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Andriol / Testosterone Undecanoate / Restandol profile: usage and stacks

Kroppsbyggare använder inte bara injicerbara testosteronestrar utan också en oral estrar (etrar) - det här är  testosteronundekanoat kända under varumärken  andriol, restandol, etc. and metyltestosteron. But now let’s talk about andriol.

This is very special drug with it’s unique advantages and disadvantages. Professional bodybuilders usually use it only in the pause between cycles but amateur bodybuilders, females and athletes too concerned with safe usage can use it in separate cycles.  Testosterone undecanoate is being converted in the body into dihydrotestosterone, which almost does not aromatize, therefore estrogen-related side effects are not an issue.

Andriol is taken orally, therefore, on the first glance, it cannot bypass the liver where all oral testosterones are being destroyed. However, pharmacologists invented following solution: testosterone undecanoate (Andriol) is being made in capsules, which contain very specific fatty acid, which makes andriol bypassing the liver and reach it’s target through lymphatic system. Unfortunately, it did not work out as planned completely. Part of substance is being absorbed through lymphatic system and converted to test as planned. Another part is moved out of the body faster than it become effective. The good thing is that the liver is not affected.

Average dosage is 6 capsules a day (and this is 240 mg/ ED); however, only 6.83% of substance actually  reach bloodstream, the rest is wasted. Furthermore, it is being moved out of the body very quickly through the kidneys. Try to imagine what happened if you inject let’s say regular testosterone suspension at a dosage 240 mg/ED (1700 mg/week)! But with andriol dosages below 240 mg/ED have very low effect, even 6 caps/day produces relatively moderate effect.

Andriol är alltså värdelös för "allvarliga" kroppsbyggare på tunga cykler och används främst för att förbättra libido under PCT (postcykelterapi) för att upprätthålla testnivån.

However, it has it’s own unique niches! Because of low testosterone release it is extremely safe and could be used by cautious athletes and females. Furthermore, it is not detectable just in one week after cycle is over thus making it a good drug when contest is coming close.

Extra fördel med Andriol är att det inte påverkar den naturliga testosteronproduktionen såvida det inte tas för lång tid och i höga doser.
Dosering och användning

Regelbunden daglig dosering av testosteronundekanoat varierar från 240 mg (6 kapsyler) till 480 mg (12 kapsyler) uppdelad på tre delar med samma tidsavstånd. Drick med vatten efter måltiden. Tugga inte.
Stapling

When used between cycles, it is good idea to combine andriol with oxandrolone (anavar). This will help to maintain testosterone level and thus libido and prevent muscle loss. Also Andriol /  anavar combo could be used as a safe standalone cycle: 240 mg of andriol / ED  plus 30-40 mg anavar / ED with possible addition of primobolan (400-600 mg/week) for ten-twelwe weeks. This is very safe combination. PCT is needed only if  included. Athletes over forty can find this very effective and safe, too.

En annan, stack är andriol 240 mg / vecka + anavar 20 mg / ED + deca 200 mg / vecka under 10-12 veckor. Vissa PCT (tamoxifen, clomid) är nödvändiga. Kortare cykel är möjlig om mer deka används (400 mg / ED).

Dessutom kan n vissa fall andriol kombineras med testosteronpropionat - detta är för personer som vill minska injektionsvolymen. Men enligt vår åsikt är detta slöseri med pengar.

Andriol är också lämplig för cykler före tävlingen.

Biverkning och PCT

Andriol är testosteroneter och androgenrelaterade biverkningar kan vara ett problem i teorin. Men på grund av svag verkan är dessa effekter så svaga att andriol kan betraktas som mycket säkert läkemedel om inte dosen är för hög. Endast doser över 400-500 mg börjar visa alla vanliga testosteronbiverkningar och påverkar naturlig hormonproduktion.

Ingen PCT (postcykelterapi) behövs under 400 mg / vecka ..

Upptäcktid

Det kan detekteras genom dopningstest endast en vecka efter användning.
Kvinnlig användning

Andriol (testosteronundekanoat) är det enda läkemedlet som kan användas av kvinnor utan någon fara. Den dagliga dosen är 120-240 mg. Det kombinerar också bra med anavar (oxandrolon) och ibland primobolan.

Till exempel kan kvinnlig idrottare göra 120 mg andriol / ED och 50 mg / vecka i fyra-sex veckor och sedan göra en paus i tre veckor och fortsätta med 50 mg / vecka tillsammans med winstrol (stanozolol) 10 mg / ED i ytterligare 4 -6 veckor. Måttlig PCT rekommenderas.

Buy cheap andriol online

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L-thyroxine (Levothyroxine Sodium, T4)

Buy Levothyroxine T4 online
T4 is pro-hormone, which your body converts into T3 at necessary rate only and thus it could be considered as much milder and safer drug than T3.

Levothyroxine sodium is an excellent fat burner since your metabolism is greatly increased while being on it. You can afford to be a little sloppier on pre-contest dieting since it will still burn fat when you are taking in a lot of calories since your metabolism is going haywire. It’s biological activity is 4-5 times less than liothyronine T3 if comparing mg to mg, however, hormonal levels remain more stable and price is also much lower. And there are some other unique advantages, which makes it very competitive with T3 such as appetite suppression, less need of sleep and increasing of physical durability (stamina), so question “which one is better” depends on your goals.Clinical pharmacology book by Goodman says: “Liothyronine is less desirable for chronic replacement therapy due to the requirement for more frequent dosing (plasma t1/2 = 0.75 days), higher cost, and transient elevations of serum T3 concentrations above the normal range. In addition, organs that express the type 2 deiodinase use the locally generated T3 in addition to plasma T3, and hence there is theoretical concern that these organs will not maintain physiological intracellular T3 levels in the absence of plasma T4”

Levothyroxine is widely used by bodybuilders and fitness addicts on pre-competition cycle in order to get relief, also used by overweighed people to reduce weight. It increases metabolism and produces general stimulating effects. However, this substance should be used wisely.

t4 dosage bodybuilding

It is recommended that levothyroxine be taken with an empty stomach approximately half an hour to an hour before meals to maximize its absorption. It is also recommended that the patient take the tablet with one glass of water to ease swallowing as well as to help the tablet dissolve for absorption. Dosages vary according the age groups and the individual condition of the patient, body weight and compliance to the medication and diet. Maximum dosage may reach 400 mcg per day but that is rare. Monitoring of the patients condition and adjustment of the dosage is periodical and necessaryMost people need to be careful to start with a low dosage, about 25 mcgs. per day and increase by about one tab of 25 mcgs every 3-5 days.

On days that you take multiple tabs, divide the tabs evenly across the day (i.e. 100 mcgs. would be 4 doses of 25 mcgs. spread evenly across the day.) Don’t take for more than 5-7 weeks at a time to keep the thyroid functioning properly. After doing a cycle of this drug, make sure you go 4 weeks (better 8 weeks or more) before doing it again as to allow normal thyroid functioning to return.

 

Cycle 1: classic

Start with 25 mcg / day of T4 and increase by 25.

Do 25 mgs of Metoprolol at the morning (this is beta-blockader, which eliminates heart overload and heartbeating). If heart rate at the afternoon is more than 70 beats/min, take 25 mgs more.

Increase daily dosage of T4 to 150-300 mcg / ED split on 3-4 equal parts. The last one should be consumed before 6 p.m. At high dosages you can increase Metapronol to 100 mg / ED (two times by 50 mg), but in fact metapronol dosage should be found  individually keeping heart rate between 60 to 70 beats / min. If heart rate is more than 80 – increase metaprolol by 25 mg, if below 60 – decrease by 25 mg.

Watch your blood pressure, it should not be higher than 140/100 mm Hg. Art. Metoprolol reduces blood pressure, too.

Length of treatment should be 4-7 weeks. Do not quit suddenly, smoothly decrease T4 dosage starting 2 weeks before the end of cycle, this will help to restart your thyroid.

In case of diarrhea – use loperamid.

Minimal gap between cycles – 4 weeks

 

Cycle 2: clenbuterol + L-thyroxin (T4) + yohimbine

When taken with clenbuterol, this is the single best fat-burning combination that is available today (with the possible exception of DNP). It also helps to make steroids more effective since it is such a good aid for protein synthesis.

This powerful combo is used in some ready-made fat-burners, however, you can save a lot of money if acquire every of these substances separately. High effectiveness of the cycle is supported by the ability of T4 (or T3) not only increase metabolism and launch fat-burn) but also increase response of the receptors responsible for clenbuterol and yohimbine.

Let’s consider ONE UNIT of this stack like following:

Clenbuterol – 40 mcg +
L-Thyroxine – 25 mcg +
Youhimbine – 5 mg (you can acquire it in sport nutrition shops. If you can’t find it – just disregard)

Recommended cycle:

Day 1-3: 1 unit
Day 4-6: 1,5 units
Day 7-9: 1 unit at the morning and 1 unit afternoon
Day 10-12: 1,5 unit
Day 13-15: 1 unit
Day 16-19: 0,5 units.
Day 20-21: 0, 25 units

Take 30 mins before breakfast with water.

After the cycle make 3 weeks rest before the new one.

In case of fever use 1-2 mg of ketotifin afternoon. For heart protection do beta-blockaders like metaprolol 100 mg split on two times/day

 

Tricky ways of usage Levothyroxine T4

Human body produces 90-110 mcg of l-thyroxine daily. For fat-burn it does not make sense to take just replacement dosages because your thyroid simply decreases production in response and you’ll come to what you started with – the same T3/T4 levels in your body. Thus you have to consume dosages, which are higher than natural. But it’s possible to cheat the gland. If you take 12-25 mcg once every three days it will not affect endogenous T4 production thus making aggregated level higher (!)

I.e. in order to encourage metabolism, optimal dosage is not replacement dosage, but a dosage, which can increase general hormone levels without affecting endogenous thyroid production! Replacement dosage may help only to the people with low thyroid production, but why take more risking toxic effects while you can use much lower dosages?

For instance, normal production is 100 mcg/daily. Patient has 80 mcg/ daily. If he takes 100 mcg / daily he’ll get back to normal, but natural thyroid production will be shut down. However, if he does 25mcg every three days, his body will still produce this very same 80 mcg thus making around 90 mcg in total. Got the idea? Anyway you should discuss this with your GP. For bodybuilding you can use the same scheme – either toy with high dosages or make just minor “tuning” with 25 mcg every three days.

This is safe way of usage, but, of course, effect is incomparable to 150-300 mcg/day. It’s advisable only for relatively small fat-burn.

 

Medical usage of T4

This medicine is a hormone replacement usually given to patients with thyroid problems, specifically, hypothyroidism. It is also given to people who have goiter or an enlarged thyroid gland.

Precautions and side effects

There are also foods and other substances that can interfere with absorption of thyroxine replacement. Avoid taking calcium and iron supplements within 4 hours of the medication and avoid taking soy products within 3 hours of the medication as these can reduce absorption of the medication. Other substances that reduce absorption are aluminium and magnesium containing antacids, simethicone or sucralfate, Cholestyramine, colestipol, Kayexalate. Other substances cause other adverse effects that may be severe. Ketamine may cause hypertension and tachycardia and Tricyclic and tetracyclic antidepressants increase its toxicity.On the other hand Lithium causes hyperthyroidism by affecting iodine metabolism of the thyroid itself and thus inhibits Synthetic levothyroxine as well. Synthetic levothyroxine may have adverse side effects like: palpitations, nervousness, headache, difficulty sleeping, insomnia, swelling of the legs and ankles, weight loss and/or increased appetite. Allergies to the medicine are unlikely, but if the patient develops a severe reaction to this drug such as difficulty breathing, shortness of breath or swelling of the face and tongue it is imperative that the patient immediately seek medical attention. Acute overdose may cause fever, hypoglycemia, heart failure, coma and unrecognized adrenal insufficiency. Acute massive overdose may be life-threatening; treatment should be symptomatic and supportive. Massive overdose may be a require beta-blockers for increased sympathomimetic activity. The side effects of overdosing appear 6 hours to 11 days after ingestion.

Prolonged use of high dosages in theory may lead to serious problems with thyroid and suppression of endogenous hormone production (fortunately, studies shows only 20% down after 3 weeks of usage). However, when used properly at recommended dosages, thyroid function restores after 3-4 weeks

Levothyroxin has adrenalin-like effects including increased heart rate and nervousness, which could be avoided by using beta-blockaders

 

Advantages of T4

  • Extremely powerful fat-burner in combination with clenbuterol
  • Increased stamina
  • Lower sides comparing to T3
  • Du kan buy Levothyroxine T4  här


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Long R3 IGF-1 (Insulin-like Growth Factor)

Buy IGF-1 uppkopplad
IGF-1 is the abbreviation for Insulin-Like Growth Factor 1. This is a naturally occurred long-chain polypeptide protein hormone and not a dangerous steroid. IGF-1 has molecular structure, which is quite similar to insulin. IGF-1 plays a vital role in childhood growth, especially bones and stimulates anabolic effects (muscle growth) in adults. IGF-1 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the body

Long R3 IGF-1 is a more potent version of IGF-1. It’s chemically altered to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min.
There are 70 inter-connected amino acids that make up a single chain of IGF-1. This hormone is produced when the liver is stimulated by human growth hormone (HGH). When levels of HGH rise in the blood, the liver responds by producing more IGF-1. These higher “bursts” spur growth and regeneration by the body’s cells, especially in muscle cells. Increases in IGF-1 levels have shown positive effects on increases in muscle strength, size, and efficiency. When you do not have enough IGF-1 in your body, whether caused by disease, malnutrition or a hormone imbalance, your growth can be stunted.

Det primära syftet med IGF-1 är att stimulera celltillväxt. Varje cell i människokroppen kan påverkas av IGF-1, men celler i muskler, brosk, ben, lever, njure, hudvävnad, lungor och nerver tenderar att påverkas mest positivt.

Products which increase IGF-1 can help improve muscularity and healing and recovery times. IGF-1 can also stimulate a decrease in body fat, an increase in lean muscle mass, improved skin tone and restful sleep. IGF-1 has also been documented to increase the rate and extent of muscle repair after injuries or strains. Not only do muscles recover more quickly, they also tend to return stronger and healthier than ever when levels of IGF-1 in the bloodstream are at their highest.

IGF-1 har också en positiv inverkan på åldringsprocessen. Det kan förhindra åldersrelaterad degeneration av muskler, hudvävnad och ben. Eftersom IGF-1-nivåer tenderar att plana ut och falla snabbt när levern inte stimuleras av HGH-produktion, är dessa fördelar störst när konsekvent höga HGH-nivåer bibehålls.

Combined with other supplements and monitored responsibly, IGF-1 can be beneficial for those individuals who suffer from stunted growth or growth hormone deficiencies as well as those individuals who strive to be in the best physical shape possible. Athletes, bodybuilders and physical competitors around the world are learning all about the benefits of IGF-1 and implementing the growth hormone into their daily regimented workouts. Whether you are an athlete yourself, or you prefer to workout more than a few times a week, IGF-1 can be beneficial for you. Even if you aren’t an athlete at all, but are looking to get as healthy and fit as possible for your own reasons, IGF-1 can be beneficial for you.

IGF-1 dosages and length of cycle

IGF-1 novices will be able to use a smaller dose than a more advanced user. For your first IGF-1 cycle, you need to remember that less is more, meaning that you don’t have to use a lot to get great results. This is not like testosterone where you need big doses for big muscles. For your first or second cycle with IGF-1, you will use 50mcg per injection day, 3 days per week (or 20-25 mcg daily), and split into two daily injections. For LONG R3 IGF-1 you can inject less frequent. for advanced users dosages may grow but never exceed 120 mcg daily.

The same is true for the length of cycle. IGF-1 effectiveness falls rapidly after prolonged use. Some users report 40 days, some 60 days, but our advice is to limit IGF-1 cycle for 4-5 weeks to get maximum effect then take rest. Some advanced users may do 50 days but only if they know what they’re doing. Too much IGF-1 will result in deregulation of IGF-1 receptors on the surface of muscle cells. This will jeopardize any gains from the injected IGF-1 since very little receptors means very little response! Time gap between cycles should be 20-40 days.

IGF-1 is also best taken either subcutaneously (preferably) or IM, having more direct effects on the body when injected. It’s also recommended to be taken during the morning/evening only (novice) or after work out only  (novice) or morning/evening plus after weight training sessions (advanced user). So advanced user makes from two to four injections daily.

IGF-1-användning

Assuming that we use the lyophilized form (dry powder) of Long R3 IGF-1, equivalent to a 1000 mcg vial, it is best prepared by using 1ml or 2ml of acetic acid. Let the acetic acid seep into the vile after removing the vacuum from the container. Then, let the mixture in the vial sit for a while. Put it in the fridge where the IGF-1 mixture can dissolve without accidentally knocking the vial or shaking its contents. Then afterwards, it’s all about diluting your Long R3 IGF-1 in NaCl or bacteriostatic water before intra-muscular or subcutaneous entry.

In most cases you have 1mg (1000mcg) bottle of substance, with 1 ml of pre-made acid. Since we want to use 25mcg for our injection, you need to use an insulin syringe (29 gauge 50 IU for easier measuring) and withdraw to the 2.5 tick mark on the syringe. Yes, that is a very, very small amount to withdraw which is why we recommend the 1/2cc or even 30 IU syringes. Now using acetic acid can be very painful, and it is almost impossible to inject such a small amount so you will now use bacteriostatic water or NaCL water to add more volume to the syringe. This will also help reduce the pain of the acid injection. After you withdraw your small 2.5 IU on the slin pin, just finish filling the syringe with the water.

But what to do if IGF-1 comes in powder and there’s no acid supplied (generic brands)?
That’s not easy subject to answer 🙁

If you dissolve in bacteriostatic water lifetime will be too short. Some users claim it’s just 2-3 days under +4C, so in this case you have to dissolve TOO small dosages, which is very difficult. However, in special acid solution it lives up to 4 weeks. Put 4 ml solution into 1 mg IGF-1. 1 mg = 1000mcg

How to prepare acid solution? You need bacteriostatic water, acetic acid, syringe 10 ml, and filter 0.22 mm or better 0.11mm

Take 1 ml 99% acetic acid then 7ml sterile water, shake well then leak out 7 ml out of total 8ml. Add 7ml of water AGAIN, so finally we receive 1,5% acetic acid solution.

Preferably put filter onto the syringe and put 4 ml of solution into 1mg IGF1 vial.

Insulin syringe has 40 IU for 1 ml (when measuring insulin and IGF). Thus 4 ml of solution contains 250 mcg per ml.

1000mcg/4mL: 31 mcg per 5 IU
40 IU = 250 mcg
20 IU = 125 mcg
10 IU = 62,5 mcg

So, if your dosage is 30 mcg utilize 5 IU, if dosage is 25 mcg, utilize ~4.5 IU

It’s not advisable to freeze liquid but if there’s no other way – do it no more than 1 time

Stacking IGF-1

The IGF-1 that’s produced from the use of fast acting Nandrolon eller Trenbolon is nothing significant when you compare to the amount that’s contained in a single 10mcg Long R3 injection. Having said that, it’s safe to inject exogenous IGF-1 while taking either one of these compounds.

IGF-1 and Human Growth Hormone?

Long R3 IGF-1 can directly stimulate muscle growth when compared to human growth hormone (HGH). This is because HGH indirectly results in growth and repair by first inducing IGF-1 release in the liver. If you don’t have to worry about IGF-1 release in the liver (because your directly injecting the IGF-1), new growth will be optimized.

Usage of IGF-1 brings more faster results than HGH because HGH acts indirectly and process is slower.

If stacking with HGH after workout you can do for example like this: 5 IU HGH then 50 mcg IGF after 20 minutes (or smaller dosages if you make more frequent injections).

Is there a benefit to using both of these substances together?

“Many research studies have shown that GH and IGF-1 act synergistically to augment the effect of either hormone taken individually. So, the greatest results will take place when effective dosages of both hormones are injected. Usually 10-20mcg of IGF-1 (post workout) and 4-8 IU HGH EOD (with breakfast and at 1 p.m.) is the ideal stack for optimal results and minimal side effects.

Medical usage

Tissue build up is one of the main features of IGF-1, so I’d say it’s of greater value. IGF-1 can genetically change muscular and cellular counts within the body; it can also enhance the body’s ability to regenerate damaged tissue. In fact, IGF-1 is now under intensive research for its potential to repair tissue in burn patients, and for its regenerative effects on AIDS patients suffering from muscular wasting. Immediate effects are, of course, impossible to observe since it takes a respectable amount of time to see any visible changes in muscular repair.

There’s no known lethal risk of administering IGF-1 to diabetic patients. In fact, IGF-1 can reduce the body’s need for insulin, and according to one short study, it can reduce insulin dependence of the body by as high as 45%. This may bring very promising results if we are allowed to study this matter further. If anyone experiences any uncomfortable side effects, stop it’s usage and see if the side effect disappear.

Side effects of IGF-1

IGF-1 is commonly known to cause feelings of fatigue. Some people feel very tired quickly when using this compound. It can, however, be looked at in a more positive light since more sleep means better growth. Other side effects include muscular stiffness, headaches, occasional nausea, and some also claim that it’s sometimes responsible for hypoglycemia or low blood sugar.

Du kan purchase Long R3 IGF-1 (Insulin-like Growth Factor) här.

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Cytomel (liothyronine sodium, triiodtironine, T3)

Det finns tre relaterade sköldkörtelhormoner som ansvarar för ämnesomsättningen - trikodid-tyronin (L-T3), L-tyroxin (L-T4) och tyrotrof hormon som ansvarar för att starta T4-produktion. Det mesta av naturlig T3 produceras inte direkt av din sköldkörtel, utan omvandlas snarare från T4-sköldkörtelhormonet. Cytomel är ett syntetiskt tillverkat liotyroninnatrium (T3) som liknar det naturliga T3-hormonet.

Cytomel (Liothyronine Sodium, L-T3)  has proven to be 4-5 times more biologically active and to take effect more quickly than levotyroxin T4. T3 has a faster onset of action as well as a shorter biological half-life, probably due to less plasma protein binding to thyroxine-binding globulin and transthyretin.

I skolmedicin Cytomel (Liothyronine Sodium) används för att behandla sköldkörtelinsufficiens (hypotyreos). Bland andra sekundära symtom är fetma, metaboliska störningar och trötthet.

T3 är inte farligt - det kommer tillfälligt att stänga av din naturliga sköldkörtelfunktion som kan orsaka en eftersläpning efter tillskott såvida du inte avsmalnar korrekt - det kommer dock att äta muskler, om du inte tar anavar, winny eller primo medan du tar den. Det är en bra stack med clen.
Cytomel T3 inom bodybuilding och fitness

Natural T3 is a regulator of the oxidative metabolism in cell’s mitochondria. Thus higher T3 level means  an increase in overall metabolic activity – your body spends more energy and burns more fat because of this. In low dosages, especially if taken along with steroids, it can even serve for certain muscle growth – due to increased metabolism. However, in high dosages it shifts towards catabolism and burns fat along with muscles.

Kroppsbyggare utnyttjar dessa egenskaper och stimulerar deras ämnesomsättning genom att ta Cytomel (Liothyronine Sodium), vilket orsakar en snabbare omvandling av kolhydrater, proteiner och fetter. Kroppsbyggare är naturligtvis särskilt intresserade av en ökad lipolys, vilket innebär ökad fettförbränning. Konkurrerande kroppsbyggare använder särskilt Cytomel (Liothyronine Sodium) under veckorna före ett mästerskap, eftersom det hjälper till att upprätthålla en extremt låg fetthalt utan att det behövs en hungerdiet. Idrottare som använder låga doser av Cytomel (Liothyronine Sodium) rapporterar att vid samtidig intag av steroider blir steroiderna mer effektiva, troligtvis som ett resultat av en snabbare omvandling av protein.

Cytomel (Liothyronine Sodium), is a good replacement for proviron on pre-competition cycles, especally for females. The over stimulated thyroid burns calories like a blast furnace. Those who combine T3 and clenbuterol receive synergetic effect especially because of better regulation of beta 2 receptors in fat tissue, which clen tends to deregulate. As a result these two compounds burn an enormous amount of fat.

Korrekt protein med hög proteinhalt är viktigt, det är önskvärt att ta icke-bulkande steroider som winstrol eller primo när man tar T3, annars kan idrottare förlora för mycket muskler, särskilt när man bantar.

En bra stack för maximala resultat under minimal tid kan vara Insulin, T3, AAS som primo eller winstrol och HGH.

 

Kvinnlig användning

Cytomel (Liothyronine Sodium) är också populärt bland kvinnliga kroppsbyggare. Eftersom kvinnor i allmänhet har långsammare ämnesomsättning än män är det extremt svårt för dem att få rätt form för en tävling med nuvarande standarder. En drastisk minskning av mat och kalorier under 1000 kalorier per dag kan ofta undvikas genom att ta Cytomel (Liothyronine Sodium). Kvinnor är utan tvekan mer benägna att få biverkningar än män men brukar komma överens med 50 mcg / dag. Ett kortvarigt intag av Cytomel (Liothyronine Sodium) i en rimlig dos är verkligen hälsosammare än en extrem hungerdiet.

 

Cytomel biverkningar

T3 ökar också tillväxthormonproduktionen (HGH), vilket inte är dåligt i sig men kan leda till ännu större muskelförbränning tillsammans med fett eftersom HGH också är en starkt lipolytisk förening, och detta är en annan mekanism genom vilken T3 kan utöva dess effekter. I fallet med T3 + HGH fristående stack kan detta vara ett problem, men att använda några anabola steroider kommer att hjälpa till med detta.

Möjliga biverkningar är: skakningar i händerna, illamående, huvudvärk, hög svett och ökad hjärtslag. Dessa negativa biverkningar kan ofta elimineras genom att tillfälligt minska den dagliga dosen.

 

Dosering och användning av Cytomel T3

När det gäller doseringen bör man vara mycket försiktig eftersom Cytomel (Liothyronine Sodium) är ett mycket starkt och mycket effektivt sköldkörtelhormon. Det är oerhört viktigt att man börjar med en låg dos och ökar den långsamt och jämnt under flera dagar. De flesta idrottare börjar med att ta en tablett på 25 mikrogram per dag och öka denna dos var tredje till fjärde dag med ytterligare en tablett. En dos högre än 100 mcg / dag är inte nödvändig och rekommenderas inte. Det rekommenderas inte att den dagliga dosen tas på en gång men delas upp i tre mindre individuella doser så att de blir mer effektiva.

Det är också viktigt att Cytomel (Liothyronine Sodium) inte tas under mer än sex eller max åtta veckor. Minst två månaders avhållsamhet från drogen måste följa. De som tar höga doser av Cytomel (Liothyronine Sodium) under lång tid löper risk att utveckla en kronisk sköldkörtelinsufficiens. Som en konsekvens kan idrottaren tvingas ta sköldkörtelmedicin under resten av sitt liv.

There are some opinions that using cytomel is absolutely safe for a long time and it’s easy to restore thyroid production afterwards.

-I quote – The horror stories of people on permanent thyroid replacement just aren’t true. …people recovering their thyroid hormone relatively quickly (within months, at most) after going off of several YEARS (!) of thyroid replacement therapy. …we can safely spend an athletic career using Cytomel 9-10 months out of the year, and just taking those few months off to normalize ourselves. Is this aggressive? Yes. Is this unsafe? NO. – end of quote-

Maybe that’s true. But maybe not. So in this 50/50 situation we would advice to stay on “cowardly” side and use T3 with all precautions until the opposite will be scientifically proven.

Det är också viktigt att dosen minskas långsamt och jämnt genom att ta färre tabletter och inte avslutas plötsligt.

De som planerar att ta Cytomel (Liothyronine Sodium) bör först rådfråga en läkare för att vara säker på att det inte finns någon hyperfunktion i sköldkörteln. Om du aldrig har använt T3 förut föreslås att du minskar din konstanta tid och ökar din ramp up-period för att avgöra din reaktion på t3 före tung användning.

Some people wait until your thyroid shuts down in a cutting cycle (as it will when on DNP , heavy ECA , clen – anything that raises the body temp high), however, it should just be part of the whole cycle, not just replacement therapy on the end when you are on low endogenous T3.

When it’s used in a bulking cycle to help absorb all the protein – never go over 50mcg / ED, better even do 25mcg / ED. For cutting cycles dosage might be higher.

T4 kan också användas med god effekt på samma sätt men naturligtvis är doserna olika - förhållandet t4: t3 är cirka 4: 1 eller 4,5: 1 så 100mcg t3 = cirka 400-450mcg t4

Common approach is to increase T3 from zero to full dosage during the fists 4-7 days and then decrease at the same rate at the end. However, thyroid shuts down rather quickly, so, in order to restart the gland after the cycle it’s better to lengthen “decrease” period, for instance you spend 5% of time of increasing dosage then 40-50% of time on max throttle then remaining time on slow and even decrease of the dosage over the weeks. With this you may come to the end of cycle with warming up thyroid and smoothly finish using of tabs.

For instance, here’s an example of 3 weeks cycle and .25 tabs

4 dagar = 1, 1,5, 2, 3 flikar
7 dagar = 4 flikar
10 dagar = 3, 3, 2, 2, 2, 1, 1, 1, .5, .5 flikar

Inlägget gjort

Nebido [Testosterone undecanoate injectable]

Testosteronundekanoat – Nebido varumärke från Bayer är inte bodybuilding utan snarare medicinsk produkt, unik genom sina egenskaper på grund av extremt lång verkan jämfört med oral testosteronundekanoat (andriol/restandol) eller androgel/testogel som ofta används för testosteronersättningsterapi. Den kommer i 4 ml ampuller, som innehåller 1000 mg testosteronundekanoat totalt. Den aktiva substansen är testosteronundekanoat 250 mg/ml (motsvarande 157,9 mg rent testosteron). Övriga innehållsämnen är bensylbensoat och raffinerad ricinolja. Nebido är en klar, gulaktig oljig vätska. Innehållet i förpackningarna är: 1 bärnstensfärgad glasampull med 4 ml lösning för injektion. Testosteron är primärt manligt könshormon. Nebido is used for treating symptoms of testosterone deficiency, also known as hypogonadism in adult men whose testes do not produce enough of it.  Nebido works by replacing or supplementing endogenous testosterone production.Low testosterone levels should be confirmed by two separate blood testosterone measurements and include following symptoms, which Nebido intends to cure: impotence, infertility, low sex drive, tiredness, depressive moods, bone loss caused by low hormone levels. In general, mild testosterone replacement therapy is advisable for men over 40, for men over 65 it’s vitally important since endogenous production becomes critically low.

Testosteronundekanoat kan också användas för andra tillstånd som bestäms av din läkare.

Dosering och användning – medicinsk och bodybuilding

Enligt tillverkaren, vanligt Nebido Doseringen är en enda 1000 mg injektion som görs var 10-14:e vecka, dvs ~4 gånger per år. Tyvärr följer många läkare det påståendet och schemat. Jag låtsas inte vara smartare än dessa läkare, men det finns inga oberoende studier som bevisat detta. Dessutom är bodybuilding en helt annan historia. Med tanke på att halveringstiden för testosteronundekanoat är 21 dagar, inom bodybuilding monthly, bi-weekly (or even weekly?) injections are advisable to maintain testosterone level stable. I’m not saying that it’s absolutely necessary to inject bi-weekly, but in general it’s much better than taking it once every 6 or even 12 weeks as stated by manufacturer. Disregarding of what ester you use – frequent injections is the best way to keep your test levels stable. Longer half life just means that you can do it less frequent comparing, for instance, to sustanon (3 shots / week) or enanthate (2 shots / week). Dosages in bodybuilding should be much higher than medical dosages, something like 1000 mg monthly, and this is one more point to use more frequent injections than stated by manufacturer. We do not advice higher dosages of nebido, if you need more effect, just use different testosterone forms.

Men om detta är ett medicinskt problem, ta testosteronundekanoat endast enligt anvisningarna. Diskutera punkten ovan med din läkare, men det slutgiltiga beslutet är upp till honom. Ta inte mer av det och ta det inte oftare än din läkare har ordinerat. Att göra det kan öka risken för biverkningar.

Nebido är endast avsett för intramuskulär injektion (helst i skinkan). Särskild försiktighet bör iakttas för att undvika injektion i ett blodkärl. Testosteronet frigörs gradvis hela tiden från behållaren till blodomloppet och förblir effektivt under mycket lång tid.

Stapling

In bodybuilding stack just as regular testosterone undecanoate (andriol /  restandol) – with other safe dugs like anavar, primobolan, etc. Stacking with stronger drugs like deca will just negate it’s very-low-side-effects advantage.

Fördelar med att använda Nebido

Testosteronersättningsterapi kan ge djupgående fysiska och/eller mentala förändringar hos patienter med lågt testosteron. Fördelarna med testosteronersättning på fysisk och sexuell funktion, energinivåer, fett- och muskelmassa, blodfetter och bentäthet hos män med lågt testosteron är väl accepterade. Därför bör man observera följande effekter med Nebido:

Ökat sexuellt intresse uppträder i allmänhet efter 3 veckor och planar ut efter 6 veckor
Ökning av erektioner och sexuell tillfredsställelse inträffar inom 6 månader
Förbättringar i livskvalitet är tydliga inom 3-4 veckor och fortsätter under en tid
Förbättring av depression eller humör noteras efter 3-6 veckor och når ett maximum efter 18-30 veckor
Gynnsamma effekter på blodfetter uppträder efter 4 veckor och når maximalt efter 6-12 månader
Förbättringar i blodsockernivåerna blir tydliga efter 3-12 månader
Förändringar i kroppssammansättning och muskelstyrka inträffar inom 12-16 veckor och stabiliseras efter 6-12 månader
Förbättringar i bentätheten visar sig efter 6 månader och fortsätter i minst 3 år
Minor changes in prostate size and a slight increase in the level of prostate-specific antigen occur with treatment, leveling off after 12 months. Any further increases may be related to normal aging rather than testosterone treatment.

Källa: Debut av effekter av testosteronbehandling och tidsperiod tills maximala effekter uppnås. Saad F, Aversa A, Isidori AM, et al. Eur J Endocrinol 2011;165(5):675-685.

Upptäcktid

Nebido kan leda till positiva resultat i drogtester. Detektionstiden är längre jämfört med orala former, tyvärr finns det ingen tillräcklig information om detta ämne.

Nebido (testosteronundekanoat) biverkningar och PCT

Behandling med höga doser av testosteronpreparat stoppar eller minskar vanligtvis spermieproduktionen, även om denna återgår till det normala efter att behandlingen upphört. Högdoserad eller långvarig administrering av testosteron ökar ibland förekomsten av vätskeretention.

Nebido är testosteroneter och androgenrelaterade biverkningar kan vara ett problem i teorin. Men på grund av mild verkan är dessa effekter så svaga att Nebido kan anses vara ett mycket säkert läkemedel om inte dosen är för hög.

Men om du observerar några östrogenrelaterade biverkningar som brösttillväxt eller kvinnliga fettavlagringar, börja använda tamoxifen. Om du leker med höga doser kan klomifen vara nödvändigt efter cykeln.

Om du är diabetiker kan det bli nödvändigt att justera ditt insulin.

 

Kvinnlig användning

Medicinsk användning av Nebido är kontraindicerat för kvinnor och får absolut inte användas till gravida eller ammande kvinnor. Vissa undantag är transsexuella kvinnor.

Tyvärr kan vi inte ge någon tillförlitlig information om detta ämne inom bodybuilding än så länge. Oral testosteronundekanoat är den enda formen av testosteron, som kan användas av kvinnor utan allvarliga biverkningar vid en daglig dos på 120-240 mg, den kombineras väl med anavar (oxandrolon) och ibland primobolan. Men med injicerbar form av testosteron undecanoate situationen är annorlunda eftersom mer testosteron levereras in i systemet (och mindre bortkastade) jämfört med oral form, så enligt vår åsikt, om den används av kvinnor bör doseringen vara lägre än med andriol.

Kontraindikationer

Nebido är inte avsett för användning till kvinnor. Nebido ska inte användas till barn och ungdomar.
Använd inte Nebido:
om du någonsin har haft androgenberoende cancer eller misstänkt cancer i prostata eller bröst
om du har eller någonsin har haft en levertumör

Innan testosteronstart måste alla patienter genomgå en detaljerad undersökning för att utesluta risken för redan existerande prostatacancer. Noggrann och regelbunden övervakning av prostatakörteln och bröstet måste utföras (detsamma gäller för all testosteronbehandling).

Tala om för din läkare om du har eller någonsin har haft: epilepsi, hjärt-, njur- eller leverproblem, migrän, tillfälliga andningsavbrott under sömnen (apné), eftersom dessa kan förvärras;
cancer, eftersom nivån av kalcium i ditt blod kan behöva testas regelbundet;
problem med blodpropp;

Om du lider av allvarlig hjärt-, lever- eller njursjukdom kan behandling med Nebido orsaka allvarliga komplikationer i form av vätskeansamling i kroppen, ibland åtföljd av (kongestiv) hjärtsvikt.

 

Missad dos av testosteronundekanoat

Om du missar en dos av detta läkemedel och ditt doseringsschema, ta den missade dosen så snart som möjligt. Men om du inte kommer ihåg det förrän nästa dos, hoppa över den missade dosen och gå tillbaka till ditt vanliga doseringsschema. Dubbla inte doser.Nebido förvaring

Förvaras oåtkomligt för barn.
Förvaras åtskilt från värme och direkt ljus i rumstemperatur.
Håll medicinen från att frysa.
Förvara inte föråldrad medicin eller medicin som inte längre behövs.

 

Buy Nebido Bayer (testosterone undecanoate)

Inlägget gjort

EPO – Erytropoietinanvändning för uthållighetsidrottare

EPO - Erytropoietin

Buy EPO (Erythropoietin) online

In this article we will describe different aspects of EPO including epo dosage for athletes
Erytropoietin (EPO)is a naturally occurring protein hormone. EPO is produced in the body by the kidneys and is used to regulate red blood cell production.  Patients suffering from anemia or chronic renal failure are legally allowed to use this form medically, it is proven that this product effectively stimulates and maintains erythropoiesis in a large percentage of patients treated. The efficiency of this drug quickly made it a ready replacement for older and less effective therapies such as Anadrol (oxymetholone) 50 or Nandrolone Decanoate. The biological activity or rHuEPO is indistinguishable from that of human erythropoietin. Some athletes have decided to take advantage of this substance as well.Nowadays, all EPO on the market is Recombinant human erythropoietin (rHuEPO). There are five erythropoiesis-stimulating agents currently available: epoetin-alpha, epoetin-beta, epoetin-omega, epoetin-delta, and darbepoetin-alpha. Both, endogenous and recombinant EPO makes body producing more red blood cells, thus increasing oxygen transmission from lungs to all systems of the body, including muscles, which results in increased stamina in performance sports. In the medicine it cures symptoms of anemia including cancer-caused.

EPO i SPORT

EPO has put a whole new spin on blood doping. No need for messy transfusions, just shoot up with EPO to increase your circulating erythrocyte mass.EPO is actually not that dangerous a product to use if it is used PROPERLY, and one’s blood is monitored. With proper blood work, and boosting to a safe level (typically max of 53-54% for elite level endurance athlete, while it’s around 40% for “normal” people) there shouldn’t be major complications. But do not cross that line.

Endurance athletes are highly attracted to EPO for the effect it has on red blood cell production. It is no secret that the practice of “blood doping” is popular with endurance sports. This procedure involves removing and storing a quantity of blood from your body, to be later replaced. By adding this stored blood before an event (by then the body has restored the lost blood volume), the athlete has a much greater number of red blood cells. The blood can therefore transport oxygen more efficiently, and the athlete is given a noticeable endurance boost. This has no doubt been the difference between winning and losing for many individuals. This procedure, however, carries with it a great number of risks. Blood is a difficult thing to store and administer, not to mention the problems that can occur with the extra cell volume. Part of these risks (besides cells volume problem)  are reduced with EPO, a drug that basically equates to “chemical blood doping”. Some studies have shown that athletes have had an 9% increase in VO2 max, 7% increase in power output, and a 5% decrease in max heart rate.

While the benefits of using erythropoietin are unquestionable, there are serious side affects that an athlete needs to consider. After injection, the blood has a higher concentration of red blood cells and a thicker viscosity. This may lead to thromboembolic events that could be fatal. I.e. if you dope more than necessary, thrombs may stop the bloodstream during the exercises and sportsmen dies. There are serious suspicions against EPO for the deaths of some top cyclists during 80s and 90s. Seizures and hypertension are also demonstrated in those athletes who are blood doping. Most athletic federations have banned this practice and a hemoglobin limit of 18.5 g/dL has been implemented.

The injection of EPO in the body is a practice that would be very beneficial to any athletes involved in endurance activities. It would allow them to carry more oxygen per unit of blood than before thus improving their performance. Who can use it? All long-distance runners (800+meters), cyclists, etc., i.e. anywhere you need high aerobic stamina. EPO also increases performance and durability of all fighters and players (football, hockey players, etc.)

In a study done by Audran, nine well-trained athletes (seven males, two females) received a 50U/kg dosage of rhEPO daily for 26 days. Tested were four triathletes, two cyclists, one rower, one swimmer, and one handball player, averaging an age of 24 years old and weight of 73kg. During treatment, significant increases in reticulocyte, EPO and sTfr concentrations and sTfr/serum protein ratios were seen by day ten, whereas hemoglobin and hematocrit levels did not clearly increase until day 14. From the results after the last rhEPO injection, reticulocyte, hemoglobin and sTfr concentrations remained above baseline values for seven days; and hematocrit levels remained above baseline up to 14 days; and EPO levels stayed above baseline for two days, as was expected due to its short half-life. Physiological tests were also done to measure the effect of rhEPO. On average, VO2max increased by 5ml/min/kg, and maximum heart rate lowered by 9 beats/min after the treatment period. In simple words – athlete can take advantage on the EPO injections effect for up to two weeks, but peak level is reached just after the last injection.

 

EPO dosage for athletes

Weekly dosage varies 50-300 IU per kilogram of body weight. By this guideline a 176 lb (80 kgs) athlete would take a maximum of 4000 U per injection. This would be done in the days/weeks prior to a competition, the peak effect hopefully reached near the day of the event. Sportsmen starts feeling results after two weeks of usage (hematocrit level increases 3-4%). Most of specialists agree that one should not use erythropoietin for more than six weeks!

We find it optimal to use following schedule: Loading phase 4500-12000 IU for week 1-3 (6000 IU in average), then keep supportive dosage 3000-4000 IU for weeks 4-6.  Weekly dosage is to be split on three equal shots.

Also one can use this formula: 20-30 IU per kg for every shot (three shots a week). Conservative approach is 4500 IU / week (3 shots x 1500 IU) with 3000 IU supportive dosage (3 shots x 1000 IU).The higher dosage is – the more effect and more risks you gain. Anyway, it depends on the personal characteristics, base levels, target goals desired. Blood tests recommended if you’re toying with higher doses.

Pre-competition protocol, low detection, 30 000 IU of substance available:
Weeks 1-3, 2000UI 3x per week
Weeks 4-6, 2x1500UI +1x 1000UI per week (so total of 4000UI per week)

Pre-competition protocol, low detection, only 15 000 IU of substance
available:
Weeks 1-3, 1500UI 3x per week
Week 4, 3x 500UI per week

Take one tab of aspirin two times a day after meal or along with milk to prevent stomach damages (milk neutralizes aspirin acids). Aspirin will decrease blood viscosity thus decreasing risks of thrombosis which could be fatal during the long race due to sweating and extreme dehydration.

In general, greater dosages of rhEPO induce a quicker response of increased erythropoiesis than lower dosages, however, they are more likely to be detectable by doping tests. If athlete is not in a rush, it’s better to make three shots a week – peak form will be achieved anyway.

Injecting EPO

EPO is sold in recombinant form (rhEPO) for injection. It usually is packaged as a lyophilized (freeze dried) powder that is reconstituted with sterile water before injection. Injections preferably to be made by thin needle with insulin syringes. Erythropoietin is to be given subcutaneously (between the skin and muscle – into the body fat) or intravenously. These two paths of administration have greatly different effects on the blood level of the drug. When given as an IV injection, peak blood levels of the drug are reached very quickly. The half-life is also short, approximately 4 or 5 hours long. When administered “SubQ”, the drug will take 12 to 18 hours to reach a peak level. Given an equal dose, this concentration will also be much lower than the intravenous method. The half-life also greatly extended, estimated to now be approximately 24 hours.

SubQ injections are to be made in the outer upper arms, front of thighs, or abdomen. If you are injecting in the abdomen, just be sure to not be too close to the umbilicus. If you’re doing some anticoagulant as well, you could still give EPO in the abdo, just not in the same site. EPO injections often burns because you inject it cold. If you can roll it between your hands a couple of minutes or let it get to room temperature, it is painless as an insulin injection.

 

Stapling EPO

Be extremely careful if you are going to use Erythropoietin (EPO) along with anabolic steroids, this can be a dangerous chem to mess with, especially with erythropoetesis-stimulating drugs like Anadrol.

Some endurance athletes may use both, EPO and winstrol during preparation for the contest, however, we have no information on the possible synergetic effects, and, most important, side effects. If anyone emails us his own winstrol + Erythropoietin (EPO) experience – this would be appreciated.

With high dosages anticoagulant therapy such as Lovenox is indicated to help reducing the risk of developing DVT, or deep vein thrombosis. For regular dosages aspirin is enough.

In practice, it is common for rhEPO injections to be accompanied with intravenous injections or oral supplementation of iron (orals are more effective). However, Iron overload may occur and lead to symptoms similar to those of genetic hemochromatosis. Folic asid and Vitamins also advisable.

Here’s possible EPO stack (weekly dosage!):  100 IU/kg of rhEPO; 25mg of iron, 25mg of folic acid; 2500mcg of Vitamin B12, lenght of treatment 10-20 days, 2-3 shots per week.

 

Dopingkontroll och EPO

Until recently, accurate testing has been difficult because the recombinant human EPO made in the lab is virtually identical to the naturally occurring form and there are no firmly established normal ranges for EPO in the body. The only previously available route to curtail cheating for sports governing bodies was to ban an athlete if the hematocrit level was too high (e.g., above 50%). Thus, in the past many athletes chose to cheat because, as long as they kept their hematocrit levels below 50%, there seemed little risk of getting caught. Of course, the other way to get caught was highlighted in the disastrous 1998 Tour de France. Several team doctors and personnel from several teams were caught red-handed with thousands of doses of EPO and other banned substances. Ultimately about 50% of the teams withdrew from the race – either for cheating or in protest.

Unfortunately, testing technology has now notably improved. There are now accurate urine and blood tests that can detect the differences between normal and synthetic EPO. This test became the standard one and was the sole means to detect for EPO use in the 2004 Athens Olympic Games. The reliability of this test helps explain the cascade of athletes who have been caught. Therefore, at the present, athlete must consider “window” – just like with steroid use – when chances to detect falls down, but effect is still considerable. I.e. at the moment of competition, EPO should move out of the system but red blood cells should be still in.

There are short-acting and long-acting types of EPO (we offer short-acting version). It’s better to take smaller doses on regular basis than single big injection. This reduces the possibility of detection by the urine test by lowering the percent of basic isoforms  in the urine. A smaller dose means a drug tester might only have 12 hours to detect the last injection, and given the fact that drug tests aren’t usually carried out in the middle of the night, this leaves only a very small window open for being tested “positive”. Taking small, regular doses also simulates the body’s natural physiology more closely than a super-sized dose, which means that it could even get under the radar for the longer term blood testing.  So 2000 IU three times a week is better than 6000 IU once a week.

Detection time varies 12-48 hours according to different sources (in fact you might be in danger even longer with high dosages). Most likely it also highly depends on the  dosage and cycle schedule. Fortunately, rhEPO has a short half-life and is similar in structure to endogenous EPO. These two factors make blood and urine detection difficult since electrophoretic techniques must be done within a limited timeframe in order to be able to distinguish between the two forms of erythropoietin.

So, what is this test? It is possible to detect rhEPO in urine and blood serum as was done by Wide. He tested 15 healthy, moderately-trained men between the ages of 19 to 40 years old. At a fairly low dosage, 20U/kg three times a week for eight weeks, rhEPO was accurately detected in blood up to two days after the last injection; and in urine one day after the last injection. From the data, sensitivity of the test decreases to fifty percent in detecting rhEPO in blood or urine after three days from the last injection

In order to gain the physiological effects of rhEPO, athletes need to continue its use until a late stage of preparation for an event. A test for increased erythropoiesis in the two to six weeks before competition would have a high likelihood of detecting rhEPO abuse – they can catch you during preparation.

 

Risks and side effects with EPO

Just like with steroids – you should use it wisely. Inappropriate usage might be dangerous if not fatal, but proper one eliminates all the risks or lowers it to the affordable level. Nowadays, we gained enough experience and stats to know how to avoid the problems.

The reason that EPO, and transfusion blood doping, might be dangerous is because of increased blood viscosity. Basically, whole blood consists of red blood cells and plasma (water, proteins, etc.). The percentage of whole blood that is occupied by the red blood cells is referred to as, the hematocrit. A low hematocrit means dilute (thin) blood, and a high hematocrit mean concentrated (thick) blood. Above a certain hematocrit level whole blood can sludge and clog capillaries. If this happens in the brain it results in a stroke. In the heart, a heart attack. Unfortunately, this has happened to several elite athletes who have used EPO in 80es.

EPO use is especially dangerous to athletes who exercise over prolonged periods. A well-conditioned endurance athlete is more dehydration resistant than a sedentary individual. The body accomplishes this by several methods, but one key component is to “hold on” to more water at rest. Circulating whole blood is one location in which this occurs and, thus, can function as a water reservoir. During demanding exercise, as fluid losses mount, water is shifted out of the blood stream (hematocrit rises). If one is already starting with an artificially elevated hematocrit then you can begin to see the problem – it is a short trip to the critical “sludge zone” (so drink enough liquids and don’t forget about aspirin!).

Additional dangers of EPO include sudden death during sleep, which has killed approximately 18 pro cyclists in the past fifteen years, and the development of antibodies directed against EPO. In this later circumstance the individual develops anemia as a result of the body’s reaction against repeated EPO injections (so do not use for longer than 6 weeks! and do not use through the whole year, do it 1-2 times before the most important competitions).

There are also a number of side effects associated with general use of this substance. Most notable, blood pressure can begin to rise as cell volume changes. This can reach the point of headaches and high blood pressure, obviously an unwanted effect. Additionally, flu-like symptoms, aching bones, chills and injection site irritations are also possible. Since athletes are not using this product for a medical condition, a strong incidence of side effects should be an indicator to discontinue using the drug. Clearly one should not wish to compromise their health for an athletic push.

 

Does EPO contain blood fractions?

While erythropoietin itself is not a blood product, some brands of the synthetic form do have a very small amount of a blood fraction added to them. The epoetin-alfa formulation (Epogen®, Procrit®) contains 2.5 mg human serum albumin. The albumin first prevents the pharmaceutical from sticking to the vial, and then acts as a carrier molecule to help the EPO remain in the bloodstream until it reaches its destination at the bone marrow.

 

Pharmacology

Stimulates RBC (red blood cells) production.
Pharmacokinetics
Absorption

T max is 5 to 24 hours (subcutaneous).
Elimination

Elimination half-life is approximately 4 to 13 hours (IV).

 

Special Populations

Elderly: Pharmacokinetic data indicate no apparent difference in half-life among adult patients older or younger than 65 yr of age.
Children: Pharmacokinetic profile in children and adolescents is similar to that of adults. Limited data are available for neonates.

 

What alternatives to EPO are there?

EPO is the standard of care for many patients with anemia of end-stage renal disease (ESRD). For certain patients, such as those who produce antibodies to erythropoietin, who develop pure red cell aplasia (PRCA), or who develop arterial hypertension, treatment with any form of EPO is not appropriate. However, these patients may be given androgens (hormones) that have been shown to stimulate bone marrow function. Of course, as with any medicine, these substances are not without side effects of their own. One of the most widely used of these is nandrolone decanoate (NAND), which seems to be better tolerated with less dramatic side effects than other androgenics.

In some cases, intravenous iron without EPO appears to be as effective in correcting anemia.

 

Medical Indications and Usage

Below we’ll provide some information for medical EPO (erythropoietin) usage. Please use this for information purposes only! We can give advices in sport, but not with life-threatening deceases. We do not to harm anybody by improper advice, make sure to contact your GP before usage!!!

So, where it is used in medicine? Treatment of anemia related to chronic renal failure (CRF), anemia related to zidovudine therapy in HIV-infected patients, and anemia due to chemotherapy in patients with metastatic non-myeloid malignancies; reduction of allergenic blood transfusions in surgery patients.

Kidney disease patients : Recombinant human erythropoietin was first approved as an adjunct in the treatment of kidney disease patients on hemodialysis, in whom anemia is an inevitability due to both the disease and the dialysis.
AIDS patients : Approval was also given for it to be given to AIDS patients on AZT (ziduvidene).
Red cell production : Its use is increasing in preoperative and postoperative settings to stimulate the surgical patient’s red cell production.
Acute surgical and post-op : It may be of benefit in acute surgical settings, and may permit more rapid recovery in the post-op period. In particular, it may be a useful adjunct following perioperative hemodilution.
Chemotherapy : It is also gaining currency in the treatment of anemia secondary to chemotherapy for cancer.
Blood transfusion alternative : In many clinical settings EPO may be used to reduce or even eliminate the need for blood transfusion. It can be used in neonates for treatment of anemia of prematurity. Various clinical applications for EPO and a succinct historical perspective of erythropoietin are presented and discussed in research by T. Ng, et al. (2003).
Other potential benefits : There is evidence to show that, in addition to boosting RBC production, EPO may have a positive effect on platelet and leukocyte production. EPO has also demonstrated a tissue-protective ability, of particular benefit in chronic heart failure and neurological damage, and may benefit surgical and burn patients through its wound healing properties.
Unlabeled Uses: Anemia associated with critically ill patients, CHF, chronic disease (eg, rheumatoid arthritis), postpartum anemia, sickle cell disease, thalassemia, multiple myeloma, Jehovah’s witnesses (due to prohibition of human blood transfusion), radiation treatment, epidermolysis bullosa, porphyria, for athletic enhancement (yes, that’s our case!), sexual dysfunction, transfusion iron overload, uremic pruritus.
Contraindications: Hypersensitivity to mammalian cell–derived products or human albumin; uncontrolled hypertension.

 

Medical Dosage and Administration of EPO

The optimal dosing regimen has yet to be defined. The authors of some studies favor lower doses such as 75 to 150 IU for every kilogram (u/kg) of body weight given daily or every other day. Others found that 600 u/kg given once a week was more effective. Nevertheless, the most commonly ordered dose is likely to be 300 u/kg three or four times a week. Thus, for a 70 kg patient, 60,000 IU per week would be ordered.

 

Cancer Patients EPO usage

Vuxna

Subcutaneous 3 times/wk dosing: 150 units/kg 3 times/wk. Reduce the dose by 25% when Hgb reaches a level needed to avoid transfusion or increases more than 1 g/dL in any 2-wk period. Withhold the dose when Hgb exceeds a level needed to avoid transfusion and restart at 25% below the previous dose when the Hgb approaches a level where transfusions may be required. Increase the dosage to 300 units/kg 3 times/wk if the response is not satisfactory after 4 wk to achieve and maintain the lowest Hgb levels sufficient to avoid the need for RBC transfusion and not to exceed the upper safety limit of 12 g/dL. Discontinue if after 8 wk there is no response as measured by Hgb levels or if transfusions are still required. Weekly dosing: 40,000 units/wk. Reduce the dose by 25% when the Hgb reaches a level needed to avoid transfusion or increases more than 1 g/dL in any 2-wk period. Withhold the dose if the Hgb exceeds a level needed to avoid transfusion and restart at 25% below the previous dose when the Hgb approaches a level where transfusion may be required. Increase the dosage to 60,000 units/wk if the response is not satisfactory (no increase in Hgb by at least 1 g/dL after 4 wk of therapy, in the absence of an RBC transfusion) to achieve and maintain the lowest Hgb levels sufficient to avoid the need for RBC transfusion and not to exceed the upper safety limit of 12 g/dL. Discontinue if after 8 wk there is no response as measured by Hgb levels or if transfusions are still required.
Children

IV Weekly dosing: 600 units/kg/wk (max, 40,000 units/wk). Reduce the dose by 25% when the Hgb reaches a level needed to avoid transfusion or increases more than 1 g/dL in any 2-wk period. Withhold the dose if the Hgb exceeds a level needed to avoid transfusion and restart at 25% below the previous dose when the Hgb approaches a level where transfusion may be required. Increase the dosage to 900 units/kg/wk (max, 60,000 units/wk) if the response is not satisfactory (no increase in Hgb by at least 1 g/dL after 4 wk of therapy, in the absence of a RBC transfusion) to achieve and maintain the lowest Hgb levels sufficient to avoid the need for RBC transfusion and not to exceed the upper safety limit of 12 g/dL. Discontinue if after 8 wk there is no response as measured by Hgb levels or if transfusions are still required.
CRF EPO usage
Vuxna

IV / Subcutaneous Individually titrate to achieve and maintain Hgb levels between 10 and 12 g/dL. Increases in dose should not be made more often than once monthly. Start with 50 to 100 units/kg 3 times/wk. Increase the dose by 25% if the Hgb is less than 10 g/dL and has not increased by 1 g/dL after 4 wk of therapy or if the Hgb decreases below 10 g/dL. Reduce the dose by 25% when the Hgb approaches 12 g/dL or the Hgb increases by more then 1 g/dL in any 2-wk period. If the Hgb continues to increase, temporarily withhold the dose until the Hgb begins to decrease, then reinitiate treatment at a dose approximately 25% below the previous dose.
Children

IV / Subcutaneous Individually titrate to achieve and maintain Hgb levels between 10 and 12 g/dL. Increases in dose should not be made more often than once monthly. Start with 50 units/kg 3 times/wk. Increase the dose by 25% if the Hgb is less than 10 g/dL and has not increased by 1 g/dL after 4 wk of therapy or if the Hgb decreases below 10 g/dL. Reduce the dose by 25% if Hgb approaches 12 g/dL or the Hgb increases by more then 1 g/dL in any 2-wk period. If the Hgb continues to increase, temporarily withhold the dose until the Hgb begins to decrease, then reinitiate treatment at a dose approximately 25% below the previous dose.
Surgery EPO usage
Vuxna

Subcutaneous Prior to starting treatment, obtain Hgb to establish that it is more than 10 to less than 13 g/dL.

Usual dosage: 300 units/kg/day for 10 days before surgery, on the day of surgery, and for 4 days after surgery.

Alternative dose schedule: Subcutaneous 600 units/kg in once-weekly doses (21, 14, and 7 days before surgery), plus a fourth dose on the day of surgery.
EPO usage on Zidovudine-Treated, HIV-Infected Patients
Vuxna

IV / Subcutaneous Prior to starting therapy, determine the endogenous serum erythropoietin level. Evidence suggests that patients receiving zidovudine with endogenous serum erythropoietin levels more than 500 milliunits/mL are unlikely to respond to epoetin alfa therapy. Titrate the epoetin alfa dosage to achieve and maintain the lowest Hgb level sufficient to avoid the need for blood transfusion and not to exceed the upper safety limit of 12 g/dL. For patients with serum erythropoietin levels of 500 milliunits/mL or less who are receiving zidovudine 4,200 mg/wk or less, the recommended starting dosage is epoetin alfa 100 units/kg 3 times/wk for 8 wk. Monitor the Hgb weekly. If the response is not satisfactory in terms of reducing transfusion requirement or increasing Hgb after 8 wk of therapy, the dosage of epoetin alfa can be increased by 50 to 100 units/kg 3 times/wk. Thereafter, evaluate the response every 4 to 8 wk and adjust the dose accordingly, in 50 to 100 units/kg increments 3 times/wk, to a dosage of epoetin alfa 300 units/kg 3 times/wk. After attaining the desired response, titrate the epoetin alfa dose to maintain the response. If the Hgb exceeds the upper safety limit of 12 g/dL, stop until the Hgb drops below 11 g/dL. Reduce by 25% when treatment is resumed and titrated to maintain the desired Hgb.

 

General Medical Advice on EPO

For subcutaneous or IV bolus administration only. Not for intradermal, IM, or intra-arterial administration. IV route recommended for patients on hemodialysis.

Do not shake or vigorously agitate vial. Prolonged vigorous shaking may denature the glycoprotein, rendering it biologically inactive.

Do not administer if particulate matter, cloudiness, or discoloration is noted.

If transferring saturation is less than 20%, give supplemental iron.

IV dose may be administered into venous line at end of dialysis procedure to obviate need for additional venous access.

Rotate subcutaneous injection sites.

Single-dose vials contain no preservative. Use only 1 dose/vial. Do not reenter vial. Discard any unused portion. Do not combine unused portions or save unused portions for later use.

Do not administer in conjunction with other drug solutions. However, at time of subcutaneous administration, single-use vials may be admixed in a syringe with bacteriostatic sodium chloride 0.9% with benzyl alcohol 0.9% at a 1:1 ratio. Multidose vials contain benzyl alcohol and admixing is not necessary.

Adjust dose to achieve and maintain lowest Hgb level sufficient to avoid the need for RBC transfusion and not to exceed 12 g/dL.

Storage/Stability: Store vials in refrigerator (36° to 46°F). Do not freeze or shake. Protect from light. Multidose vials may be stored in refrigerator at 36° to 46°F for up to 21 days after initial entry.

Buy EPO (Erythropoietin) online

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Proviron (DHT, Masterlone, Masterolone, Mesterolone)

Proviron (Masterolone) är en oral form av 1-metylerad DHT (metyl-dihydrotestosteron). Detta är mycket starkt androgen som är 3-4 gånger mer effektivt än "normalt" testosteron, det har inga anabola egenskaper och ingen förmåga att omvandla till östrogen. Man skulle då kunna föreställa sig att mesterolone skulle vara ett perfekt läkemedel för att öka styrkan och uppnå vissa framsteg. Tyvärr finns det en kontrollmekanism för DHT i kroppen. När nivåerna blir för höga omvandlas den till en inaktiv förening. Denna inaktiva förening kan också omvandlas i motsatt riktning till dihydrotestosteron av samma enzym när låga nivåer av DHT detekteras. Men detta betyder att mycket stora mängder av detta ämne är värdelösa för att uppnå muskelhypertrofi. Mycket vanlig användning är att bekämpa östrogen precis som med Tamoxifen Citrate eller Clomiphen. Provironhar fyra distinkta tillämpningar inom bodybuilding.För det första, proviron fungerar som anti-östrogen, det förhindrar aromatisering av andra steroider som en process och blockerar också delvis östrogenreceptorer. I detta fall skiljer sig dess verkan från tamoxifen, som bara blockerar östrogenreceptorer. Således elimineras biverkningar som gynekomasti och ökad vätskeretention framgångsrikt. Proviron träffar roten till problemet, medan Tamoxifen bara bekämpar symtom och bör användas under längre tid tills alla överdrivna östrogener tvättas ut ur kroppen.
Den andra applikationen är baserad på att utöka kapaciteten hos testosteron. 97-98% av testosteron i kroppen hos en frisk person är inaktiv och bunden till vissa proteiner. Proviron i det här fallet ersätter testosteron, så att mer av det senare släpps ut i blodet och hjälper till att bygga muskelmassa.

För det tredje tillsätts mesterolone i cykler före tävling för att öka styvheten och kvalitetsmuskelvolymen. Det minskar också vattenretention i kroppen, vilket ger användaren en visuell effekt av torra, högkvalitativa, magra muskler. Proviron används ofta inte bara bland kroppsbyggare, utan även skådespelare och modeller, som använder det för att skaffa den nödvändiga sportiga formen innan skjutningen. Precis som den andra metylerade DHT-strukturen som kallas drostanolon, är mesterolon särskilt stark för att uppnå denna effekt.Slutligen används Proviron för återhämtning av sexuell aktivitet under cyklerna av steroider som trenbolon och nandrolon, som minskar libido. Proviron ordineras också ofta av läkare för personer med låga nivåer av testosteron eller patienter med kronisk impotens. Mesterolon föredras av många idrottare eftersom det praktiskt taget inte har några biverkningar på män. I stora doser kan det orsaka vissa viriliseringssymtom hos kvinnor. Doser på 25 och 250 mg per dag ska appliceras utan negativa effekter. 50 mg per dag är vanligtvis tillräckligt för att nå målen för någon av fyra applikationer som vi nämnde ovan. Det finns alltså inget behov av att öka dosen.

Manliga idrottare bör föredra Proviron framför Nolvadex. Med Proviron uppnår idrottaren bättre muskelhårdhet, eftersom androgenhalten ökar och koncentrationen av östrogen förblir låg. Detta är särskilt tydligt när man förbereder sig för en tävling i samband med kost.

Man bör dock vara medveten om att förlusten av styrka orsakad av minskad naturlig produktion av testosteron efter cykeln inte botas. Idrottsman bör använda andra droger som HCG och clomiphen för det.

Dosering och användning

Proviron är mycket effektiv förening, daglig dos på 50 mg räcker även om vissa män gör 100 och till och med 250 mg / dag. Idrottsman tar normalt en 25 mg tablett på morgonen - och den andra på kvällen. I vissa fall räcker det med en tablett på 25 mg. Kombination av 50 mg Proviron per dag och 20 mg Nolvadex per dag resulterar i nästan fullständig dämpning av östrogen. Men kom ihåg att östrogen inte är absolut ondt, det spelar också en viktig roll för muskeluppbyggnad. Fullständig dämpning av östrogen innebär lägre vinster, så man bör hålla en balans och sänka östrogennivån bara till den punkt när det inte ger några biverkningar men ändå ger positiva.

Tidigare använde idrottare det under hela säsongen för att få en torr och vältränad utsikt hela tiden, men vi rekommenderar inte sådana övningar nuförtiden. Clenbuterol / albuterol (ventolin) kan göra samma sak men med mindre biverkningar.

Stapling

Proviron är en oral 1-alfa-alkylerad substans som oftast används som ett antiöstrogenläkemedel. Mesterolone kan faktiskt bidra till vinster. Det tas dagligen i doser på 50-100 mg.

Den bästa stacken är definitivt med testosteron. Detta resulterar i kvalitativa, magra vinster eftersom fritt testosteronnivåer ökar och mindre omvandlas till östrogen.

Naturligtvis används proviron också i många andra stackar, till exempel med dianabol (methandrostenolone), boldenone undecanoate och nandrolone för att minska östrogenrelaterade aktiviteter ökar muskelhårdheten.

Kombination av proviron med boldenone gör dead lock för en skärstack. Ibland har det till och med blivit möjligt att lägga till deca i den skärstapeln, helst tillsammans med winstrol. Det är bra att använda proviron med nandrolon, eftersom nandrolon tillfälligt minskar libido.

Detekteringstider

2 månader

Biverkningar med proviron

När idrottare gör det i mer än 10-12 veckor kan det öka levervärdena något, även om det i allmänhet proviron tolereras väl av det. Biverkningar av Proviron för män med en dos på 2 – 3 tabletter är mycket små, så att Proviron i kombination med en steroidcykel kan vara relativt säker att tas under flera veckor.

DHT kan öka blodtrycket. Höga doser kan leda till för tidig skallighet och sexuell överstimulering, vilket leder till förlängd erektion. Eftersom detta tillstånd är smärtsamt och kan orsaka penisskada, är det vettigt att minska dosen eller avbryta användningen helt.

Endast 34% av mottagarna observerar en mindre minskning av de endokrina körtlarnas funktion. Proviron slutade inte arbeta med HPTA (körtlar) för ingen som tog läkemedlet under ett år i en dos på 150 mg / dag. I allmänhet är det ganska säkert och har liten inverkan på HPTA:s arbete.

Det finns ingen effekt på frekvensen LH (luteiniserande hormon) och FSH (stimulerande hormon) vid en dos av 100-150 mg / dag.

Proviron ersätter inte Clomid som hormonbehandling, men orsakar inte problem också.

Effekten av mesterolon ger inga förändringar i nivåerna av steroider, sköldkörtelhormoner, gonadotropiner och prolaktin.

Kvinnlig användning

Kvinnliga idrottare bör vara försiktiga när de använder Proviron, eftersom det inte utesluter alla möjliga androgena biverkningar. Kvinnor rekommenderas att inte ta mer än en 25 mg tablett / dag. Högre doser och långvarig användning i mer än 4 veckor ökar risken för virilisering. Kvinnliga idrottare som inte har problem med Proviron, uppnår bra resultat genom att ta 25 mg Proviron per dag och 20 mg Nolvadex per dag. De säger att det i kombination med en diet accelererar fettförbränning och snabb härdning av musklerna.

Kvinnliga idrottare som naturligt har högre östrogennivåer lägger ofta till Proviron till steroidcykeln, vilket resulterar i ökad muskeltäthet. Tidigare gjorde kvinnliga idrottare proviron hela året för att se magra ut, särskilt före tävlingar och huvudroller. Nuförtiden gör clenbuterol / albuterol samma arbete, eftersom de inte orsakar viriliseringseffekter.

Du kan köpa billigt Proviron (Masterolone, dihydrotestosteron) uppkopplad här.

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Oral Turanabol (Turanol, Turinabol, Klordehydrometyl-testosteron)

Androgenic effect of the drug in pretty poor (6 out of 100), but in combination with anabolic effect (54 out of 100), Turanabol (Turinabol) becomes extremely effective drug. For instance, dianabol has androgenic effect 43/100 and anabolic effect 90/100, but, in turn, dianabol has much more side effects and unacceptable for performance sportsmen such as runners or cyclists. With Turanabol you won’t have problems with enlarged breasts, excessive estrogen or watery, puffy outlook like with dianabol.

The drug turinabol (turanabol) was invented in Eastern Germany and was first used in medical practice in 1965. A year later it was fully applied in the sport. At the beginning the users were only men, but since 1968 a new drug was introduced for the preparation of females. The use of oral Turinabol has been thoroughly documented. A secret document dated 1973 indicates that the outcome for women in the shot put increased by about two meters (!) due to the using of only two oral turinabol tabs (10 mg/tab) daily for 11 weeks. The results were raising along with dosage and duration of use. In 1972 oral turinabol usage in Eastern Germany spread over many other sports  where speed and strength were needed besides athletics, where it was initially introduced.

Here is a small table, which clearly shows oral turinabol effects on improving the results of the athletes.

Men / Women
Shot put 2,5-4 m / 4,5-5 m
Discus Throw 10-12 m / 11-20 m
Hammer Throw 6-10 m
Javelin 8-15 m
Running at 400 m 4-5 sec
Running at 800 m 5-10 sec
Running at 1,500 m 7-10 sec

Impressive, isn’t it?

Turanabol – What is it?

Oral turinabol is actually a version of methandrostenolone with extra chlorine atom in the fourth position. Hence the official name of turinabol is  4-chloro-alpha-Dihydromethyltestosteron. This upgrade has made the drug practically non-aromatized. Even more, turinabol metabolites very quickly leave the body, making huge advantage against the threat of doping tests.

Like the vast majority of oral AAS oral turinabol is 17-alpha alkylated, thus is potentially harmful to the liver. However, negative impact on the liver was not reported even after prolonged use.

Oral turinabol sufficiently resembles methandrostenolone not only on the structure of the molecule but the action of both drugs is also very similar. Turinabol produces less gains, but this is “quality”, lean mass and also it produces less side effects. Despite turinabol does not aromatize and is quite mild drug, prolonged usage may cause the suppression of secretion of endogenous testosterone but at much lesser extent comparing to methandrostenolone (dianabol) and it’s easily rejuvenated.

Oral turinabol and injectable turinabol in bodybuilding

The difference between oral and injectable turinabol is like with most of other steroids. Oral is easier to take but in theory it may be harmful to the liver, so one can sustain higher dosages of injectable version. Furthermore, injectable is slightly more detected. But, in general, this is a matter of personal preferences.

In bodybuilding turinabol can be called a rookie. Not surprising – in the past “pharmacological king” in Eastern Europe used to be relatively cheap methandrostenolone (dianabol). All turinabol smuggled from Eastern Germany was captured by light athletics coaches. Western Europe and USA even did not know that such product exists, at least no bodybuilders reported they ever used it. Situation changed not that long ago when this very useful drug has been given a second chance and had a stunning success on US market and short after that in all other countries.

What are the reasons of this success? At-first turinabol notably raises power. Secondly, as has been said, oral turinabol quickly leaves the body and not found in the urine within 6-8 days after end of usage. We have not heard about any positive doping tests for turinabol. However, it may be because such tests are simply not being made nowadays.

A positive feature of the drug can be considered as giving hardness to the muscles without any significant accumulation of water. Experience shows that using of turinabol is almost mandatory in contest preparation stacks. Also it copes with the task of protection of muscle mass against destruction after bulking cycles.

There is another feature of turinabol – it’s a «sex drug». This steroid fairly rapidly increase libido for men, sometimes too much, so desire of sex prevail over desire for trainings 🙂  This property, as well as the ability just slightly inhibit the production of endogenous testosterone, makes it useful drug to take in moderate doses between the cycles of “heavy” AAS to maintain sex-drive.

Dosering och användning

Turanabol is mostly used to build  lean body mass and strength without water retention, which often occurs with Daianabol and testosterone. The results with Turanabol straightly depends on the daily dosage, which normally varies between 20 to 100 mg. Athletes below 90 kgs experience no side effects at 20 mg daily and more heavy athletes easily adopt 40 – 50 mg daily.

When administered 50 mg / ED it significantly increases dry muscle mass, strength, and all of this without water retention, which can cause serious side effects due to estrogenic activity. Because of these characteristics, Turanabol is very effective product for powerlifters. In order to increase the results at the end of the course it is recommended to combine this drug with Parabolan (200 mg every week) or with Stanozolol (150 mg every week). This is very good pre-competition combo as well. The above combination allows us to construct a relief and build muscle without any additional fat-burners and guaranteed against side effects such as gynecomastia, and excessive estrogen.

In light athletics dosage is following: body weight in pounds divided by 10. For bodybuilders dosage is: body weight in kilograms divided by 1.5-2 (normally it’s 1.5 times more than your daily dianabol dosage).

Product could be applied once a day in the morning or split on two applications – morning and evening.

Stapling

It’s good for performance sportsmen, powerlifters or bodybuilders on cutting stacks. But if serious fat-burn needed, it won’t help because it’s a steroid, not pure fat-burner.

1) Turanabol 35 mg/ ED for three weeks at the end of deca-dianabol-testosterone cycle to make a relief

2) Turanabol 50 mg / ED for 6 weeks with Parabolan (200 mg / w) and / or Stanozolol (150 mg /w) at the end of cycle for 2-3 weeks (possibly from the beginning of cycle)

3) Turanabol standalone cycle 50 mg/ED for 6 weeks. Lean mass / pre-competition stack.

4) During preparation stacks turinabol is often combined with trenbolone, oxandrolone or stanozolol. Very good results are obtained by combination with testosterone propionate.

5) The combination of oral turinabol + oxandrolone is too weak, it can be recommended only for women.

6) You can use oral and injectable turinabol during mass-gaining cycle in various combinations, for example with testosterone, nandrolone or a combination thereof, instead of methandrostenolone (dianabol). It is recommended for those athletes who want to get quality muscles.

PCT is needed after most of these courses

Detekteringstider

There is a big controversy on this matter. There are some sources, which tells that turinabol depot is detectable up to 18 months and oral turinabol is detectable up to 12 months in worst-case  scenario. Some other people on the forums tell that 6-8 weeks in more than enough. However, we cannot understand where they all took such huge and unreliable numbers from. Doping tests rarely shows chlordehydromethyl-testosterone indeed and it was widely used in 60es and 70es so there is a good evidence that real detection times are much shorter. Most likely this mistake happened because athletes used some long-living substances like deca long with it. Or, maybe, these sources misrepresent turinabol with the same deca, we have seen some product descriptions, supposedly made for turanabol but after reading we understood they were just copypasted from deca descriptions, stupid, isnt’ it? Also, just as brain-storming: YES, it quickly leaves the body and not detectable in the urine tests, but probably modern blood tests can detect it for longer time, especially when using injectable turinabol.

So, it’s difficult to be absolutely sure, but we stick to the idea that Oral turinabol moves out of the body within 5-8 days after the end of cycle (if this was turanabol standalone cycle up to 100-150 mg/ ED) and any urine doping test shows negative results. Ok, if the risks of testing is too high and you are too nervous about it, discontinue turanabol 2 weeks before the contest to feel certain. 2 months is most likely sufficient evenfor injectable turinabol and sophisticated blood tests.

Another positive thing is that nowadays doping tests do not include turinabol at all, because it is considered to be a drug, which came out of usage after decease of Eastern Germany. Unfortunately, with its growing popularity one day it may change back as it happened with genabolom (norboleton) during Olympic Games 2000.

Biverkningar och PCT (Post Cycle Therapy) med Turanabol

Side effects of this drug depends on dosages or personal characteristics of an athlete. Women usually experience virilization side effects from prolonged use of the drug at dosages of above 20 mg per day. For men side effects occur very rarely as the estrogenic activity of the drug is quite low. Six weeks cycle makes no negative effects at all, nut normally one can use it even longer.

When doing 20 mg daily, endogenous testosterone production starts being suppressed  after ten days. However, it goes down only to 60-70% (for instance dianabol suppresses it to 30-40%), which is the reason of quick rejuvenation afterwards. Just 5 days after the cycle is over, natural testosterone production normalizes. 7 days after the cycle, endogenous testosterone production may even become higher (!!!) than before the cycle.

High dosages of oral turanabol version may lead to increasing of liver values, thus some protection like Liv-52 is needed. However, this is not a case when using injectable turanabol.

Other side effects such as gynecomastia, water retention, high blood pressure, acne, gastrointestinal pain, and uncontrolled aggressive behavior are highly unlikely.

Increased libido during cycle occurs for both sexes.

PCT is not absolutely necessary if used standalone but desirable if used more than 20 mg daily. In this instance clomid (clomiphen) is preferred to nolvadex (tamoxifen citrate). Do 3 tabs (150 mg) of clomiphen for the 1st day after the cycle, and 2 tabs / ED for two more weeks (you may reduce to 1 tab/ED at the end of PCT)

Kvinnlig användning

Oral Turinabol is relatively safe drug for women in dosages no more than 20 mg daily and if used for no longer than 4-5 weeks. According to many studies under such conditions it does not cause virilization effects.

Combination of oral turinabol + oxandrolone well suits for females.

Du kan Purchase online cheap Turinabol här.

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Winstrol Depot (StanoJect, Stanozolol, Stanabol, Stromba, StrombaJect)

Winstrol (winstrol depot, oral winstrol) is a brand name of very popular anabolic steroid called stanozolol, which is  a derivative of DHT (dihydrotestosterone). It has low androgenic ratio and thus low possibility of aromatization and estrogen-related side effects.

It’s primarily usage in bodybuilding is cutting (relief) cycles. However, winstrol is widely used not only by bodybuilders but also by non-bodybuilding athletes such as runners, cyclists, football players, soccer or hockey players and fighters of all kinds (kick-boxers for instance); i.e. in the sports where you have to be swift but not too heavy, because it provides you with lean mass and improves your strength without gaining excessive muscles.

Stanozolol is, one of the chemicals, which allowed amazing results to famous runner and simply exceptional athlete Ben Johnson. This substance provided him with a noticeable gain in muscle mass and relief, which could be perfect even for professional bodybuilder.

So, winstrol is a very effective steroid when used properly. It is important to distinguish between two forms of winstrol-stanozolol,  first is long-acting injectable version called winstrol-depot. Second is short-acting oral one (winstrol oral). Winstrol depot is more effective and thus preferred by most athletes.

The main usage of Winstrol (Winstrol Depot) in bodybuilding is preparation for a competition. When complemented by a proper calorie-rich and protein-rich diet,  Winstrol Depot provides the muscles with firmness and elasticity. Unfortunately, due to its low androgenic component, it is unable to protect the athlete from damages to muscle tissue. The absence of androgenic effect is compensated by stacking with Parabolan. The combination of injectable Winstrol 50 mg per day and Parabolan  2-3 amps / week is “a combination of top championships”.

Winstrol is good not only for preparation for a competition, but also in the bulking phase. Due to low water retention rapid weight gains with Winstrol are unlikely to occur. It provides rather moderate amount of lean and dry mass, which preserves after the cycle is over.

Injections of Winstrol in certain muscle groups are gaining in popularity because athletes have noticed that this leads to an accelerated growth of the affected muscles.

 

Dosering och användning

Injectable version is just slightly more efficient than the oral one and it’s not being destroyed by the liver. Because of this oral Winstrol requires a little bit higher dosages, however, most of athletes underdose it due to gastroenterial pain and increased liver values – oral winstrol is liver-toxic. So, here is where the myth of superiority of injectable winstrol comes from. People simply can’t take equal dosages of oral version. Common  dosage of oral stanozolol is  15-30 mg / ED, daily dosage should be split on two parts – in the morning and evening during a meal, drink a liquid along with it.

Feature of the injectable Winstrol Depot is that its substance is dissolved in the water and not oil unlike most of other steroids. Therefore, intervals between injections with Winstrol Depot must be shorter comparing to other oil-based steroids like Primobolan, Deca-Duraboline, Sustanon, Parabolan, etc. because its lifetime is much shorter. Practice has shown that Winstrol Depot should be administered at least twice a day and the best results are observed at a daily dose of 50mg. (300-350 mg/week). Milder dosage is 50 mg/EOD (150 mg/week)

Inject deep in muscles and constantly rotate the spots. However, if athlete wants to promote particular muscle group injections should be done into it.

 

Stapling

Winstrol (stanozolol) is all-purpose steroid, however, we should admit that in first turn it’s a cutting agent for bodybuilder and it plays rather limited role in bulking cycles. The main reason for using it in non-cutting cycles is that in limited dose it can lower SHBG, which, in turn, increases the amount of free testosterone in the body

Depending on the level of the athlete, one usually takes 50 mg of long-acting Winstrol /ED or EOD and Parabolan 76 mg/ every 1 – 3 days. Although there is no scientific evidence in favor of special interaction between Winstrol Depot and Parabolan, it’s very likely that a synergistic effect appears basing on real-world evidence. Other steroids that well stack with winstrol during pre-competition (cutting) cycle are Masterolone, Boldenone, Halotestin, Oxandrolone (anavar), Testosterone propionate, Primobolan and human growth hormone (HGH).

Bodybuilders who want to build up strength and mass often combine Winstrol injectable with Dianabol, Anadrol 50 (Anapolon, Oxymetholone), Testosterone,(long-acting) and Deca-Durabolin. With the combination of Anadrol 50 100 mg  / ED, 50 mg Winstrol depot 50 mg / ED and 400 mg of Deca / week athlete is slowly coming to the ambitious results.

Aged athletes and steroid novices can achieve good progress with Winstrol depot and Deca-Durabolin or Winstrol depot and Primobolan

 

Cycle 0

winstrol depot 50 mg / ED is a cutting stack. Some people may do 50 mg/Ed, it’s more aggressive.

 

Cycle  1:

Winstrol 100-150 mf/week + primobolan 200-300 mg/week for 6 weeks as a cutting phase AFTER regular deca-dianabol cycle

 

Cycle 2

Oxandrolone (anavar) 20-30 mg/ED + winstrol 150 mg/week + clenbuterol 120 mg/ED for 12 weeks; prabolan 152-228 mg / week for the first 8 weeks; proviron 300 mg/week + cytomel increase from 25 to 100 mg / week during weeks 9-12

 

Cycle 3

Winstrol 150 mg/w + parabolan 152 mg/w

 

Cycle 4

winstrol (150 mg/w) + dianabol (20-30 mg/ED) + test propionate (150 mg/w) for 8-10 weeks+clen at the end

 

Cycle 5

winstrol 50-100 mg/w + deca 300-200 mg/w

 

Cycle 6

winstrol oral 40-60mg/ED + equipoise (boldabol) 100-200 mg/w

 

Cycle 7

winstrol + trenbolone + clenbuterol – relief cycle for novices.

 

Cycle 8

primobolan 200-300 mg/w + winstrol 150-300 mg/w + oxandrolone 20-60 mg/ED + clenbuterol + PCT (tamo and HCG) – relief for advanced users

 

Cycle 9

boldenone 300 mg/w + winstrol oral 40 mg / ED + nandrolone phenilpropionate 300 mg / w – relief for advanced users

 

Detekteringstider

Oral stanozolol – 3 weeks
Injectable stanozolol (winstrol depot) – 3 months

 

Side effects and PCT (Post Cycle Therapy) with winstrol / stanozolol

Only small number of athletes report water retention or  other negative effects. However, one should be aware that oral winstrol can be toxic to the liver in excessive dosages.

 

Other non-androgenic side effects, which might occur are: headaches, muscle spasms, in rare cases high blood pressure can occur. The possibility of liver damage in the form of injectable Winstrol is very small, but still in high doses may increase the liver values.

 

Because the Winstrol Depot is dissolved in the water, injection,  in common is more painful comparing to oil-based gear and have to be taken more frequently. This leads to another negative effect – scar tissue on the often injection spots, which cause athletes t inject not only  into buttocks but also to shoulders, legs or even calves. Athletes wishing to avoid this take Winstrol Depot twice a week for 2-3ml. This decreases effectiveness but decreases pain and prevents scar tissue appearance.

As with most of other steroids, winstrol suppresses natural hormonal levels although not to that extension as many others. Running testosterone in a cycle containing Winstrol helps to avoid possible sexual dysfunction.

After winstrol cycle is over it’s necessary to do PCT: First week: 40mg of tamoxifen or 100mg clomiphen / ED or combo of both. One-two more weeks:  20mg of tamoxifen or 50mg clomiphen or combo of both.

 

Kvinnlig användning

It’s one of the few substances, which could be used more or less safely by females in low dosages because it has more anabolic properties than androgenic ones. But occasionally winstrol can cause virilization, even this small androgenic component may, become noticeable for women with a dose of only 50 mg per week. And troubles are almost guaranteed for female athletes with a dosage of 100 mg / week. Despite Winstrol moves out quickly, it can cause undesired accumulation of androgens in the female body, which cause virilization effects such as deep voice, hair growth, hypersexuality, etc. (something similar happens to some of natural brunettes). However, ambitious female athletes still use it 50 mg / EOD disregarding all side effects.

Normally, female athlete can tolerate around 5-10mg of stanosolol per day, which perfectly fits for oral winstrol usage

 

Oral Winstrol

As it has been already mentioned, injectable version is more efficient than the oral one but this is mostly because oral winstrol is used in lower dosages than injectable one and athletes simply don’t receive enough substance. If you take 50 mg of oral winstrol a day, the results will be almost par with 50 mg of Winstrol depot, however, you may have problems with stomach and liver.

From the other hand, oral winstrol is a good gear for females, they can do just 5-10 mg/ED and thus negative effects described above will not occur. Furthermore, oral winstrol allows splitting daily dosage on two equal parts,

 

Winstrol fakes

Due to popularity of winstrol there are many fakes on the market. The first thing to mention is that British Dragon winstrol depot and stanozolol (oral winstrol)  is no longer manufactured since they got busted, It might be still in circulation till the end of 2011 but anything with manufacture date after 2008 is a fake.

 

Brief description of stanozolol:
Activity: 48 hours
Classification: Anabolic / Androgenic Steroid
Dose: Men 25-100 mg / day
Acne: Rare
Water Retention: Rare
High Blood Pressure: Rare
Hepatotoxicity: Yes, it is 17-Alpha alkalized
Aromatization: No, it is a derivative of DHT
DHT Conversion: No
Decrease HPTA function: Weak


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Inlägget gjort

Deca Durabolin [Nandrolone Decanoate] review

Deca-durabolin is Organon tradename for extremely popular and widely used bulking anabolic steroid, which contains substance called nandrolone decanoate. Another less known but still very efficient nandrolone ester is phenylpropionate (Durabolin). There are dozens of different brand names like Retabolin or Nandrolona-D, but we’ll call it “Deca” for short.

With proper diet and usage it reduces body fat, provides great strength and size gains and does not cause problems with the liver. At the same time it increases hematorcrit level and bone density, therefore having positive effect not only in sport but also in treating certain forms of cancer,  anemia and osteoporosis, which is very important for females during menopause.

Main advantage of deca-durabolin is good anabolic effect and increased protein synthesis in muscle cells, which leads to superb muscle growth. However, protein building effect will occur in the body only if sufficient amount of calories and proteins is supplied, otherwise good results cannot be obtained.

Since Nandrolon stores more water in the connective tissues, it can temporarily ease or even cure existing pain in joints. This process is called water retention, which is more considerable comparing to using of injectable testosterones and it also leads to bigger outlook. Therefore, athletes who complain about pain in the shoulders, elbows, knees, can safely train with the aid of Deca-Durabolin.

Dosage of 400 mg per week also helps to accelerate recovery due to moderate androgenic effect of deca.

Dosering och användning

Athletes use Deca-Durabolin for muscle buildup and during bulking part of preparation for a contest because Deca promotes protein synthesis although other side of coin is water retention in the body. The dosage for men lies between 200 – 600 mg per week, the most common option is 400 mg. Scientific studies have shown that the best results can be achieved with 4 mg per 1 kg (2 mg/pound) of body weight.

At a dosage below 200 mg per week, the anabolic effects is very weak. 200-600 mg – anabolic effects growth rapidly with dosage. If dosage exceeds 600 mg / week, anabolic effect is still no more than effect of 600 mg  but side effects start killing all positive ones, so this dosage is not advisable. 1000mg is not better than 600 mg.

Beginners should use 200 mg/week, max 400 mg/week.

Inject deca-duraboline (nandrolone decanoate) in equal dosages twice a week deep in muscles, preferably buttocks.

Stapling

Deca-Durabolin is an effective steroid, which not only gives the desired results, but also goes well with other steroids in order to achieve a more rapid effect.

For muscle-build purposes deca very well combines with Dianabol (methandienone) och Testosteron. The classic Deca / Dianabol combo is for fast and strong gaining of muscle mass. Most athletes usually take 15 – 40 mg Dianabol per day and 200 – 400 mg Deca per week. Even faster results can be achieved with 400 mg of Deca / week and 500 mg Sustanon 250 / week.

Enormous gain in strength and muscle size could be achieved with 400 mg Deca, 500 mg Sustanon 250 / week and 30 mg of Dianabol /  day.

Professional users can combine deca with anapolon (anadrol/oxydrol) instead of dianabol.

A good startup stack is deca (deca durabolin, nandrolone decanoate) 400 mg/week + dianabol (danabol, naposim, methandienone) 40-50 mg/day. Length of cycle is 8 weeks. Don’t forget about anti-estrogen from the week 3 and 1 week after the cycle – tamoxifen or clomid (1 tab ED). For this cycle we advice you also using LIV-52 for liver protection.

Using anti-estrogen for this cycle is important. Also, it restores natural test production. Using liv-52 is not absolutely necessary but makes this cycle completely safe.

For the whole 8 week cycle athlete needs: Deca: 3200mg, Dianabol” ~ 2240-2800 mg, Tamoxifen/Clomid: 50 tabs, Liv-52: 1 bottle.

Although Deca-Durabolin is not an optimal steroid when preparing for competition due to excessive water storage many athletes still achieve good results during this phase of preparation if they have suficient time to “dry” afterwards. Alternatively, athlete may switch from long-acting deca to faster-acting ester duraboline (nandrolon-phenilpropionate) and thus avoid extra water retention.

Classic preparatory stack for contest is following: Deca-Durabolin 400 mg/week, Winstrol 50 mg/day, Parabolan 228 mg/week (every ampule contains 76 mg of substance) , and  Anavar (Oxandrolone) 25-30 mg/day (10 mg tabs).

Injectable Nandrolone (Deca-Durabolin) has no negative effect on the liver even if used for years UNLESS OVERDOSED. It can even be used by persons with liver diseases.

Even deca/dianabol combo negative effect on the liver could be eliminated quickly after user discontinues dianabol part.

Relatively  safe stack is a combination of Deca Durabolin 400 mg/week with Andriol 280mg / day. Both of these products are liver-friendly. However, PCT is still necessary.

Detekteringstider

If doping tests are expected it is better to refrain from taking Deca Durabolin because its traces remain in the body for quite a long time.

In certain cases Nandrolone Decanoate (deca-duraboline) is detectable for up to 18 months (1 and 1/2 year) although this is an extreme occasion.

Biverkningar och PCT (Post Cycle Therapy) med deca

It’s not advisable to use nandrolon for the athletes below 21 y.o. and especially in prepubescent period because it might be very harmful for their health.

Due to relatively low androgenic ratio, aromatization (i.e. conversion into estrogen) with Deca used standalone appears only at a dose of 400 mg per week, although this does not mean that one should neglect it completely. Aromatization appears for all steroids with androgenic component and may result in growing breast (so-called “bitch tits”), female-patter fat deposits, etc., so it’s much better to avoid such side effects by using anti-estrogen (see below).

Androgen-related side effects are unlikely to appear at dosages up to 400 mg but still should be considered. They include high blood pressure, blood clotting, which leads to frequent bleeding from the nose and a long healing of scratches, as well as increased production of the sebaceous gland and occasional acne. Some athletes also report headaches and sexual overstimulation. When very high doses are used over a prolonged period they can inhibit spermatogenesis. I.e., testes produce less testosterone because Deca-Durabolin, like almost all steroids, inhibits the release of gonadotropins from the hypophysis. To prevent this using of clomiphen/tamoxifen AFTER the cycle is must-do requirement.

Another common side effect is excessive water retention, which is not that bad in certain occasions, for instance pain in joints, but most athletes still want to avoid it.

Aromatization and partially water retention could be eliminated by use of proviron and tamoxifen (zymoplex, novadex, cytotam) or clomiphen. Take 1 tab of clomiphen/tamoxifen during the cycle, 3 tabs for the first day after it  and 2 tabs / ED (every day) for two-three weeks afterwards. Proviron should be added in case of “heavy” cycle when action of tamo/clom is not sufficient.

Kvinnlig användning

One of classic female stacks is Deca + Primobolan + winstrol depot or it’s variances Deca+oral primo / Deca+oral winstrol

Deca dosage up to 100 mg per week is normally quite safe for women. With higher dosages androgen-related side effects may occur. This is called virilization – irreversible appearing of deep “men’s” voice, increased growth of body hair, acne, increased libido, clitorishypertrophy.

To avoid skin problems female athletes may use more fast-acting duraboline (nandrolon-phenilpropionate). 50-100 mg of Duraboline per week could be a good choice for them who are very sensetive to androgenic side effects.

But in most cases even long-acting Deca 50-100 mg/week is OK and female athletes may combine it with Anavar 10 mg/ ED (every day). Both compounds, when taken in a low dosage, have only slight androgenic component so that virilization side effects only rarely occur. Deca provides substantial muscle growth and Anavar provides measurable strength gain with very low water retention. Switching from deca to primobolan in this stack will make cycle even safer but gains will be lower, too.

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