletal muscle and the development of male sexual characteristics, making them a powerful agent for physical transformation.

The fundamental way anabolic steroids work is by dramatically enhancing the body’s anabolic processes. They enter muscle cells and bind to androgen receptors, which directly stimulates the cell’s DNA to increase the rate of protein synthesis. This means the body builds new muscle tissue far more efficiently and rapidly than is naturally possible, leading to significant gains in muscle size and strength, a state known as a positive nitrogen balance.

Furthermore, anabolic steroids greatly increase the body’s red blood cell production. This elevates the blood’s oxygen-carrying capacity, which can drastically improve muscular endurance and recovery. This allows for more intense, frequent, and longer training sessions, which in turn contributes further to muscle hypertrophy and a faster attainment of fitness goals.

The visual results of these mechanisms are profound. Users often experience a rapid increase in lean body mass, a dramatic reduction in body fat, and enhanced muscle vascularity and definition. The overall physique becomes more muscular, denser, and leaner, projecting an image of peak physical conditioning and power.

In summary, through their potent stimulation of protein synthesis, improvement in recovery, and promotion of a lean body composition, anabolic steroids are recognized for their ability to rapidly and significantly enhance muscle mass and overall physical outlook.

You can purchase anabolic steroids at 24HoursPPC.ORG

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Human Growth Hormone and Anti-Aging: Potential Benefits

The quest to slow the visible signs of aging has led to exploring various scientific avenues, one of the most controversial being Human Growth Hormone (HGH). Naturally produced by the pituitary gland, HGH is crucial for growth, cell repair, and metabolism during youth. As we age, our HGH levels decline significantly, which has spurred interest in using synthetic HGH as an anti-aging therapy.

Proponents point to several potential advantages based on clinical studies and user reports:

Improved Body Composition: Studies have shown that HGH therapy can help decrease body fat, particularly abdominal fat, and increase lean muscle mass. This can lead to a more youthful and toned physique.

Enhanced Skin Health: HGH may contribute to thicker, more elastic skin. It can stimulate the production of collagen, reducing the appearance of wrinkles and improving overall skin texture.

Increased Energy and Stamina: Some users report a significant boost in energy levels, reduced fatigue, and an enhanced sense of overall well-being.

Better Bone Density: HGH plays a role in bone building and maintenance. For some, therapy may help improve bone mineral density, which naturally declines with age.

Mood and Cognitive Function: Anecdotal evidence suggests potential improvements in mood and cognitive function, though this is less conclusively proven by rigorous scientific studies.

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Anabolic steroids in old age

It is well known that total testosterone declines with age in men from 50-55 y. by 0.8-1.6% / year, while free testosterone starts to drop from 30-35 years at the rate of 2-3% per year. By age 70, a man’s testosterone level can drop by as much as 50 percent. The problem of testosterone decline is one of the most urgent in medicine. Today we know that males go into andropause with age, similar to the female menopause.

The reasons of this decline is in malfunction of the hypothalamus-pituitary- testicles axis (HPTA), as well as an increase in the concentration of sex hormone binding globulin.

Previously, it was believed that the role of testosterone is important only for secondary sexual characteristics, libido and in the production of sperm, but now it has been proven that this hormone affects almost all vital systems of the body. Testosterone acts on the genitourinary system, brain, muscle, bone, adipose tissue and skin cells. Recently it has been discovered that low testosterone levels increase the risk of diabetes. Besides testosterone is responsible for the blood supply to tissues, as low levels of testosterone can lead to impaired blood flow.

Clinical signs of andropause

Testosterone deficiency leads to disturbances in almost all systems and tissues. “memory is impaired, concentration of attention decreases, mental alertness is lost. The patient’s eyes seem to fade, the head and shoulders are lowered, the muscles become more sluggish, the abdomen enlarges, the chest becomes more like a woman’s. Due to the low testosterone level, the bones become fragile and skin gets thinner.

The main signs and symptoms of andropause are:

  • Genitourinary disorders:
  • decreased sex drive and erectile dysfunction
  • decreased fertility
  • frequent urination
  • Vascular disorders:
  • sudden hyperemia of the face, neck, upper body
  • hot flashes
  • fluctuations in blood pressure
  • pain in the heart
  • dizziness
  • feeling short of breath
  • Mental disorders:
  • increased irritability
  • fast fatigue
  • weakening of memory and attention
  • insomnia
  • depressive conditions
  • decrease in general health and performance
  • Somatic disorders:
  • decrease of muscle mass and strength
  • fragility of bones
  • gynecomastia
  • obesity
  • baldness
  • thinning of the skin
  • decrease in the level of total and bioavailable testosterone
  • increased levels of estradiol and sex hormone binding globulin
  • anemia
  • increased cholesterol

Age of andropause

The likelihood of andropause onset increases with age.

Age of Andropause

  • 40-49 years 2-5%
  • 50-59 years 6-40%
  • 60-69 years 20-45%
  • 70-79 years 34-70%
  • over 80 years  90%

Side effects of anabolic steroids in old age

Tumors

For older athletes, the risk of hypertension, vascular atherosclerosis, myocardial ischemia and malignant tumors (prostate, mammary glands, intestines, etc.) is much higher and increases with age. Since anabolic steroids increase the rate of cell division, it was previously believed that these drugs can increase the frequency of mutations. If in youth the number of mutant cells is lower, and the immune system is more active, the body copes with this problem. But after 40 years, the immune system weakens, the number of mutated cells begins to grow rapidly – as a result, tumors may appear. However, modern experimental data deny the carcinogenic effect of steroids, with the exception of the prostate and liver (in the case of the use of hepatotoxic 17-alkylated drugs).

Swelling and hypertrophy of the prostate

The use of 5-alpha-reductase inhibitors is highly effective in benign prostatic hyperplasia (BPH). In this regard, it has been hypothesized about the possible negative effect of exogenous androgens on the prostate gland. At the same time, it was noted that most often these diseases occur in old age, i.e. despite the decrease of androgens levels.

Numerous molecular studies have shown that the main pathogenetic factor in the development of BPH is an intracellular increase in 5-alpha-reductase activity, leading to an increase in the level of 5-alpha-dihydrotestosterone in prostate cells, and not an increased plasma testosterone level.

Thus, BPH is not considered to be a contraindication to androgen replacement therapy. Many studies have not found a correlation between plasma testosterone levels and the incidence of prostate cancer.

In the presence of prostatic hypertrophy, testosterone is used in combination with 5-alpha-reductase inhibitors (Finasteride) as hormone replacement therapy. This somewhat reduces the effectiveness of the cycle, but significantly reduces the development of androgenic side effects, including on the prostate gland. In addition, it is recommended to perform a preventive examination 2 times a year, as well as laboratory measurement of prostate specific antigen.

Alopecia (baldness)

Scalp hair loss is also associated with an increase in DHT, so combination therapy with Finasteride or Dutasteride can effectively prevent hair loss.

Suppression of testosterone secretion

As you know, with the use of androgens, it is possible to suppress the endocrine function of the testes and spermatogenesis through the mechanism of negative feedback. This effect is especially noted with long-term use of anabolic steroids in high dosages.

At the same time, intake of 240 mg of testosterone undecanoate (ANDRIOL) for 6 months was not accompanied by a decrease in the initial normal level of spermatogenesis. Other studies also did not show significant suppression of normal gonadotropin levels or endogenous testosterone with this drug, which is likely due to the short half-life of testosterone undecanoate.

Thus, adequate post-cycle therapy can eliminate this complication if andropause has not yet occurred. After the onset of andropause, continuous hormonal therapy is recommended.

Testicular atrophy

Due to the suppression of the secretion of gonadotropins by the feedback mechanism, with prolonged use of anabolic steroids, atrophy and desensitization of the testicles can develop. In other words, after discontinuation of exogenous testosterone, the testes do not restore the ability to secrete their own testosterone. Therefore, long cycles should be accompanied by gonadotropin.

Erythremia

Testosterone therapy often leads to an increase in hematocrit above physiological values ​​due to the constant stimulation of erythropoiesis (associated with increased production of erythropoietin under the influence of androgens). Most authors recommend reducing the dose of steroids when hematocrit values ​​are above 51% and discontinuation of the drug when the values ​​are more than 54%.

Atherosclerosis

A controversial issue is the effect of exogenous androgens on blood lipid levels. Traditionally, it is believed that the increased risk of atherosclerosis and coronary heart disease in men compared with women of reproductive age is associated with a negative effect of androgens on the lipid profile. However, several studies have shown that testosterone administration leads to a decrease in atherogenic VLDL and LDL levels, while anti-atherogenic HDL levels are relatively unchanged.

TRT for the elderly

The main drugs for androgen replacement therapy in men are testosterone esters. There are oral, injectable and transdermal drugs. Currently, C17-alkylated testosterone (methyltestosterone), which have toxic and carcinogenic effect on the liver when taken orally, are practically out of use. Growth hormone is gaining popularity, which is able to rejuvenate the skin, as well as strengthen joints and ligaments.

Testosterone Enanthate and Testosterone Cypionate are the most common testosterone in the United States. Thus, an adequate dosing regimen is intramuscular administration of the drug in a dose of 1 ml once every 3 weeks. Often, a replacement dose is prescribed within 3 months, followed by cancellation for up to 3 months.

New drugs

Scientists are constantly looking for more perfect drugs. Now, for example, the injectable drug Nebido appeared, which needs to be injected four times a year. The drug provides a stable concentration of testosterone for three months: due to gradual release from the “oil depot”.

Testogels and testosterone patches are gaining popularity around the world, since they need to be applied on the skin once a day.

Relatively recently, a new form of testosterone administration was created – tablet under the tongue, or plates that are attached to the gums. These methods are undergoing clinical trials.

 

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Oral turinabol

Turinabol (Turanabol) is an AAS that is similar in effects and chemical structure to methandrostenolone. Unlike methan, turinabol contains an additional chlorine atom at the fourth carbon atom. Initially it was developed by the German pharmaceutical company Jenapharm and patented in 1961.

Turinabol profile

  • Anabolic properties – 180%
  • Androgenic properties – 50%
  • Conversion into estrogen – no
  • HPTA suppression – moderate-high
  • Liver Toxicity – moderate
  • Administration – tablets
  • Half-life – 16 hours
  • Detection time – up to 250 days (due to long-living fat-soluble metabolites)

Maximum plasma concentration 3 hours after administration.

Description

The drug can be described as Methandrostenolone without water retention.

It is a slow acting steroid. During the cycle, weight, strength and relief progress very slowly, however the results are impressive.

Another feature of the drug is the absence of estrogen related side effects water retention, gynecomastia, etc

Also, it has been noted that the concentration of SHBG decreases, therefore testosterone levels in the blood go up.  There is also evidence that turinabol reduces the risk of blood clots in the blood vessels and heart.

Cycle

The regular dose with minimum side-effects is  20-40 mg / pd, which should be divided into three portions. However, bodybuilders often neglect this, bringing the dosage up to 100-150 mg per day

The drug can be used both for gaining muscle mass and for drying. Turinabol cycle does not require the inclusion of gonadotropin (if it does not exceed 6-8 weeks), however, PCT is carried out with estrogen receptor blockers (tamoxifen).

 

Turinabol solo cycle is considered one of the easiest and safest in bodybuilding, therefore it is often recommended for beginners. For the first cycle, the optimal dosage is considered to be 40 mg / day for 6 weeks. This allows you to get impressive results, both in terms of gaining high-quality muscle mass, and in the progress of speed-strength results.

For gaining muscle mass, a combined course of Turinabol (20 mg per day) + testosterone enanthate 250 mg per week (or + sustanon) is better suited. Cycle duration is 6 weeks. First, enanthate is canceled, and after a week turinabol.

Athletes who are not interested in gaining mass and strive to increase speed and endurance (boxers, wrestlers, runners, etc.) are recommended lower doses – 10-20 mg per day.

However, one should remember that today turinabol can be easily detected in doping tests due to long-lived metabolites which can be detected within six to eight months. The latest developments in gas chromatography-mass spectrometry have contributed greatly to this incredibly long detection period.

Side Effects

Turinabol is a 17-alkylated anabolic steroid that allows oral administration, which causes liver toxicity comparable to methandrostenolone. In general, side effects are quite rare and are most often associated with too long duration of a cycle and high doses. This drug strongly suppresses the secretion of its own testosterone.

Qualitative test

The presence of halogen (chlorine) in the turinabol molecule makes it possible to detect a fake even at home. There is a qualitative method for the determination of halogens in a sample – the Beilstein test.

To perform the experiment, you will need a gas burner, copper wire, and a sample to analyze. The sample is ground to a homogeneous powder. We bend the end of the copper wire, making a loop, and keep it in the burner flame until the greenish tint of the flame disappears. Next, we remove the wire from the flame, place a dry sample on the loop and put it back into the burner flame. If it turns green, the sample is positive.

 

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Gainers in sports

Gainer is a kind of sports nutrition, which contains proteins and carbs. Sometimes creatine, vitamins, amino acids and fat may be added. The major function of a gainer is to increase body weight and quickly replenish energy.

The history of gainers is quite long. In the very beginning they were made from cheap proteins, loaded with sugar and fats to maximize calories. One portion could contain up to 3000 kilocalories. The quality of proteins was quite poor.

What is it used for?

It is intended for athletes who has no problems with fat and seek to gain weight quickly. If you add three portions of gainer to your regular diet and regularly do your bodybuilding routine, then you will begin to grow steadily. For athletes with fast metabolic rate, this is sometimes not enough, so you have to include additional sports supplements and raise the calories of your daily diet. Athletes with weight problems are not recommended to take a gainer, since most of the carbs will be deposited in adipose tissue. So it is more reasonable for them to consider protein mixtures, and consume slow carbs mostly.

Also, the gainer is suitable for athletes involved in aerobic sports – boxers, runners, fighters. If you take it before training it will allow to maintain a high level of energy during it and helps to restore strength and muscles after it. Following the correct diet and weight gainer regimen, will let you easily maintain weight at the desired level. Modern gainers are good not only for gaining mass, but also as restorers.

How to take it

In bodybuilding, the best time is few minutes after training. This will allow you to quickly restore strength and energy, regenerate muscles and suppress catabolism.

You can take gainers before training as well. The high level of carbs will allow you to train harder and longer, and a high concentration of amino acids will suppress catabolism from the very beginning of training. However, there is a significant drawback – this may decrease fat burning during training, and increase the likelihood of fat deposition.

Some athletes recommend taking the gainer two, three or even four times a day. This is reasonable if you want to gain mass as quickly as possible and are not prone to fat deposition, otherwise you risk gaining mass mainly due to fat. It is more reasonable to take it 1 time a day and the remaining 2-3 doses should be protein.

Dosage and Preparation

On average, each portion contains: 20-40 g of protein, 50-80 g of carbohydrates and a few grams of unsaturated fat. The amounts of other substances vary depending on the brand of the product. Do not exceed the dosage recommended by the manufacturer, as large amounts simply will not be fully absorbed. It is quite simple to prepare gainer – a portion of dry powder is stirred in milk or water, after which it is ready for use.

Combination with other sports nutrition

The gainer works well with creatine. Carbs and proteins included in it help creatine to be absorbed better and faster. They can be mixed in one cocktail and taken after training.

In addition, to make bodybuilding as productive as possible, it is advisable to also take protein, a pre-workout complex and a vitamin-mineral complex. It goes well with anabolic complexes.

Never take a gainer during your drying and weight loss cycles.

Gainer harm and side effects

Some people ask: “How harmful is a gainer?” You should understand that it is created from natural ingredients, so it is no different from ordinary food. It is suitable for both males and females, and any age. There is a possibility of individual intolerance and indigestion, due pancreas malfunction. Also, you should remember that improper storage conditions (moisture) may cause spreading of bacteria in the product. In this case a typical food poisoning occurs. Therefore, you should keep it in dry place. Possible digestive disorder may be also linked with lactose intolerance. In case of intolerance try to reduce the dosage.

 

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Finasteride for bodybuilding

In this article we’ll discuss the role of finasteride in bodybuilding

Our body produces an enzyme called 5 – alpha – reductase. This enzyme converts Testosterone into the most powerful physiological androgen, Dihydrotestosterone. When this enzyme in normal quantities, then everything is fine, but when too much 5-alpha-reductase is produced, then steroid user begins to face such “unpleasant little things” as: baldness, increased hair growth, oily skin , excessive sweating (which smells like a real goat), acne, hyper-expressed libido and the most unpleasant thing – prostatic hypertrophy.

Finasteride is a specific, competitive inhibitor of 5 – alpha – reductase. When entering the blood plasma, it extremely quickly binds to this enzyme in the same way as Testosterone does, only in this case the conversion to DHT no longer occurs.

Actually, in the human body there are 2 types of 5 – alpha – reductase. The first is located mainly in the skin of the body and is dominant in the part of the head where hair grows. The second type is found in the tissues of the genital organs, the prostate.

So, Finasteride primarily has an affinity with the type 5 – alpha – reductase, which predominates in the genitals and the prostate gland. As for the type due to which AAS users are actively bald, then Proscar also interacts with him, but to a lesser extent.

Nevertheless, the competent use of Finasteride is really the only salvation for those whose conversion to Dihydrotestosterone exceeds reasonable limits. Therefore, this substance will at least partially stop losing hair on your head and slow down the growth of the prostate.

But first of all, you need to understand in the case of taking which specific AAS , it generally makes sense to take Finasteride. And there are actually quite a few of them, but they (with the exception of two) are the sales leaders:

  • Testosterone
  • Methandrostenolone
  • Nandrolone
  • Methyltestosterone
  • Fluoxymesterone (Halotest)

As everyone knows, if specifically, you weren’t happy to be born a pure mesomorph, then in relation to Bodybuilding and Powerlifting, any cycle without Testosterone is the road to nowhere (except perhaps the last 14-10 days of drying, when you decided to achieve direct peak dryness and muscle hardness).

With regards to Methandrostenolone, then you can do without it absolutely calmly, but for some reason most do not want to do without it. Nandrolone turns into Dihydronandrolone – a substance that is completely inert in activity both in muscles and in peripheral tissues (the same scalp and prostate), but then Dihydronandrolone can lead to a sharp disruption of neuro-muscular conduction, which on the one hand means a lack of growth muscles and strength (strength can finally fall), and on the other hand, it can provoke problems with erection. So here Finasteride is in the subject.

Methyltestosterone and Fluoxymesterone are the very exceptions discussed above. In general, it is completely pointless to suppress their androgenic side, because thanks to it they have the main effects, moreover, without conversion to DHT, they have strong androgenic activity. So there is only one piece of advice – to avoid.

The list of steroids that do not turn into DHT at all, or the degree of their conversion is scanty so much that it can be safely neglected. They do not possess noticeable androgenic activity by themselves:

  • Methenolone (Primobolan),
  • Boldenone,
  • Oxandrolone,
  • Oral Turinabol.

And finally, there is a list of steroids against which Finasteride is powerless and useless:

  • Trenbolone,
  • Oxymetholone,
  • Stanozolol,
  • Drostanolone,
  • Mesterolone (Proviron).

This article does not indicate specific schemes and doses for Finasteride, because firstly the article is not about this, and secondly, the plan should be selected individually for the person based on the results of blood tests and dosages of the AAS themselves.

Important:

Due to the ability of type II 5-alpha reductase inhibitors to suppress the conversion of testosterone to dihydrotestosterone, finasteride preparations can cause abnormalities in the development of the external genital organs in a male fetus if they are prescribed to pregnant women.

Women going to become pregnant or are pregnant should avoid contact with crushed or disintegrated finasteride tablets due to the potential for finasteride to enter the body and the subsequent potential risk to the male fetus. A small amount of finasteride has been detected in semen. In this regard, women who can potentially become pregnant or are pregnant should avoid contact with the sperm of patients taking finasteride.

Finasteride buy usa here

 

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Fat burners in sports

Fat burners are very popular in modern world. In this article we’ll talk about different types of fat burners and how they work.

Fighting excess weight is an actual problem for many people and every second visitor of the gym has the motivation “I want to lose weight”.

Sports fat burners for women and men

Strictly speaking, the name “fat burner” is incorrect. None of the approved drugs directly breaks down fat deposits.

The process of breaking down fats – lipolysis – is quite complex, and we will not describe it in detail. In short, excess body fat is processed by the body in conditions of a lack of energy from food. That is, a calorie deficit.

This means that in order to lose weight, you must spend more energy than you receive or eat less calories than you spend. From these two principles, in general, you can see how sports fat burners work – either increase energy expenditure, or block hunger or the absorption of nutrients.

Types of sports fat burners:

thermogenics

appetite suppressants

calorie blockers (fats or carbohydrates)

lipotropics

Thermogenics

Thermogenics are substances that increase body temperature, thereby increasing calorie expenditure. If you decide to purchase the occasional sports fat burner, there are likely to have nervous system stimulants such as caffeine, yohimbine, and synephrine.

Caffeine is perhaps the most familiar CNS stimulant: it is found in coffee, cocoa, tea, Coca-Cola, mate, guarana. It stimulates the release of adrenaline, which means an increase in blood pressure and body temperature. Caffeine increases endurance, allows you to concentrate on the training process and the desired result.

Yohimbine is considered the “light version” of caffeine. In terms of the mechanisms of influence on the human body, it is similar to caffeine, but initially it was used as an aphrodisiac and a remedy for erectile dysfunction. In addition, it has a mild antidepressant effect, that is, improves mood.

Synephrine is isolated from bitter oranges – oranges. But it is also found in other types of citrus fruits. Sports nutrition manufacturers present synephrine as a safe and non-toxic alternative to ephedrine, a CNS stimulant banned in most countries.

Since the mechanism of all thermogenics is approximately the same, then the side effects from them are similar. These are tachycardia, increased blood pressure, sweating, heartburn and other digestive problems, excessive agitation and anxiety. Thermogenics should not be taken in the afternoon to avoid insomnia.

In addition, tolerance develops to stimulants of the nervous system over time, it is necessary to increase the dosage, which may cause side effects. Together with physical activity, it is simply harmful to the body, especially to the heart. And with an increase in tolerance the fat burning effect decreases.

Appetite suppressants

Appetite suppressants – anorectics – act on the hunger and satiety center, allowing you to feel full from less food. Therefore you do not suffer from hunger in between meals. The most effective drug is Sibutramine, which is used to treat obesity. At one time, fluoxetine was used to suppress appetite by athletes, which, strictly speaking, belongs to antidepressants.

But both of them are prescription drugs in many countries. Other anorectics, similar in action to amphetamine, like itself, are prohibited from circulation.

It is also worth mentioning here that the line between tegmogenics and appetite suppressants is rather blurred – the center of hunger is strongly associated with serotonin and adrenaline. So, caffeine also suppresses appetite to some extent, and fluoxetine has a mild stimulating effect. This means that the side effects of anorectics will be similar to the side effects of CNS stimulants – high blood pressure, excessive nervous excitement, anxiety and insomnia, tremors and tachycardia. The danger and harm of these fat burners also lies in the fact that often people who take these drugs for a long period of time without a doctor’s supervision, eating behavior is disturbed, which leads to serious gastrointestinal diseases, insomnia and general anxiety.

Thus, appetite suppressants are not really sports fat burners for weight loss, but rather medical ones. They are used to treat obesity and strictly under the supervision of a physician.

Calorie blockers

Calorie blockers interfere with the absorption of fats and carbohydrates in the digestive tract, respectively. The enzymes lipase and amylase lose the ability to break down food and are simply removed from the body. The most popular drugs are Xenical and Metformin.

They are effective for weight loss, however they may cause stomach upset. In addition, the intake of nutrient blockers leads to a state of hunger, which interferes with an effective training process.

These drugs are taken with virtually harmless medical supervision to minimize the harm from this type of fat burner.

Fat burners effective under stress
Lipotropics are substances that stimulate the processes of fat breakdown at the cellular level. They facilitate the release of fats from deposits and transport them to the site of breakdown during exercise.

Lipotropics

Omega-3, although its fat burning effect is not the most popular among athletes. For weight loss, its ability to regulate metabolism and reduce insulin sensitivity is important.
Linoleic acid is another fatty acid involved in energy metabolism and the breakdown of body fat. Although its effectiveness is often questioned, linoleic acid can often be found in fat burning complexes.

Choline or Vitamin B4. Participates in the synthesis of acetylcholine – a neurotransmitter, ensures the functioning of the nervous system, the permeability of neurons and the required speed of nerve impulses, which is important for intense sports.

Betaine is a vitamin-like substance derived from choline. Promotes the breakdown of fats, and also increases muscle endurance. Reduces the risk of sharp pain in the liver, which appear during cardio training.

Melatonin is a sleep-regulating hormone. Its effect on weight loss is indirect, the main effect of melatonin is to normalize the rhythms of the body. Meanwhile, trainers and sports nutritionists agree that both healthy sleep and the stability of sleep and wakefulness are important for losing weight, so you should try the “sleep hormone”.

L-carnitine is perhaps the most effective sports fat burner. It accelerates the transport of fatty acids to the site of their breakdown during exercise. In addition, it has a pronounced anabolic effect, which has a beneficial effect on muscle mass. It also improves endurance and stress tolerance. L-carnitine is considered a sports fat burner for girls, as it is effective in such “typically female” sports as dancing, running and aerobics.

All lipotropics are safe fat burners, since side effects appear when the dosage is significantly exceeded. When used normally, they cause blood pressure and heart problems, fever, irritation and insomnia. Most of them have a positive effect on other human organs and systems.

The disadvantage of lipotropics is that they are effective only in combination with sports. That is, it will not work if you do nothing.

Other Slimming Drugs

Diuretics can be considered as slimming products, however, the weight loss occurs at the expense of water. And their danger is in dehydration of the body and high load on the kidneys. So these are not fat burners at all.

So what’s the best sports fat burner?

If we talk about the effectiveness and minimization of harm from side effects, then we would recommend the fat burner L-Carnitine. It not only helps you lose weight, but it also strengthens your joints, improves the functioning of the nervous system, and generally invigorates you for training. As a sports fat burner and general health supplement, L-Carnitine is equally suitable for women and men.

We would also like to remind you that for effective weight loss, it is worth paying great attention to a balanced diet and physical activity: a combination of aerobic training and strength training. A high-quality and durable result can be achieved by combined approach.

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Thymosin (TB 500) – a wonder drug for wound healing

You can buy TB-500 (Thymosin) here

TB-500 (Thymosin) is a synthetic version of a naturally occurring peptide hormone found in all types of cells. The usage of TB-500  accelerates wound healing, and exhibits a multidirectional protective effect. Recent studies have shown that Thymosin has some effect on athletic performance. For the first time Thymosin was found in thymus.

In medical practice TB-500 accelerates wound healing, and is used for restoration of myocardium after infarction, and for treatment of different types of ischemia.

As a doping it was initially used for racing horses and later on for athletes of different kind of sports. For long time it was considered undetectable in doping tests, however nowadays it is detectable by liquid chromatography.

Effects

Thymosin speeds up recovery of all types of  muscles (including heart), ligaments, joints and skin. Actually it has beneficial effect on all the tissues.

Reduces inflammation

Promotes the formation of new blood vessels in all tissues, which improves their nutrition.

Has protective effect on nervous system.

Increases production of luteinizing hormone, and testosterone accordingly.

Increases the sensitivity of tissues for insulin, which is beneficial in case of diabetes.

Improves joint mobility and elasticity of ligament

Regenerates heart muscle and reduces the risk of heart attack

Unlike popular misconception TB-500 has no significant effect on muscle growth and strength.

Thymosin Cycle

Thymosin Beta 4 cannot be taken orally, since stomach acid easily destroy it, therefore it should be injected into the muscle or under the skin. Its major application is for treatment of injuries, and as cardioprotector.

Loading phase: dose 2-6 mg a week, split into two injections (2-3 mg each: Monday, Thursday). The length of the loading phase is 4 weeks.

Supporting phase: 2-4 mg a week, split into 2 injections. Duration 4-8 weeks.

Alternative scheme: 10 mg for the 1st week (1-2 mg daily), then 5 mg a week (optimally split into two injections) for 5 weeks and a maintenance dose of 10 mg per month (2 mg every 6 days ) is optimal and effective in the opinion of many US athletes using the TB500. In total, we get 18 vials of 2 mg for the first 6 weeks + 5 vials of 2 mg for 4 weeks to maintain the results.

 

Preparation and storage of the solution

 

Cool the bottle to room temperature and introduce the required volume of water for injection (which should flow down the wall of the bottle), then stir with rotating movements (do not shake), or put it in the refrigerator for a while. It is better to use saline solution, which allows it to be frozen.

In the refrigerator, the solution remains stable for about 8 days, in the frozen state – up to a month.

Side effects

According to different studies there are no toxic or serious side effects even at a dose of 1260 mg.